Methylation‐based estimated biological age and cardiovascular disease

Lind, Lars; Ingelsson, Erik; Sundström, Johan; Siegbahn, Agneta; Lampa, Erik

doi:10.1111/eci.12872

Cited by 81 publications

(60 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…33 Other factors, partly related to genomic stability, might contribute significantly to biological age and cardiovascular risk. 34,35 These considerations underline the importance of evaluating the profiles of functional status and frailty in geriatric patients, but certainly do not undermine the role of plasma cholesterol as a cardiovascular risk factor, even in the older population, as clearly pointed out in large meta-analysis studies. 27 Small dense LDL was recently identified as a biomarker for secondary prevention in older adults.…”

Section: Cholesterol and Cardiovascular Risk In Older Patientsmentioning

confidence: 98%

See 1 more Smart Citation

Management of high cholesterol levels in older people

Bertolotti

Lancellotti

Mussi

2019

Geriatrics Gerontology Int

View full text Add to dashboard Cite

The management of hypercholesterolemia in older adults still represents a challenge in clinical medicine. The pathophysiological alterations of cholesterol metabolism associated with aging are still incompletely understood, even if epidemiological evidence suggests that serum cholesterol levels increase with ongoing age, possibly with a plateau after the age of 80 years. Age is also one of the main determinants of cardiovascular disease, according to all cardiovascular risk estimate tools. Cholesterol‐lowering treatment, therefore, would be expected to bring significant protection, even in these patients. Unfortunately, direct experimental evidence is extremely limited, particularly in the very old age strata of the population; a clinical benefit still seems to be present, but the risk for drug‐related adverse events is clearly higher. At any rate, at the present time, definite guidelines for the correct management of hypercholesterolemia in older patients are not available. Therefore, the decision whether or not a pharmacological treatment should be set up, and the choice of the drug, need to be tailored to the individual patient, and requires accurate clinical judgment. The specific aspects of frailty and disability, along with the actual age of the patients, have to be considered together, with a comprehensive assessment approach. The present review summarizes the evidence regarding the modifications of cholesterol metabolism in older patients, the impact of lipid‐lowering drugs on cardiovascular outcomes and focuses on the considerations that can help to define the most appropriate treatment strategy, in view of the individual functional profile. Geriatr Gerontol Int 2019; 19: 375–383.

show abstract

Section: Cholesterol and Cardiovascular Risk In Older Patientsmentioning

confidence: 98%

“…In particular, the presence of low levels of high‐density lipoprotein cholesterol, a recognized risk factor for cognitive impairment, was considered . Other factors, partly related to genomic stability, might contribute significantly to biological age and cardiovascular risk …”

Section: Cholesterol and Cardiovascular Risk In Older Patientsmentioning

confidence: 99%

Management of high cholesterol levels in older people

Bertolotti

Lancellotti

Mussi

2019

Geriatrics Gerontology Int

View full text Add to dashboard Cite

show abstract

“…We read with interest the research article by Lind et al recently published in the European Journal of Clinical Investigation (ESCI), in which the authors investigated the potential association between DNA methylation‐based estimation of biological age and cardiovascular disease. We would congratulate the authors since, among other outstanding papers, this article was awarded by the ESCI Council as the Best Clinical Research Article published in the European Journal of Clinical Investigation from November 2017 to October 2018.…”

mentioning

confidence: 99%

“…The most striking feature of the epigenetic clocks is their ability to predict all‐cause mortality independently of traditional risk factors . More specifically, two other studies addressed cause‐specific mortality to epigenetic clock, showing a stronger prediction for cancer‐related rather than CV mortality . Conversely, telomeres length seems to equally predict cancer and CV mortality .…”

mentioning

confidence: 99%

“…9 More specifically, two other studies addressed cause-specific mortality to epigenetic clock, showing a stronger prediction for cancer-related rather than CV mortality. 1,10,11 Conversely, telomeres length seems to equally predict cancer and CV mortality. 12 Alongside, transcriptomic-and proteomic-based predictors are emerging as potential biomarkers of ageing.…”

mentioning

confidence: 99%

See 1 more Smart Citation

New insights into the role of DNA methylation in cardiovascular disease

Bardi

Carbone

Montecucco

2018

Eur J Clin Investigation

View full text Add to dashboard Cite

Associations Between Depression, Arterial Stiffness, and Metabolic Syndrome Among Adults in the UK Biobank Population Study

et al. 2020

View full text Add to dashboard Cite

IMPORTANCE Previous research has linked a history of depression with arterial stiffness (AS) during midlife. OBJECTIVE To assess the association of depression with elevated midlife AS and to investigate the extent to which this association is mediated via metabolic syndrome (MetS). DESIGN, SETTINGS, AND PARTICIPANTS This population-based retrospective cohort study analyzed data collected between March 2006 and December 2010 from 124 445 participants aged 40 to 69 years from the UK Biobank. Participants without data on AS at baseline (n = 332 780) or who reported a previous diagnosis of cardiovascular disease (n = 45 374) were not eligible. Data analysis was performed from May to August 2019. EXPOSURES Lifetime history of depression was assessed via verbal interview and linked hospital-based clinical depression diagnosis. Metabolic syndrome was defined as the presence of 3 or more of hypertension, dyslipidemia, hyperglycemia, hypertriglyceridemia, and unhealthy waist circumference. MAIN OUTCOMES AND MEASURES Peripherally assessed AS index (ASI) using digital photoplethysmography. RESULTS Of 124 445 included participants with ASI assessed, 71 799 (57.7%) were women, and the mean (SD) age was 56 (8) years. A total of 10 304 participants (8.3%) reported a history of depression. Study findings indicated a significant direct association between depression and ASI levels (β = 0.25; 95% CI, 0.17-0.32). A significant indirect association was also observed between depression and ASI levels (β = 0.10; 95% CI, 0.07-0.13), indicating that 29% of the association of depression with ASI was mediated by MetS. The proportion of mediation increased to 37% when C-reactive protein was added to the MetS criteria (direct association: β = 0.21; 95% CI, 0.15-0.28; indirect association: β = 0.13; 95% CI, 0.10-0.17). Concerning components of MetS, the strongest indirect association was for waist circumference, accounting for 25% of the association between depression and ASI levels (direct association: β = 0.26; 95% CI, 0.18-0.34; indirect association: β = 0.09; 95% CI, 0.06-0.11). Among men, hypertriglyceridemia accounted for 19% of the association between depression and ASI (direct association: β = 0.22; 95% CI, 0.05-0.40; indirect association: β = 0.05; 95% CI, 0.02-0.08). CONCLUSIONS AND RELEVANCE One-third of the association of depression with elevated ASI levels during midlife may be accounted for by combined MetS and inflammatory processes. Unhealthy waist circumference and hypertriglyceridemia emerged as the most important potential targets for preventive interventions within women and men, respectively.

show abstract

Methylation‐based estimated biological age and cardiovascular disease

Abstract: DNA methylation-based estimation of "biological age" per Horvath was associated with incident cardiovascular disease.

Cited by 81 publications

References 24 publications

Management of high cholesterol levels in older people

Management of high cholesterol levels in older people

New insights into the role of DNA methylation in cardiovascular disease

Associations Between Depression, Arterial Stiffness, and Metabolic Syndrome Among Adults in the UK Biobank Population Study

Contact Info

Product

Resources

About