Methylene Blue/Collagen Mixture for CT-Guided Presurgical Lung Nodule Marking: High Efficacy and Safety

Aoun, Hussein D.; Littrup, Peter J.; Heath, Katherine E.; Adam, B.; Prus, M.; Beydoun, Rafic; Baciewcz, Frank

doi:10.1016/j.jvir.2020.04.028

Cited by 13 publications

(14 citation statements)

References 26 publications

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“…The technical challenge of segmentectomy is to perform a true anatomical and oncologic resection with safe margins. A multimodality imaging approach [89,90] to segmentectomy, using a combination of colored or fluoroscopic endoscopic [91][92][93] or physical X-ray [94,95] markings and 3D reconstructions of segmental vessels and bronchus, segments and tumor [89,96,97], helps surgeons to identify small, non-visible, and non-palpable tumors, and to anticipate individual anatomy in the surgical space and expected oncologic margins to perform oncologically effective and safe personalized tailored segmentectomy (Figure 4). These imaging tools are helpful for open segmentectomy, and even more for minimally invasive approaches, using indocyanine green and near-infrared angiography [98][99][100] to identify the intersegment plan.…”

Section: "Resecting Less" Segmentectomy For Early-stage Nsclc From Present To Futurementioning

confidence: 99%

The Role of Surgery in Lung Cancer Treatment: Present Indications and Future Perspectives—State of the Art

Montagne

Guisier

Vénissac

et al. 2021

Cancers

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Non-small cell lung cancers (NSCLC) are different today, due to the increased use of screening programs and of innovative systemic therapies, leading to the diagnosis of earlier and pre-invasive tumors, and of more advanced and controlled metastatic tumors. Surgery for NSCLC remains the cornerstone treatment when it can be performed. The role of surgery and surgeons has also evolved because surgeons not only perform the initial curative lung cancer resection but they also accompany and follow-up patients from pre-operative rehabilitation, to treatment for recurrences. Surgery is personalized, according to cancer characteristics, including cancer extensions, from pre-invasive and local tumors to locally advanced, metastatic disease, or residual disease after medical treatment, anticipating recurrences, and patients’ characteristics. Surgical management is constantly evolving to offer the best oncologic resection adapted to each NSCLC stage. Today, NSCLC can be considered as a chronic disease and surgery is a valuable tool for the diagnosis and treatment of recurrences, and in palliative conditions to relieve dyspnea and improve patients’ comfort.

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Section: "Resecting Less" Segmentectomy For Early-stage Nsclc From Present To Futurementioning

confidence: 99%

The Role of Surgery in Lung Cancer Treatment: Present Indications and Future Perspectives—State of the Art

Montagne

Guisier

Vénissac

et al. 2021

Cancers

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“…The mean dosage of administered MB was 1.22 ml ranging from 0.04 to 7 ml. MB was administered in combination with autologous blood in two reports ( 19 , 28 ), as a medical glue in two reports ( 33 , 34 ), non-ionic contrast agent in two reports ( 15 , 17 ), collagen in one report ( 31 ), and in a mixture of MB, fibrinogen, and thrombin in one report ( 24 ). No MB-related side effects were demonstrated in the different studies.…”

Section: Resultsmentioning

confidence: 99%

“…In order to avoid MB diffusion or dilution, surgery should be scheduled preferably the same day of nodule MB labelling due to the decrease of color intensity and the higher risk of targeting failure following the first 24 h from the targeting procedure ( 17 , 32 ). Mixing MB with collagen or blood enhanced MB color intensity duration ( 19 , 28 , 31 ). ICG demonstrated similar results in terms of localization effectiveness.…”

Section: Resultsmentioning

confidence: 99%

Fluorescence-guided lung nodule identification during minimally invasive lung resections

et al. 2022

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In the last few years, minimally invasive surgery has become the standard routine practice to manage lung nodules. Particularly in the case of robotic thoracic surgery, the identification of the lung nodules that do not surface on the visceral pleura could be challenging. Therefore, together with the evolution of surgical instruments to provide the best option in terms of invasiveness, lung nodule localization techniques should be improved to achieve the best outcomes in terms of safety and sensibility. In this review, we aim to overview all principal techniques used to detect the lung nodules that do not present the visceral pleura retraction. We investigate the accuracy of fluorescence guided thoracic surgery in nodule detection and the differences among the most common tracers used.

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“…Imaging positioning methods include intraoperative ultrasonic positioning [19], near-infrared uorescence imaging positioning [20] and surgical navigation puncture robot system [21], but the requirements for equipment and the technical level of operators were high, which was di cult to be widely popularized. However, injection of liquid material-mediated localization method, including injection of lipiodol [22], methylene blue [23], medical glue [24], indocyanine green uorescent agent [25] and other liquids, had some shortcomings such as short retention time, easy diffusion and uncontrollable injection dose, and had not received more attention from thoracic surgeons.…”

Section: Comparison Of Vats Operation Indexes Between the Two Groupsmentioning

confidence: 99%

CT Guided Placement of the End of the Microcoil in the Pleural Cavity: A More Helpful Method for Video-Assisted Thoracic Surgery (VATS) Resection of Ground Glass Opacity (GGO)

Dong

et al. 2021

Preprint

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Objective To investigate and summarize the effectiveness and safety of CT guided microcoil localization before video-assisted thoracic surgery (VATS) for the removal of ground glass opacity (GGO).Method 147 patients with GGO who were treated in our hospital from January 2019 to February 2021 were retrospectively analyzed. They were divided into two groups according to the final position of the end of the microcoil, intracavity group (n=78) and extracavity group (n=69). Comparison of the two groups of patients with puncture complications, and the influence of the end position of the coil for VATS.Results The proportion of supine and prone position in the intracavity group was significantly higher than that in the extracavity group (82.1% vs. 66.7%, P<0.05). The incidence of intrapulmonary hemorrhage, chest pain and coil displacement in the intracavitary group was significantly lower than that in the extracavitary group (28.2% vs. 46.4%; 19.2% vs. 39.1%;1.3% vs. 11.6%, P<0.05), and the incidence of pneumothorax had no significant difference(P>0.05). The time of VATS and the rate of conversion to thoracotomy in the intracavity group were significantly lower than those in the extracavity group (103.4±21.0min vs. 112.2±17.3min, 0% vs. 5.8%, P<0.05).Conclusion CT-guided placement of the microcoil was a very practical, simple and convenient localization method before VATS with high success rate and few complications, further more, it was a better method to place the end of the coil in the pleural cavity because of the lower complication rate, shorter VATS time and lower rate of thoracotomy conversion.

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Methylene Blue/Collagen Mixture for CT-Guided Presurgical Lung Nodule Marking: High Efficacy and Safety

Cited by 13 publications

References 26 publications

The Role of Surgery in Lung Cancer Treatment: Present Indications and Future Perspectives—State of the Art

The Role of Surgery in Lung Cancer Treatment: Present Indications and Future Perspectives—State of the Art

Fluorescence-guided lung nodule identification during minimally invasive lung resections

CT Guided Placement of the End of the Microcoil in the Pleural Cavity: A More Helpful Method for Video-Assisted Thoracic Surgery (VATS) Resection of Ground Glass Opacity (GGO)

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