Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis

Kießlich, Ralf; Fritsch, Janine; Holtmann, Martin; Koehler, Heinz H.; Stolte, Manfred; Kanzler, Stephan; Nafe, B.; Jung, Michael; Galle, Peter R.; Neurath, Markus F.

doi:10.1053/gast.2003.50146

Cited by 797 publications

(591 citation statements)

References 25 publications

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“…Nine dysplastic lesions were diagnosed at chromoendoscopy, while no dysplasia was detected in random biopsies and no additional lesions were detected. Separate prospective studies have arrived at similar conclusions [74,75] , including the study by Hurlstone et al, who compared magnified chromoendoscopic surveillance in 350 UC patients and 350 disease-extent matched controls on traditional surveillance using random biopsies. Sixty-nine dysplastic lesions were identified by chromoendoscopy, compared with only 24 dysplastic lesions in the traditional surveillance group (P < 0.001).…”

Section: Endoscopic Surveillance In Ibdmentioning

confidence: 86%

Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies

Lakatos¹,

Lakatos²

2008

WJG

353

227

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Since the first report of an inflammatory bowel disease (IBD) case associated with colorectal cancer (CRC) by Crohn and Rosenberg [1] , significant efforts have been made to elucidate this presumed association. Nowadays, the association between IBD and the increased risk for CRC is widely accepted. Although CRC, complicating ulcerative colitis and Crohn's disease, accounts only for 1%-2% of all cases of CRC in the general population, it is considered a serious complication of the disease and accounts for approximately 10%-15% of all deaths in IBD patients [2] . The age at diagnosis of CRC associated with IBD is 15-20 years earlier compared to sporadic cancers. In the meta-analysis by Eaden et al [3] , the average age at diagnosis was 43.2 years. Similarly, in a recent publication from Eastern Europe [4] , it was found to be 50.9 years, 10-15 years younger compared to sporadic CRC cases from the same area (62.2 years) [5] . According to US [6] and Canadian [7] publications, almost two-thirds of the affected patients were males, yet results are conflicting [4,8] . In addition, the frequency of multiple CRCs is higher than in patients with sporadic CRC [9] .The increased risk of CRC in UC is almost a universal finding [3,[10][11][12][13] , yet the extent of this risk varies considerably with differences in study design and geographic area. The initial reports were published by tertiary gastroenterology centers, thus the high risk detected might have been a consequence of referral bias and overinterpretation due to the high percentage of extensive and chronically active cases in these cohorts. Results of population-based studies are more reliable; however, several geographical and ethnic differences have been noted.The report of the meta-analysis by Eaden et al [3] in 2001 was one of several milestones in this subject. The incidence of UC-associated CRC was estimated based on 116 articles involving 54 478 patients in whom 1698 CRC cases were detected. This was a mixture of referral center-based, hospital-based, and population-based studies of variable methodological qualities and levels of detail. The reported incidence was higher in the US AbstractThe risk of colorectal cancer for any patient with ulcerative colitis is known to be elevated, and is estimated to be 2% after 10 years, 8% after 20 years and 18% after 30 years of disease. Risk factors for cancer include extent and duration of ulcerative colitis, primary sclerosing cholangitis, a family history of sporadic colorectal cancer, severity of histologic bowel inflammation, and in some studies, young age at onset of colitis. In this review, the authors discuss recent epidemiological trends and causes for the observed changes. Population-based studies published within the past 5 years suggest that this risk has decreased over time, despite the low frequency of colectomies. The crude annual incidence rate of colorectal cancer in ulcerative colitis ranges from approximately 0.06% to 0.16% with a relative risk of 1.0-2.75. The exact mechanism for this chang...

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Section: Endoscopic Surveillance In Ibdmentioning

confidence: 86%

Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies

Lakatos¹,

Lakatos²

2008

WJG

353

227

View full text Add to dashboard Cite

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“…However, the standard strategy of surveillance colonoscopy seems to be associated with risks such as bleeding and lower cost-effectiveness. Several reports have indicated that chromoendoscopy with targeted mucosal biopsies was superior to the standard strategy for detecting dysplasia in IBD patients [59,60]. Although this is a time-saving and cost-effective method, it requires the endoscopist to possess a certain skill and experience level [61].…”

Section: Surveillancementioning

confidence: 99%

“…Most reports on surveillance colonoscopy using IEE for colonic IBD (especially UC) have investigated NBI, indigo carmine chromoendoscopy and methylene blue chromoendoscopy [59,60,[62][63][64][65][66][67][68]. The data available on AFIbased colitis surveillance in UC patients is limited at the present time [65,69,70].…”

Section: Surveillancementioning

confidence: 99%

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

Moriichi

Fujiya

Okumura

2016

Clin J Gastroenterol

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Image-enhanced endoscopy (IEE) has been developed and is applied in the clinical setting throughout the world. Most reports regarding IEE have evaluated the efficacy of narrow-band imaging (NBI) in the diagnosis of gastrointestinal disorders. Although autofluorescence imaging (AFI) is a form of IEE, its usefulness remains unclear. The present review focused on the efficacy of AFI in the diagnosis of colorectal disease, particularly neoplasia and ulcerative colitis (UC). AFI-based diagnoses are made via the subjective judgment of the color on the monitor. The efficacy of AFI in detection and differentiation in patients with colorectal neoplastic lesions remains controversial, which may be dependent on the study design and the diagnostic procedures. Although the number of the reports related to UC is very small, most suggest that AFI is effective in UC patients. AFI is distinct from other modalities in that it can quantitatively assess the lesion based on the fluorescence intensity without any morphological assessments. AFI could be useful for patients with colorectal disease.Keywords Autofluorescence imaging (AFI) Á Colorectal neoplasia Á Ulcerative colitis (UC) Á Colitis-associated cancer Á Narrow-band imaging (NBI) Á Image-enhanced endoscopy (IEE) Á White light endoscopy (WLE)

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“…Magnifying or high-resolution endoscopy after spraying of dye (indigo carmine, methylene blue, crystal violet) to high light architectural irregularities improves sensitivity of examination of surface mucosa especially when dysplastic changes are subtle, facilitates discovery of dysplasia/CC, and allows targeted biopsies [68][69][70][71]. The dye not only enhances the structural details of the mucosa and pit patterns (openings of glandular pits), but also provides better correlation between endoscopic assessment of degree and extent of inflammation and histopathologic findings compared to conventional endoscopy [33,68,71]. The pit pattern correlates with the type of dysplasia [32,69,70,72,73].…”

Section: Surveillancementioning

confidence: 99%

Ulcerative colitis and cancer

Kulaylat

Dayton

2010

Journal of Surgical Oncology

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Patients with ulcerative colitis (UC) are at an increased risk for the development of colorectal cancer (CRC). Unlike sporadic CRC, the cancer in UC patients arises from a focal or multifocal dysplastic mucosa in areas of inflammation. The clinical features of UC-associated cancer are similar to those found in patients with hereditary non-polyposis colorectal cancer. As with other varieties of CRC, UC-associated cancer exhibits a variety of genetic and molecular changes/abnormalities. These abnormalities are however clustered in areas of mucosae with histological abnormalities. The magnitude and timing of these changes are however significantly different. Surveillance and identification of patients at risk for cancer are a challenging problem.

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Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis

Cited by 797 publications

References 25 publications

Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies

Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

Ulcerative colitis and cancer

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