Methylene blue chromoendoscopy for Barrett's esophagus: Coming soon to your GI unit?

Canto, Marcia Irene

doi:10.1067/mge.2001.117958

Cited by 30 publications

(20 citation statements)

References 19 publications

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“…We found the sensitivity and specificity rates of methylene blue staining for detecting specialized columnar epithelium to be 87% and 71%, respectively. The discrepancies among the studies in the literature result from differences in methodology in terms of concentrations and amount of dye, N-acetyl cystein, water to wash out excess dye, waiting time after scattering of n-acetyl cystein and methylene blue, and the use of a washing catheter or syringe [33]. The mean cost of methylene blue staining is less than US$9, and the procedure requires approximately 8 min more time than conventional endoscopy.…”

Section: Discussionmentioning

confidence: 89%

The usefulness of chromoendoscopy with methylene blue in Barrett’s metaplasia and early esophageal carcinoma

et al. 2007

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Section: Discussionmentioning

confidence: 89%

The usefulness of chromoendoscopy with methylene blue in Barrett’s metaplasia and early esophageal carcinoma

et al. 2007

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“…Consistent with previous studies, we found that staining with MB revealed details of cell structure, including both nuclei and gland formation. The mechanism of staining with MB involves absorption of dye into surface cells, followed by staining of nuclei and cytoplasm …”

Section: Discussionmentioning

confidence: 99%

Double staining with crystal violet and methylene blue is appropriate for colonic endocytoscopy: An in vivo prospective pilot study

Ichimasa

Kudo

Mori

et al. 2013

Digestive Endoscopy

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Background and AimEndocytoscopy (EC) at ultra-high magnification enables in vivo visualization of cellular atypia of gastrointestinal mucosae. Clear images are essential for precise diagnosis by EC. The aim of the present study was to evaluate the optimal staining method for EC in the colon.MethodsThirty prospectively enrolled patients were allocated 1:1:1 to three distinct staining methods: 0.05% crystal violet (CV) alone, 1% methylene blue (MB) alone, or CV + MB (CM double). Normal rectal mucosae were stained with each dye and videos of EC images were recorded. Visibility of nuclei and gland formation after staining were evaluated as ‘recognizable’ or ‘not recognizable’. Time for each parameter to become ‘recognizable’ was measured, and the average times for the three staining regimens were compared.ResultsMB alone and CM double staining resulted in ‘recognizable’ (102 ± 27 vs 89 ± 22 s, P = 0.263) nuclei within comparable periods of time, whereas CV alone was unable to identify nuclei. Gland formation became ‘recognizable’ sooner after CM double staining than after MB alone (61 ± 16 vs 108 ± 24 s, P < 0.001).ConclusionsDouble staining with CV and MB, which rapidly provided recognizable images of both nuclei and gland formation, is an appropriate staining regimen for colonic EC.

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“…This is due to technical differences in staining procedures, differences in interpretation of staining results, methodological differences, differences in level of experience with chromoendoscopy, and confounding factors like inflammatory mucosal changes. Furthermore, differences in the a priori chance of finding an abnormality, such as detection of IM in a short or a long segment of columnar epithelium, may have led to contradictory results (4).…”

Section: Chromoendoscopy and Structural Enhancementmentioning

confidence: 99%

Value of magnification endoscopy in current clinical practice

Schwartz

2004

Scandinavian Journal of Gastroenterology

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Schwartz MP. Value of magnification endoscopy in current clinical practice. Scand J Gastroenterol 2004;39 Suppl 241:27-31. Ongoing technological developments in endoscopy have led to an ever improving evaluation and management of digestive diseases. The recent development of a new range of high-power magnification, or zoom, endoscopes has boosted interest in this technique, which has become increasingly available to the modern gastroenterologist. Magnification is often used in conjunction with chromoendoscopy in order to improve the detection and diagnosis of neoplastic tissue. Currently, the main clinical indications are the diagnosis of Barrett oesophagus, the colonoscopic surveillance of colonic polyps and the assessment of disease severity or the presence of dysplasia in inflammatory bowel disease. In this article we present an overview of the clinical implementations of magnification endoscopy in current and future gastroenterological practice.

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Methylene blue chromoendoscopy for Barrett's esophagus: Coming soon to your GI unit?

Cited by 30 publications

References 19 publications

The usefulness of chromoendoscopy with methylene blue in Barrett’s metaplasia and early esophageal carcinoma

The usefulness of chromoendoscopy with methylene blue in Barrett’s metaplasia and early esophageal carcinoma

Double staining with crystal violet and methylene blue is appropriate for colonic endocytoscopy: An in vivo prospective pilot study

Value of magnification endoscopy in current clinical practice

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