Methylation of serotonin regulating genes in cord blood cells: modulation by maternal metabolic parameters and correlation with methylation in peripheral blood cells during childhood and adolescence
Ivona Bečeheli,
Marina Horvatiček,
Maja Perić
et al.
Abstract:Background
Serotonin (5-hydroxytryptamine, 5-HT) signaling is involved in neurodevelopment, mood regulation, energy metabolism, and other physiological processes. DNA methylation plays a significant role in modulating the expression of genes responsible for maintaining 5-HT balance, such as 5-HT transporter (SLC6A4), monoamine oxidase A (MAOA), and 5-HT receptor type 2A (HTR2A). Maternal metabolic health can influence long-term outcomes in offspring, with DNA methylation mediating these effects. We investigat… Show more
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