Methylation Pattern of the IFN-γ Gene in Human Dental Pulp

Bioinformatics, Interaction Network Analysis, and Neural Networks to Characterize Gene Expression of Radicular Cyst and Periapical Granuloma

“…Because the RCs and PGs are a result of an inflammatory process in consequence to root canal infection, it is natural that the research to differentiate both lesions focused first in inflammatory markers (1,4,19,42). In addition, it was observed that the proliferation of epithelial cell rests is associated with ICALs (1).…”

“…As in several diseases, ICAL has been related to many forms of controlling gene expression (4,5,(17)(18)(19). However, most of these studies focused on isolated genes or metabolic pathways.…”

FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

“…Polymorphisms in disease-relevant genes, such as cytokines and matrix metalloproteinases, have been shown to be associated with pulpal and periapical pathologies (10)(11)(12). Moreover, there has been some evidence pointing to the hypothesis that epigenetic factors may also play an important role in pulpal and periapical disease (15,16).…”

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“…[32] Methylation patterns may be different between healthy and inflamed dental pulp. [33] Histone modification Post-translational modification of core histones, by either condensing or relaxing chromatin, regulates gene transcription making it a crucial epigenetic mechanism. The basic unit of chromatin, the nucleosome, consists of a DNA segment and eight core histones, making it a rigid structure.…”

“…[61] Periodontitis infected pulp and periodontal tissue may alter gene expression patterns of inflammatory cytokines. [70][71][72][73]33,75] Therefore, these epigenetic biomarkers are to be determined for prevention and treatment of dental diseases. The link between inflammation and oral cancer is well established, and the connection between bacterial infection and inflammation is evident.…”