Methylisothiazolinone contact allergy – a growing epidemic

Lundov, Michael D.; Opstrup, Morten Schjørring; Johansen, Jeanne Duus

doi:10.1111/cod.12149

Cited by 102 publications

(113 citation statements)

References 17 publications

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“…More recently, there have been adverse health effects resulting from the use of cosmetics containing hydrolyzed wheat protein (Chinuki et al, 2011) and rhododenol (Nishigori et al, 2015;Tokura et al, 2015). In Europe as well, allergies to methylisothiazolinone are so widespread as to be described as an "epidemic" (Lundov et al, 2013). Therefore, safety assessment of cosmetics is becoming an increasingly important issue on a global level.…”

Section: Introductionmentioning

confidence: 99%

Actual consumption amount of personal care products reflecting Japanese cosmetic habits

et al. 2017

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-Safety assessments of cosmetics are carried out by identifying possible harmful effects of substances in cosmetic products and assessing the exposure to products containing these substances. The present study provided data on the amounts of cosmetic products consumed in Japan to enhance and complement the existing data from Europe and the United States, i.e., the West. The outcomes of this study increase the accuracy of exposure assessments and enable more sophisticated risk assessment as a part of the safety assessment of cosmetic products. Actual amounts of products applied were calculated by determining the difference in the weight of products before and after use by approximately 300 subjects. The results of the study of skincare products revealed that in comparison with the West, large amounts of lotions and emulsions were applied, whereas lower amounts of cream and essence were applied in Japan. In the study of sunscreen products, actual measured values during outdoor leisure use were obtained, and these were lower than the values from the West. The study of the use of facial mask packs yielded data on typical Japanese sheet-type impregnated masks and revealed that high amounts were applied. Furthermore, data were obtained on cleansing foams, makeup removers and makeup products. The data from the present study enhance and complement existing information and will facilitate more sophisticated risk assessments. The present results should be extremely useful in safety assessments of newly developed cosmetic products and to regulatory authorities in Japan and around the world.

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Section: Introductionmentioning

confidence: 99%

Actual consumption amount of personal care products reflecting Japanese cosmetic habits

et al. 2017

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“…Accordingly, isothiazolinones have gained notoriety in the last years as an emerging contact allergen [41][42][43][44] , present in wet wipes, skin cleansers, liquid soaps, lotions, shampoos and conditioners. 1,42,43,[45][46][47][48][49] Together with rubber chemical accelerators, MI and or MCI/MI are associated with at least doubled risk of occupational ACD.…”

Section: Discussionmentioning

confidence: 99%

Dermatite de Contacto Alérgica em Profissionais de Saúde

Pinheiro

Pestana

Marques

et al. 2017

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RESUMO -Introdução: A dermatite de contacto alérgica (DCA) constitui patologia profissional particularmente frequente em profissionais de saúde. Os alergénios responsáveis podem variar ao longe do tempo, com a exposição ocupacional e com o tipo de trabalho. Objectivos e Métodos: Com o objetivo de avaliar a realidade local, foi feita uma análise retrospetiva dos profissionais de saúde que realizaram testes epicutâneos no Serviço de Dermatologia do Centro Hospitalar e Universitário de Coimbra (CHUC), num período de 6 anos (2010)(2011)(2012)(2013)(2014)(2015), por suspeita de dermatite de contacto alérgica. Os doentes foram todos testados com uma Série Básica e com séries complementares orientadas pela história clínica. Resultados: Dos 1858 doentes testados, 125 (6,7%) eram profissionais de saúde, 114 de género feminino/11 masculino, idade média de 39,26±12,5 anos, maioritariamente enfermeiras (56), assistentes técnicos (48) e médicos (21), 71 com dermatite das mãos (56.8%), 22 com dermatite atópica e/ou outros sinais de atopia (17,6%). Noventa (72%) revelaram pelo menos um patch test (PT) positivo, 47 dos quais (52,2%) com relevância profissional. Doentes com dermatite das mãos tiveram mais frequentemente PT positivo (76,1%). Os metais causaram maior número de PT positivos (total 51; Ni-41, maioritariamente com relevância passada, Co-8; Cr-2), seguidos das fragrâncias (total 30; mistura de fragrâncias (FM)-I-10; Myroxylon pereirae-8; lyral-5; FM-II-4; citronellol-3), conservantes (total 29, dos quais 20 à metilisotiazolinona (MI) e/ou clorometilisotiazolinona/MI (MCI/MI)), borrachas (24; P-fenilenodiamina (PPD)/Isopropil-PPD-9) e medicamentos tópicos (total 14; iodopovidona 5). As principais causas da DCA profissional foram os desinfetantes/sabonetes líquidos e produtos de higiene dos doentes (15), borracha das luvas/calçado (12) e medicamentos sistémicos ou tópicos (8 antissépticos e 3 antibióticos parentéricos). Os principais alergénios com relevância profissional foram a MI e/ou MCI/MI (15), lanolina (9), formaldeído e/ou libertadores (7), iodopovidona (5), carbamatos (4), FM-I (3), cefalosporinas (3) e acrilatos (3 dentistas e/ou assistentes dentários). Em 37 dos 42 casos avaliados, houve uma melhoria franca ou resolução da DCA, após evicção do alergénio causal, nomeadamente o conservante MCI/ MI contido num sabonete líquido sob a designação de "Acticide ® MV". Conclusões: A dermatite das mãos, a principal apresentação da DCA em profissionais de saúde, não mostrou relação com atopia e foi mais frequentemente associada a PT positivos. PT positivos a isotiazolinonas e libertadores de formaldeído foram mais frequentes entre profissionais de saúde do que na população geral estudada, muito provavelmente devido à exposição cumulativa, pessoal e profissional, a estes conservantes em sabonetes líquidos de uso pessoal e hospitalar. O PT foi crucial para orientar individualmente os doentes e para alertar a comunidade hospitalar para a presença de alergénios no local de trabalho e estabelecer medidas preventivas mais ade...

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“…In recent years, cosmetic products have created a worldwide epidemic of contact-allergic reactions due to the presence of methylisothiazolinone (MI), in particular, both in leave-on and also rinse-off products [11,12]. MI is not only a weaker sensitizer than the chlorinated derivative methylchloroisothiazolinone (MCI) but also less efficient as a preservative; hence, larger use concentrations (up to 100 ppm) than the mixture MCI/MI (max.…”

Section: -Preservativesmentioning

confidence: 99%