Methylation of tumour suppressor genes in benign and malignant salivary gland tumours: a systematic review and meta-analysis

Nikolic, Nadja; Čarkić, Jelena; Jaćimović, Jelena; Jakovljević, Aleksandar; Aničić, Boban; Jezdić, Zoran; Milašin, Jelena

doi:10.1080/15592294.2022.2052426

Cited by 3 publications

(2 citation statements)

References 69 publications

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“…A number of molecular changes have already been characterized in SGTs, including gene fusions, 21 mutations, 22 aberrant methylation, 23 and so forth. In the present study, we attempted to assess the expression levels of several markers (miR‐26a, miR‐26b, miR‐191, PLAG1 , HIF2 , and MTDH genes) and estimate whether they can be used in SGT diagnostics and management.…”

Section: Discussionmentioning

confidence: 99%

MiR‐26a and miR‐191 are upregulated while PLAG1 and HIF2 are downregulated in pleomorphic adenomas of the salivary glands compared to Warthin tumors

Carkic,

Nikolic,

Sango

et al. 2024

J Oral Pathology Medicine

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BackgroundSalivary gland tumors (SGTs) are a heterogenous group of pathologies, which still represents a challenge regarding differential diagnosis and therapy. Although histological findings govern SGTs management, detection of molecular alterations is emerging as an effective additional tool. The aim of this study was to analyze the relative expression levels of three micro RNAs (miR‐26a, miR‐26b, and miR‐191), and three pro‐oncogenic molecular markers (PLAG1, MTDH, and HIF2) in SGTs and normal salivary gland (NSG) tissues and evaluate them as potential differential diagnosis markers.MethodsThis cross‐sectional study included 58 patients with SGTs (23 pleomorphic adenomas, 27 Warthin tumors, and 8 malignant SGTs) and 10 controls (normal salivary gland tissues). Relative gene expression levels of all investigated molecules were determined by reverse transcriptase‐real‐time polymerase chain reaction.ResultsAll three micro RNAs exhibited highest expression levels in benign SGTs, whereas miR‐26a And miR‐191 were significantly more expressed in PAs compared to WTs (p = 0.045 and p = 0.029, respectively). PLAG1 And HIF2 were both overexpressed in WTs compared to PAs (p = 0.048 and p = 0.053, respectively). Bioinformatic analysis suggested that all investigated micro RNAs function as negative regulators of MTDH.ConclusionThe results of this study suggest that all three micro RNAs have a considerable negative impact on MTDH oncogene expression in malignant tumors, while the differences between levels of miR‐26a, miR‐191, PLAG1, and HIF2 in PA and WT represent possible differential diagnosis markers.

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Section: Discussionmentioning

confidence: 99%

MiR‐26a and miR‐191 are upregulated while PLAG1 and HIF2 are downregulated in pleomorphic adenomas of the salivary glands compared to Warthin tumors

Carkic,

Nikolic,

Sango

et al. 2024

J Oral Pathology Medicine

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“…It is confirmed to be a pivotal factor for many cellular processes, including genomic silencing, X chromosome inactivation, cellular differentiation, and embryonic development. [2][3][4][5] Anomalous DNA methylation levels at regional and global genes will speed up tumorigenesis and cause various types of cancers, such as lung, breast, and liver cancers. 6 The methylation levels of regional and global genes are increasingly considered as liquid biopsy biomarkers for the early diagnosis of cancer owing to the fact that methylated DNA can be released into the body fluids.…”

Section: Introductionmentioning

confidence: 99%

A ratiometric fluorescence assay for the detection of DNA methylation based on an alkaline phosphatase triggered in situ fluorogenic reaction

Zhang,

Su,

Zhao

et al. 2024

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Role of Histone Deacetylases in the Pathogenesis of Salivary Gland Tumors and Therapeutic Targeting Options

Manou

Kanakoglou

Loupis

et al. 2023

IJMS

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Salivary gland tumors (SGTs) comprise a rare and heterogenous category of benign/malignant neoplasms with progressively increasing knowledge of the molecular mechanisms underpinning their pathogenesis, poor prognosis, and therapeutic treatment efficacy. Emerging data are pointing toward an interplay of genetic and epigenetic factors contributing to their heterogeneity and diverse clinical phenotypes. Post-translational histone modifications such as histone acetylation/deacetylation have been shown to actively participate in the pathobiology of SGTs, further suggesting that histone deacetylating factors (HDACs), selective or pan-HDAC inhibitors (HDACis), might present effective treatment options for these neoplasms. Herein, we describe the molecular and epigenetic mechanisms underlying the pathology of the different types of SGTs, focusing on histone acetylation/deacetylation effects on gene expression as well as the progress of HDACis in SGT therapy and the current status of relevant clinical trials.

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Methylation of tumour suppressor genes in benign and malignant salivary gland tumours: a systematic review and meta-analysis

Cited by 3 publications

References 69 publications

MiR‐26a and miR‐191 are upregulated while PLAG1 and HIF2 are downregulated in pleomorphic adenomas of the salivary glands compared to Warthin tumors

MiR‐26a and miR‐191 are upregulated while PLAG1 and HIF2 are downregulated in pleomorphic adenomas of the salivary glands compared to Warthin tumors

A ratiometric fluorescence assay for the detection of DNA methylation based on an alkaline phosphatase triggered in situ fluorogenic reaction

Role of Histone Deacetylases in the Pathogenesis of Salivary Gland Tumors and Therapeutic Targeting Options

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