Methylglyoxal and Its Role in Obesity-Associated Heart Failure with Preserved Ejection Fraction

Abstract

Heart failure (HF), including early-onset HF with preserved ejection fraction (HFpEF) is a common cause of morbidity and frequent hospitalizations in obese individuals. Diagnosis of HFpEF remains challenging due to its heterogeneous phenotype. To date, the molecular causes for the early-onset decrease in myocardial energetics, increase in global longitudinal strain, dysregulation of the endothelial cells in the coronary vasculature, myocardial fibrosis and inflammation