Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Type 2 Diabetes Mellitus

Zhong, Jian‐Hong; Rodríguez, A. Chapin; Yang, Nianhong; Li, Le‐Qun

doi:10.1371/journal.pone.0074521

Cited by 29 publications

(30 citation statements)

References 56 publications

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“…However, the results were not consistent [13]–[19]. A systematic review on Arab ethnicity found that MTHFR C677T polymorphism was significantly associated with T2DM [14], but another systematic review found that there was no association between MTHFR C677T polymorphism and T2DM around the world, similar results were repeated for ethnic group (Asian, Caucasian, African) [13].…”

Section: Introductionmentioning

confidence: 98%

Methylenetetrahydrofolate Reductase C677T Polymorphism and Type 2 Diabetes Mellitus in Chinese Population: A Meta-Analysis of 29 Case-Control Studies

Zhu

Zhi

et al. 2014

PLoS ONE

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BackgroundMethylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, had significant effects on the homocysteine levels. The common functional MTHFR C677T polymorphism had been extensively researched. Several studies had evaluated the relationship between MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM), but the results were still controversial in the Chinese Han population. This meta-analysis was conducted to evaluate the relationship between MTHFR C677T polymorphism and T2DM in the Chinese Han population.MethodsWe searched the relevant studies in multiple electronic databases, which published up to December 2013. We reviewed and extracted data from all the included studies on the relationship between MTHFR C677T polymorphism and T2DM in the Chinese Han population. The odds ratios (ORs) and their 95% confidence intervals (95%CIs) were used to evaluate the relationship. Fixed-effects and random-effects meta-analysis were used to pool ORs by the heterogeneity. Publication bias and sensitivity analysis were also examined.Results29 studies were finally included in our meta-analysis, which contained 4656 individuals with T2DM and 2127 healthy controls. There was a significant relationship between MTHFR C677T polymorphism and T2DM under dominant (OR: 1.70, 95% CI: 1.42–2.02), recessive (OR: 1.48, 95% CI: 1.21–1.80), homozygous (OR: 1.89, 95% CI: 1.47–2.42), heterozygous (OR: 1.58, 95% CI: 1.33–1.87), and additive (OR: 1.46, 95% CI: 1.28–1.68) genetic model in a random-effects model. Subgroup analysis also reached similar results. Sensitivity analysis indicated that the overall result were dependable.ConclusionsThere was a significant relationship between MTHFR C677T polymorphism and T2DM in the Chinese Han population. The results of our meta-analysis suggested that MTHFR 677T allele might be a risk genetic factor of T2DM in the Chinese Han population.

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Section: Introductionmentioning

confidence: 98%

Methylenetetrahydrofolate Reductase C677T Polymorphism and Type 2 Diabetes Mellitus in Chinese Population: A Meta-Analysis of 29 Case-Control Studies

Zhu

Zhi

et al. 2014

PLoS ONE

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“…Due to the divergent results among single‐country studies, several systematic meta‐analyses have been undertaken to determine conclusively whether MTHFR C677T is associated with the risk of T2DM. In 2013, Chinese academics Zhong, Rodriguez, Yang, and Li () conducted a meta‐analysis regarding MTHFR C677T and T2DM. Their meta‐analysis included 4,855 T2DM patients and 5,242 controls.…”

Section: Discussionmentioning

confidence: 99%

Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility

Meng

Liu

Ma³

et al. 2019

Molec Gen & Gen Med

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IntroductionMethylenetetrahydrofolate reductase (MTHFR) is essential in mediating folate metabolism, and thus plays an important role in diabetes and diabetic complications. MTHFR C677T (rs1801133 C>T) polymorphism has been proposed to be linked with type 2 diabetes mellitus (T2DM) susceptibility. However, the conclusions are inconsistent. Therefore, we rechecked their linkage aiming to obtain a more reliable estimation by performing an updated meta‐analysis.MethodsWe searched electronic databases PubMed, EMBASE, CNKI, and Wanfang to obtain studies updated to October 2019.ResultsAfter carefully screening, we finally incorporated 68 studies with 10,812 cases and 8,745 controls. The genotype frequency of C677T polymorphism was analyzed pooled to generate odds ratios (ORs) and 95% confidence intervals (CIs). Pooled results presented that MTHFR C677T polymorphism was significantly associated with T2DM under homozygous (OR = 1.64, 95% CI = 1.39–1.94), heterozygous (OR = 1.38, 95% CI = 1.20–1.59), recessive (OR = 1.41, 95% CI = 1.23–1.61), dominant (OR = 1.47, 95% CI = 1.27–1.70), and allele (OR = 1.37, 95% CI = 1.23–1.52) genetic models. Stratified analysis demonstrated that C677T genotype was associated with T2DM in Asian populations, but not Caucasian and African populations.ConclusionOur results indicated that MTHFR C677T polymorphism confers to T2DM, especially in Asian populations. Much more large‐scale case–control studies are needed to strengthen such conclusion in the future.

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“…A significant association of Ala allele with retinopathy in Caucasians was observed; however, o significant results were observed in association with T2DM and the other related complications. No association of the C677T polymorphism of MTHFR gene was found in Africans, Asians, and Caucasians (48). MTHFR is a gene that is involved in DNA methylation and synthesis along with the regulation of folate activity.…”

Section: Genetics Of Type 2 Diabetes In South Asian Populationmentioning

confidence: 99%

Genetics of Type 2 Diabetes Mellitus-Asian Perspective (A Review)

Fawwad¹,

Rashid²,

Basit³

2017

Turk J Endocrinol Metab

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Type 2 diabetes mellitus (T2DM) is a metabolic disorder that has come up as a major cause of mortality and continues to cause enormous socio-economic loss across the globe. In the purview of this, a thorough understanding of the pathophysiology, etiology, and pathogenesis of the condition is the need-of-the-hour so as to develop potent therapeutics to have a better control of T2DM. In the developing countries, especially the South Asian region, the condition has become a major health issue owing to the low income and distinct socio-economic patterns. In the European population, a variety of genes have been found to be associated with T2DM; however, their contribution to the other ethnic groups is still unclear. In recent years, various research groups analyzed the prevalence of such genes in Asian populations. The Genome Wide Association Scan (GWAS) successfully identied more than 70 genetic variants that are associated with the T2DM. The present article intends to provide a comprehensive account of the major studies on the genetics of T2DM, with special reference to the Asian population. The various risk factors and the complications associated with the T2DM will be discussed. The review also highlights the major differences and similarities between the susceptibility loci that have been investigated in different ethnicities to provide a novel insight into the disease pathogenesis and its heritability patterns. The information presented, herein, on the genetics of type 2 Diabetes Mellitus holds signicance as it paves the way for the development of potential biomarkers and strengthens the fact that specic genetic alterations have important functional roles in the progression or development of T2DM. Keywords: Diabetes; genetics; genome-wide association scan Tip 2 diabetes mellitus (T2DM), dünya genelinde mortalitenin majör nedeni olan bir metabolik bozukluktur. Hastalığın patozyolojisini, etiyolojisini ve patogenezini daha iyi anlamak için, uygun şekilde odaklanmış terapötik ve araştırma çabaları gereklidir; çünkü hastalığın prevalansı dünya genelinde yaşamları ve ekonomileri etkilemektedir. Gelişmekte olan ülkelerde özellikle Güney Asya bölgesinde, düşük gelir ve farklı sosyoekonomik paternlere bağlı olarak merkezi bir sağlık yükü olmaya başlamaktadır. Avrupalılar arasında gen çeşitliliği T2DM ile ilişkilidir, fakat bu genetik varyantların diğer etnik gruplardaki katkıları hâlâ açık değildir. Asyalılarda yapılan çeşitli yeni çalışmalar bu genlerin bazılarını çoğaltmıştır. "Genom Wide Association Scan (GWAS)", T2DM ile ilişkili 70'ten fazla genetik varyantı başarılı bir şekilde tanımlamıştır. Metodoloji, özellikle Asya ülkelerinde T2DM'nin genetiğiyle ilişkili literatür araştırmasını içermiştir. Bu gözden geçirme T2DM, risk faktörleri ve komplikasyonlarıyla ilişkili majör genetik tabanlı çalışmaların kısa bir özetidir. Ayrıca, farklı etnisitelerde araştırılan duyarlılık loküsünun majör faklılıklarını ve benzerliklerini vurgulamaktadır ki bu da patogenez ve kalıtım mekanizmalarına yeni bir bakış açısı sağ-lama...

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Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Type 2 Diabetes Mellitus

Cited by 29 publications

References 56 publications

Methylenetetrahydrofolate Reductase C677T Polymorphism and Type 2 Diabetes Mellitus in Chinese Population: A Meta-Analysis of 29 Case-Control Studies

Methylenetetrahydrofolate Reductase C677T Polymorphism and Type 2 Diabetes Mellitus in Chinese Population: A Meta-Analysis of 29 Case-Control Studies

Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility

Genetics of Type 2 Diabetes Mellitus-Asian Perspective (A Review)

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