Methylhistamine and Histamine in the Urine of Women During the Elaboration of Œstrogen

Green, Jack Peter; Fram, David H.; Kase, Nathan

doi:10.1038/2041165a0

Cited by 23 publications

(7 citation statements)

References 20 publications

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“…If these values are converted to pmol/mg creatinine, with the assumption that the average daily excretion of creatinine by normal adults is about 1.5 g [38], then the mean value obtained in the present study, about 1 nmol/mg creatinine, is similar to that reported earlier [25,26,[28][29][30][31][32].…”

Section: Discussionsupporting

confidence: 80%

“…The corresponding HA value in these same subjects was also within the range previously reported [25,26,[28][29][30][31][32]39]. The female with an unusually high concentration of urinary histamine (subject 3, Table 4) was on chronic medication but the type of drug was not disclosed.…”

Section: Discussionsupporting

confidence: 61%

“…Early work showing high HA excretion by a woman taking a preparation containing estradiol and progesterone was similarly not accompanied by high t-MH excretion [26]. In another patient, treatment with human pituitary follicle-stimulating hormone resulted in increased excretion of t-MH with no concomitant increase in HA [25]. Thus, the levels of these two amines in urine may vary independently, as also indicated in Table 4.…”

Section: Discussionmentioning

confidence: 79%

“…1.8) [10] to form tele-methylhistamine (t-MH; i.e., 1-methyl-4-(flaminoethyl)imidazole; for nomenclature, see [11 ]. Since HA is metabolized exclusively to t-MH by brain, and, since no uptake mechanism for HA could be shown in brain [12][13][14][15], t-MH levels in brain or cerebrospinal fluid (CSF) may reflect histaminergic activity, t-MH has been measured in the brain of guinea pig [16,17], cat [18,19], cow [20], mouse [21] and rat [22][23][24], in urine [25][26][27][28][29][30][31][32], plasma [32], and very recently, in CSF [33].…”

Section: Introductionmentioning

confidence: 99%

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Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine, and plasma

et al. 1982

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A gas chromatographic-mass spectrometric method described by us to measure tele-methylhistamine (t-MH) in brain was used to measure t-MH in human cerebrospinal fluid (CSF), urine and plasma. The presence of t-MH in these body fluids was rigorously established. No pros-methyl-histamine could be detected, and it was used as internal standard to quantify t-MH in the fluids. The mean levels of t-MH were: urine, 943 pmol/mg creatinine; plasma, 12.3 pmol/ml; and CSF, 2.2 pmol/ml. Parallel measurements of histamine by a radioenzymatic method showed, respectively, 182 pmol/mg creatinine; 19.5 pmol/ml; and 388 pmol/ml. The levels of HA in CSF, much higher than those of its metabolite, t-MH, are high enough to stimulate HA receptors in the central nervous system.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

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Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine, and plasma

et al. 1982

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“…Estrogens have been shown to modulate histamine receptors at the hypothalamic level (9). The female sex hormones, particularly estrogens, are suspected of altering histamine metabolism (5,7). Cardiac histamine receptors may have important functions in cardiovascular physiology (6).…”

Section: Introductionmentioning

confidence: 99%

Modulation by estradiol of rabbit atrial chronotropic response to histamine

Baksi

Hughes

1983

Basic Res Cardiol

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The chronotropic response (delta rate) to histamine of atria from estradiol 17-beta (E2; 0.1 mg/kg)-treated (14 days) rabbit was significantly greater compared to those from control rabbits. However, the maximum response of atria from rabbits treated with a higher dose of E2 (1.0 mg/kg) was not significantly different from control. Cimetidine (2.8 X 10(-7) M) inhibited the theoretical maximum income in rate to histamine in all 3 groups, control 25%, E2 (0.1 mg) 42% and E2 (1.0 mg) 35%.

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