Methyldopa and Depression

Fullerton, Andrew; Morton-Jenkins, D.

doi:10.1136/bmj.1.5329.538-c

Cited by 22 publications

(5 citation statements)

References 2 publications

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“…Sourkes (1) first reported its basic ability to inhibit the decarboxylation of dopa in an in vitro system. In animal studies, it has been found to decrease the CNS concentration of serotonine (2), dopamine, and norepinephrine (3,4) and, in clinical practice, to induce sedation (5-7), depression (8)(9)(10) and toxic psychosis (11,12). The first clinical trials did not establish its efficacy in the treatment of schizophrenia (13)(14)(15)(16)(17), periodic catatonia (18) or mania (19).…”

mentioning

confidence: 99%

α-Methyldopa—Chlorpromazine Combination in Schizophrenic Patients

Chouinard¹,

Annable²

1976

Neuropsychobiology

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In a double-blind, controlled clinical study, lasting 8 weeks, 55 hospitalized schizophrenic patients were randomly assigned to one of the five drug treatments: 600 mg chlorpromazine/day, 300 mg chlorpromazine/day, 300 mg chlorpromazine-250 mg α-methyldopa/day, 300 mg chlorpromazine-500 mg α-methyldopa/day, 300 mg chlorprom-azine-750 mg α-methyldopa/day. The results showed that all five treatments were signifi-cantly effective in treating schizophrenic behavior. The dose-response relationship for the different doses of α-methyldopa in combination with chlorpromazine, suggested an optimal response to 300 mg chlorpromazine-500 mg α-methyldopa.

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confidence: 99%

α-Methyldopa—Chlorpromazine Combination in Schizophrenic Patients

Chouinard¹,

Annable²

1976

Neuropsychobiology

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“… 6 , 27 However, some studies have not shown any differences in adverse events, when comparing fluoxetine with other drugs, 28 - 30 ; (6) methyldopa, which presents bradycardia and depression in the elderly, with level of evidence = 5. 6 , 31 , 32 However, some studies showed no differences in adverse events, when comparing methyldopa with other drugs; 33 , 34 (7) nifedipine presents hypotension and constipation, with level of evidence = 2; 6 , 35 - 37 (8) thioridazine is a typical neuroleptic with great potential for extrapyramidal and central nervous system symptoms, with level of evidence = 5; 6 , 38 (9) promethazine has anticholinergic effects, with level of evidence = 3; 38 , 39 and (10) ferrous sulfate, which at doses greater than 325 mg/day may increase constipation, with level of evidence = 5. 6 …”

Section: Discussionmentioning

confidence: 99%

“…6,27 However, some studies have not shown any differences in adverse events, when comparing fluoxetine with other drugs, [28][29][30] ; (6) methyldopa, which presents bradycardia and depression in the elderly, with level of evidence = 5. 6,31,32 However, some studies showed no differences in adverse events, when comparing methyldopa with other drugs; 33,34 (7) nifedipine presents hypotension and constipation, with level of evidence = 2;…”

mentioning

confidence: 99%

Beers-Fick criteria and drugs available through the Farmácia Dose Certa program

Lucchetti¹,

Lucchetti²,

Pires³

et al. 2011

Sao Paulo Med. J.

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Certa program that might be inappropriate for elderly people and the levels of evidence for each drug included were assessed. RESULTS:Among the available drugs, 10 (25.6%) were included within the Beers-Fick criteria. The drugs selected were: amitriptyline, cimetidine, diazepam, digoxin, fluoxetine, methyldopa, nifedipine, promethazine, thioridazine and ferrous sulfate. CONCLUSION:The list of drugs available within the Farmácia Dose Certa program may be considered appropriate for the general population, but not completely for the elderly population. Adjusting this list to the pharmacological aspects of aging will reduce the risks of drug interactions, falls, mental confusion and excessive sedation that result from drugs that are considered inappropriate for consumption by elderly people.RESUMO CONTEXTO E OBJETIVO: Programa Dose Certa é programa estadual para disponibilizar medicamentos de forma gratuita à população do Estado de São Paulo que é referência nacional no assunto. O segmento de idosos na população assistida merece atenção especial quanto aos fármacos adequados a este segmento etário. O objetivo foi avaliar as drogas no programa que são impróprias para idosos. TIPO DE ESTUDO E LOCAL:Estudo descritivo avaliando a distribuição de medicamentos no estado de São Paulo.MÉTODOS: Seguindo-se os critérios propostos por Beers e Fick (medicamentos ou classes deles que deveriam ser evitados em idosos, independentemente do diagnóstico ou da condição clínica, devido ao alto risco de efeitos colaterais e pela existência de outros fármacos mais seguros), avaliaram-se quais medicamentos do programa Dose Certa são impróprios para idosos e os níveis de evidência para cada medicamento incluído.RESULTADOS: Dos medicamentos disponíveis, 10 (25,6%) foram incluídos nos critérios de Beers-Fick: amitriptilina, cimetidina, diazepam, digoxina, fluoxetina, metildopa, nifedipina, prometazina, tiorodazida e sulfato ferroso.conclusão: A lista de fármacos disponível no Programa Dose Certa pode ser considerada apropriada para a população em geral, mas não totalmente para idosos. Adequá-los a aspectos farmacológicos do envelhecimento reduzirá riscos de interações medicamentosas, quedas, confusão mental e sedação excessiva decorrente de medicamentos considerados impróprios para o consumo de idosos.

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“…Insomnia, nightmares and hallucinations may also occur with depression occasionally (72,75). The combination of methyldopa with other drugs can cause neuropsychiatrie problems: hallucinations with pargyline (81); nightmares or depression with Rauwolfia (82); agitation with amitriptyline (83), and puerperal depression and hallucination with phenothiazines (84). In general, the onset of methyldopa-induced depression seems easier to recognize than reserpine-induced depression, probably because the former has a more readily identifiable symptom such as tiredness.…”

Section: Methyldopamentioning

confidence: 99%

Drug-Induced Mood Disorders

Ananth¹,

Ghadirian²

1980

Int Pharmacopsychiatry

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Various drugs including antihypertensives, anxiolytics, antibiotics, antidepressants, corticosteroids, choline, indomethacin, levodopa, metronidazole, neuroleptics, oral contraceptives, sulphonamides and physostigmine have been reported to produce depression as a side effect. Clinically, these drug-induced depressions may go unnoticed and thus create therapeutic problems. Although causal relationship is difficult to establish, depression occurring during the course of drug treatment needs an evaluation of all the medications that the patient has been receiving. We believe that postpsychotic depressions include three types of depression: pendular depression — primarily disease related; chronic depression - primarily environment related, and amine-depletion depression - drug related. Thus, drug-induced depressions constitute a subgroup of postpsychotic depression. Clinically, it is essential to carefully monitor patients receiving drugs known to produce depression. Thus, prompt recognition of the drug-induced depressions may assist in initiating proper therapeutic measures.

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Methyldopa and Depression

Abstract: BDICAL JHURNAL _~~~~~~~~~~~~~~~~~~~EIA of patients requiring these should be few, and as long as penicillin is effective should be preferred to the use of other antibiotics.-I am, etc.,

Cited by 22 publications

References 2 publications

α-Methyldopa—Chlorpromazine Combination in Schizophrenic Patients

α-Methyldopa—Chlorpromazine Combination in Schizophrenic Patients

Beers-Fick criteria and drugs available through the Farmácia Dose Certa program

Drug-Induced Mood Disorders

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