Methylglyoxal induces peritoneal thickening by mesenchymal-like mesothelial cells in rats

Abstract

MGO induced peritoneal fibrous thickening with the proliferation of mesenchymal-like mesothelial cells in vivo. These cells may be transdifferentiated from mesothelial cells by EMT via Snail and play an important role in peritoneal fibrous thickening.

PPAR-γ agonist rosiglitazone protects peritoneal membrane from dialysis fluid-induced damage

“…46,47 Mesothelial cells also express RAGE 48 and AGEs stimulate the production of matrix components by these cells as well as the synthesis of cytokines and growth factors, such as TGF-b and VEGF. 9, [49][50][51][52] AGEs may also induce MMT in vitro and in vivo, 46,50,51 and they can reduce cell proliferation and induce mesothelial cells apoptosis. 53 Here, we demonstrate that RSG-treatment decreases the peritoneal accumulation of AGEs in PD fluidinstilled mice.…”

Nano-sized carriers in gene therapy for peritoneal fibrosisin vivo

“…Repeated exposure to peritoneal dialysis solutions containing high concentrations of glucose is considered to play a central role in the development of peritoneal fibrosis in patients undergoing peritoneal dialysis [3–6]. Glucose is degraded to glucose-degradation products including methylglyoxal, glyoxal, formaldehyde, and 3-deoxyglucosone during heat sterilization [14–16], and these products are further transformed to advanced glycation end-products [14,15,17–19]. Both the glucose-degradation products and advanced glycation end-products have been reported to activate transforming growth factor (TGF)-β 1 signaling in the peritoneal membrane, thus promoting peritoneal fibrosis [14,15,17–20].…”

“…Glucose is degraded to glucose-degradation products including methylglyoxal, glyoxal, formaldehyde, and 3-deoxyglucosone during heat sterilization [14–16], and these products are further transformed to advanced glycation end-products [14,15,17–19]. Both the glucose-degradation products and advanced glycation end-products have been reported to activate transforming growth factor (TGF)-β 1 signaling in the peritoneal membrane, thus promoting peritoneal fibrosis [14,15,17–20]. Activated TGF-β 1 promotes the proliferation of fibroblasts from different origins, including mesothelial cells via mesothelial–mesenchymal transition, bone marrow-derived cells, and endothelial cells, in addition to resident fibroblasts [21–24].…”

Matrix Metalloproteinases Cause Peritoneal Injury in Peritoneal Dialysis

“…GDPs are generated in PD solutions during heat sterilization and storage, and contribute to the bioincompatibility of conventional PD www.intechopen.com solutions. MMP-2 levels in the peritoneal effluent increased in models of peritoneal injury induced by methylglyoxal (MGO) or formaldehyde, both extremely toxic GDPs [12,13]. In models of peritoneal injury induced by chlorhexidine gluconate and MGO, abdominal cocoons were often formed, while in models induced by talc and formaldehyde, adhesions of the peritoneum were observed [7-9, 11, 12].…”