Methylation status of MGMT gene promoter in meningiomas

Methylation of O6-Methyl Guanine Methyltransferase Gene Promoter in Meningiomas - Comparison between Tumor Grades I, II, and III

“…In another study Yanli liu et al (2005) reported the status of aberrant MGMT methylation in 6% ( 1/16) of grade I,5% (1/19) of grade II, and 8%(1/13) of grade III tumors. In the Robles et al (2008), none of the meningioma samples showed MGMT promoter methylation. In the present study, the frequency of MGMT methylation was higher than that previously reported.…”

In vitro testing to a panel of potential chemotherapeutics and current concepts of chemotherapy in benign meningiomas

“…However, none of the benign meningiomas showed MGMT gene promoter methylation [36]. Based on these data, there is no biological rational to suggest TMZ as an agent with significant anti-meningioma activity.…”

Advances in meningioma therapy

“…Interferon alfa-2b may also have some activity [44]. Temozolomide has not shown any evidence of effi cacy against these tumors [45], perhaps because the DNA repair enzyme methylguanine methyltransferase is active in these tumors [46]. Irinotecan proved ineffective in a phase 2 trial [47].…”