Methylation Pattern of IFNG in Periapical Granulomas and Radicular Cysts

Campos, Kelma; Gomes, Carolina Cavaliéri; Correia-Silva, Jeane de Fátima; Farias, Lucyana Conceição; Fonseca–Silva, Thiago; Bernardes, Vanessa Fátima; Pereira, Cláudia Maria; Gomez, Ricardo Santiago

doi:10.1016/j.joen.2012.12.026

Cited by 19 publications

(13 citation statements)

References 31 publications

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“…Polymorphisms in disease-relevant genes, such as cytokines and matrix metalloproteinases, have been shown to be associated with pulpal and periapical pathologies (10)(11)(12). Moreover, there has been some evidence pointing to the hypothesis that epigenetic factors may also play an important role in pulpal and periapical disease (15,16).…”

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confidence: 99%

“…It has been proposed that the expression and responsiveness of several inflammatory mediators are programmed through epigenetic mechanisms, such as DNA methylation (18)(19)(20). Recently, DNA methylation of the IFNG gene, which encodes interferon gamma, was suggested to contribute to differential gene transcription and protein levels of this cytokine in periapical granulomas and radicular cysts (16).…”

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confidence: 99%

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FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

Campos

Franscisconi

Okehie

et al. 2015

Journal of Endodontics

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confidence: 99%

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confidence: 99%

FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

Campos

Franscisconi

Okehie

et al. 2015

Journal of Endodontics

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“…DNA methylation is one such host genetic factor that may influence the risk of developing AP, as it may be involved in differential transcription and expression of AP‐relevant genes (Campos et al . , , ). In a previous study, partial or total methylation of the Interferon‐gamma ( IFNG ) gene promoter was detected in radicular cysts and periapical granulomas.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have also reported the involvement of DNA methylation events in AP‐relevant genes, suggesting epigenetic regulation as a potential regulatory mechanism in AP (Campos et al . , , , Mehrazarin et al . ).…”

Section: Introductionmentioning

confidence: 98%

DNA methylation profiles of immune response‐related genes in apical periodontitis

et al. 2018

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Differential methylation profiles of immune response-related genes, such as FADD, CXCL3, IL12B and IL4R, may have an influence on individual AP susceptibility and patient treatment outcomes, through their potential contributions to altered expression of disease-relevant genes. Methylation and/or genetic variations in additional genes may also contribute to the dynamics of AP development and should be considered in future studies.

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“…In another study, evaluation of the global methylation in lichenoid lesions, including OLP, showed no difference compared to the methylation levels in normal mucosa . Although the information regarding DNA methylation in OLP immunoinflammatory response is scarce, such phenomenon is being currently studied in several other inflammatory processes, including inflammatory periapical lesions, systemic lupus erythematosus and Addison's disease . Here, we hypothesise that the DNA methylation profile of genes related to immune response varies according to the clinical forms of OLP, harbouring different DNA methylation patterns when compared to healthy, normal oral mucosa.…”

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confidence: 90%

DNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planus

Cruz

Resende

Lacerda

et al. 2017

J Oral Pathology Medicine

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Background The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune‐mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response‐related genes in the different clinical forms of oral lichen planus. Methods A cross‐sectional study was performed to analyse the DNA methylation patterns in three distinct groups of oral lichen planus: (i) reticular/plaque lesions; (ii) erosive lesions; (iii) normal oral mucosa (control group). After DNA extraction from biopsies, the samples were submitted to digestions by methylation‐sensitive and methylation‐dependent enzymes and double digestion. The relative percentage of methylated DNA for each gene was provided using real‐time polymerase chain reaction arrays. Results Hypermethylation of the STAT5A gene was observed only in the control group (59.0%). A higher hypermethylation of the ELANE gene was found in reticular/plaque lesions (72.1%) compared to the erosive lesions (50.0%). Conclusion Our results show variations in the methylation profile of immune response‐related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis.

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Methylation Pattern of IFNG in Periapical Granulomas and Radicular Cysts

Cited by 19 publications

References 31 publications

FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

DNA methylation profiles of immune response‐related genes in apical periodontitis

DNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planus

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