Methylation of the dopamine D2 receptor (DRD2) gene promoter in women with a bulimia-spectrum disorder: Associations with borderline personality disorder and exposure to childhood abuse

Groleau, Patricia; Joober, Ridha; Israël, Mimi; Zeramdini, Nadia; DeGuzman, Rosherrie; Steiger, Howard

doi:10.1016/j.jpsychires.2013.10.003

Cited by 72 publications

(59 citation statements)

References 34 publications

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“…More generally, our results are in agreement with several studies showing that BPD, certainly as a result of early life adversities, is definitely associated with broad epigenetic signatures involving several genes interacting together and genes that may be highlighted by a methylome‐wide association study (Dammann et al ; Groleau et al ; Perroud et al , ; Steiger et al ; Teschler et al ; Thaler et al ).…”

Section: Discussionsupporting

confidence: 92%

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Borderline personality disorder and childhood maltreatment: a genome‐wide methylation analysis

Prados

Stenz

Courtet

et al. 2015

Genes Brain and Behavior

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Early life adversity plays a critical role in the emergence of borderline personality disorder (BPD) and this could occur through epigenetic programming. In this perspective, we aimed to determine whether childhood maltreatment could durably modify epigenetic processes by the means of a whole-genome methylation scan of BPD subjects. Using the Illumina Infinium ® HumanMethylation450 BeadChip, global methylation status of DNA extracted from peripheral blood leucocytes was correlated to the severity of childhood maltreatment in 96 BPD subjects suffering from a high level of child adversity and 93 subjects suffering from major depressive disorder (MDD) and reporting a low rate of child maltreatment. Several CpGs within or near the following genes (IL17RA, miR124-3, KCNQ2, EFNB1, OCA2, MFAP2, RPH3AL, WDR60, CST9L, EP400, A2ML1, NT5DC2, FAM163A and SPSB2) were found to be differently methylated, either in BPD compared with MDD or in relation to the severity of childhood maltreatment. A highly relevant biological result was observed for cg04927004 close to miR124-3 that was significantly associated with BPD and severity of childhood maltreatment. miR124-3 codes for a microRNA (miRNA) targeting several genes previously found to be associated with BPD such as NR3C1. Our results highlight the potentially important role played by miRNAs in the etiology of neuropsychiatric disorders such as BPD and the usefulness of using methylome-wide association studies to uncover such candidate genes. Moreover, they offer new understanding of the impact of maltreatments on biological processes leading to diseases and may ultimately result in the identification of relevant biomarkers.

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Section: Discussionsupporting

confidence: 92%

“…In BPD subjects, childhood maltreatment and its severity correlated with higher methylation levels of two promoters of the BDNF gene (Perroud et al ). Other studies found that BPD was associated with a different pattern of methylation of several genes including HTR2A , MAOA , BDNF , DRD2 and COMT (Dammann et al ; Groleau et al ; Steiger et al ; Thaler et al ).…”

mentioning

confidence: 99%

Borderline personality disorder and childhood maltreatment: a genome‐wide methylation analysis

Prados

Stenz

Courtet

et al. 2015

Genes Brain and Behavior

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“…Two of three studies have found epigenetic alterations in the dopamine D2 receptor gene, of small‐to‐large effect size, in women with AN and/or BN (see Table ). One of these studies found more robust effects in the subgroup of women with BN who had an abuse history or a personality disorder diagnosis (Groleau et al., ). These preliminary findings await classification, but align with emerging data from neurobiological studies suggesting dopaminergic disturbances in patients recovered from AN, and to some extent, BN (see Table ).…”

Section: Formal Tests Of Gene‐environment Interplaymentioning

confidence: 99%

Research Review: What we have learned about the causes of eating disorders – a synthesis of sociocultural, psychological, and biological research

Culbert

Racine

Klump

2015

Child Psychology Psychiatry

462

339

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Multiple biopsychosocial influences are implicated in eating disorders and/or disordered eating symptoms and several can now be considered established risk factors. Data suggest that psychological and environmental factors interact with and influence the expression of genetic risk to cause eating pathology. Additional studies that examine risk variables across multiple levels of analysis and that consider specific transactional processes amongst variables are needed to further elucidate the intersection of sociocultural, psychological, and biological influences on eating disorders.

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“…214 In the case of BN and related psychopathology, no difference between women with bulimic spectrum disorder and healthy controls was observed in DRD2 promoter methylation; however, a subgroup of participants with bulimic spectrum disorders with comorbid psychopathology had increased DRD2 promoter methylation in this preliminary study. 215 …”

Section: Study Of Epigenetic Changes and Gene Regulation Linked Tomentioning

confidence: 99%

Genetics and epigenetics of eating disorders

Yılmaz¹,

Hardaway²,

Bulik³

2015

AGG

131

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Eating disorders (EDs) are serious psychiatric conditions influenced by biological, psychological, and sociocultural factors. A better understanding of the genetics of these complex traits and the development of more sophisticated molecular biology tools have advanced our understanding of the etiology of EDs. The aim of this review is to critically evaluate the literature on the genetic research conducted on three major EDs: anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). We will first review the diagnostic criteria, clinical features, prevalence, and prognosis of AN, BN, and BED, followed by a review of family, twin, and adoption studies. We then review the history of genetic studies of EDs covering linkage analysis, candidate gene association studies, genome-wide association studies, and the study of rare variants in EDs. Our review also incorporates a translational perspective by covering animal models of ED-related phenotypes. Finally, we review the nascent field of epigenetics of EDs and a look forward to future directions for ED genetic research.

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Methylation of the dopamine D2 receptor (DRD2) gene promoter in women with a bulimia-spectrum disorder: Associations with borderline personality disorder and exposure to childhood abuse

Cited by 72 publications

References 34 publications

Borderline personality disorder and childhood maltreatment: a genome‐wide methylation analysis

Borderline personality disorder and childhood maltreatment: a genome‐wide methylation analysis

Research Review: What we have learned about the causes of eating disorders – a synthesis of sociocultural, psychological, and biological research

Genetics and epigenetics of eating disorders

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