Abstract:Chitosan/DNA blend hydrogel (CDB) and chitosan/pectin blend hydrogel (CPB) were synthesized using an emulsion (oil-in-water) technique for the release of methylene blue (model molecule). Both hydrogels were characterized by swelling assays, Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM), before and after the methylene blue (MB) loading. Higher swelling degrees were determined for both hydrogels in simulated gastric fluid. FT-IR spectra i… Show more
“…Thereafter, swelling continued increasing more slowly up to 1830% at day 7. Since pectin moieties were negatively charged with -COO- groups at pH 7.4, electrostatic repulsions were promoted and, thus, the swelling ability increased [ 55 , 56 ]. In this context, having a high swelling capacity is desirable in order to absorb wound exudates that could slow the wound healing and macerate the nearby skin [ 57 ].…”
Chitosan-pectin hydrogels were prepared, and their rheological properties were assessed in order to select the best system to develop scaffolds by 3D printing. Hydrogels showed a weak gel behavior with shear thinning flow properties, caused by the physical interactions formed between both polysaccharides, as observed by FTIR analysis. Since systems with high concentration of pectin showed aggregations, the system composed of 2 wt% chitosan and 2 wt% pectin (CHI2PEC2) was selected for 3D printing. 3D printed scaffolds showed good shape accuracy, and SEM and XRD analyses revealed a homogeneous and amorphous structure. Moreover, scaffolds were stable and kept their shape and size after a cycle of compression sweeps. Their integrity was also maintained after immersion in PBS at 37 °C, showing a high swelling capacity, suitable for exudate absorption in wound healing applications.
“…Thereafter, swelling continued increasing more slowly up to 1830% at day 7. Since pectin moieties were negatively charged with -COO- groups at pH 7.4, electrostatic repulsions were promoted and, thus, the swelling ability increased [ 55 , 56 ]. In this context, having a high swelling capacity is desirable in order to absorb wound exudates that could slow the wound healing and macerate the nearby skin [ 57 ].…”
Chitosan-pectin hydrogels were prepared, and their rheological properties were assessed in order to select the best system to develop scaffolds by 3D printing. Hydrogels showed a weak gel behavior with shear thinning flow properties, caused by the physical interactions formed between both polysaccharides, as observed by FTIR analysis. Since systems with high concentration of pectin showed aggregations, the system composed of 2 wt% chitosan and 2 wt% pectin (CHI2PEC2) was selected for 3D printing. 3D printed scaffolds showed good shape accuracy, and SEM and XRD analyses revealed a homogeneous and amorphous structure. Moreover, scaffolds were stable and kept their shape and size after a cycle of compression sweeps. Their integrity was also maintained after immersion in PBS at 37 °C, showing a high swelling capacity, suitable for exudate absorption in wound healing applications.
“…By combining KCG with additional polymers through chemical crosslinking, a novel adsorbent with tremendous improved adsorption capabilities and enhanced properties might be developed. [46][47][48][49] For enhancing thermal stability, mechanical properties, and high adsorbent capacity, KCG was blended with natural polysaccharides like tamarind kernel powder (TKP) via chemical crosslinking. 50 TKP is a biodegradable and biocompatible galactoxyloglucan produced from Tamarindus indica kernels.…”
Section: Introductionmentioning
confidence: 99%
“…As a result, dealing with the improvement of physicochemical properties is a difficult issue in the formation of this bio‐adsorbent. By combining KCG with additional polymers through chemical crosslinking, a novel adsorbent with tremendous improved adsorption capabilities and enhanced properties might be developed 46–49 . For enhancing thermal stability, mechanical properties, and high adsorbent capacity, KCG was blended with natural polysaccharides like tamarind kernel powder (TKP) via chemical crosslinking 50 .…”
The objective of this study was to develop an eco‐friendly, cost‐effective, and efficient adsorbent using kappa‐carrageenan (KCG) and tamarind kernel powder (TKP) based cross‐linked 3‐D network hydrogel. The equilibrium swelling capacity of 1429% was achieved by optimization studies. The KCG/TKP hydrogel was characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, field emission scanning electron microscopy, energy dispersive spectroscopy, and thermogravimetric analysis. This hydrogel was employed for the efficient removal of brilliant green (BG) and rose bengal (RB) dye from wastewater. BG and RB were used as a cationic and anionic model dye, respectively. The adsorption capacity of model dyes on KCG/TKP was investigated under different parameters like dye concentration, pH, temperature, and adsorbent amount. With remarkable adsorption capacity, the hydrogel demonstrated a strong dependence on the pH of the medium. The kinetics, adsorption isotherm, thermodynamic studies, and reusability were investigated. The KCG/TKP hydrogel follows pseudo‐second‐order kinetics and the Langmuir isotherm model for the adsorption of both BG and RB model dyes. Spontaneity and exothermic behavior of the adsorption process were revealed by thermodynamic findings. At pH 9, the maximum adsorption capacity of BG was 840.33 mg g−1 while the maximum adsorption capacity of RB was 168.06 mg g−1 at pH 5.
“…32 It should be noted that while the absolute position of this particular absorption band depends on the environment and the binding state of MB, it is almost always observed with similar intensities in the wavenumber range from about 1600 to 1700 cm −1 and may thus serve as a MB-specific marker band also in the case of intercalative DNA binding. 32,35–38 The observed increases in the intensities of the MB-specific absorption bands at the positions of the adsorbed DNA origami can be explained by local variations in the surface density of MB molecules due to their specific binding to the DNA origami triangles. The MB-specific bands between 1000 and 1250 cm −1 and between 1600 and 1700 cm −1 can also be resolved in the IR reflection absorption spectrum of the same sample investigated in Fig.…”
The efficient loading of DNA nanostructures with intercalating or groove-binding drugs is an important prerequisite for various applications in drug delivery. However, unambiguous verification and quantification of successful drug loading...
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