Methyl β-cyclodextrin as a booster for the extraction for Olea europaea leaf polyphenols with a bio-based deep eutectic solvent

Athanasiadis, Vassilis; Grigorakis, Spyros; Lalas, Stavros; Makris, Dimitris P.

doi:10.1007/s13399-017-0283-5

Cited by 42 publications

(20 citation statements)

References 38 publications

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“…The maximum Y TP that was attained at 80 • C was 98.77 ± 2.00 mg GAE g −1 dm ( Table 5). This level is close to the 109.93 mg GAE g −1 dm reported by previous studies on OLL from the same variety, produced using a glycerol/glycine DES, although it has also been demonstrated that a combination of that DES with methyl β-cyclodextrin might provide even higher Y TP (116.58 mg GAE g −1 dm) [32]. A series of extraction methodologies involving intensification, such as microwave and ultrasound irradiation, as well as steam explosion and conventional volatile solvents, showed that Y TP from OLL might vary from 20.9 to 144.2 mg GAE g −1 dm [33].…”

Section: Temperature Effectssupporting

confidence: 86%

“…By contrast, OLL polyphenol extraction with a blend of methyl β-cyclodextrin and a glycerol/glycine-based DES was shown to have 51 °C as the optimal T [32]. Considering all of the above, it could be argued that OLL extraction might well be performed at 80 °C to further enrich the resulting extract in flavonoids and improve its antioxidant properties.…”

Section: Polyphenolic Compositionmentioning

confidence: 97%

“…Effect of extraction at 80 • C on total polyphenols (Y TP ), total flavonoids (Y TFn ), ferric-reducing power (P R ), and antiradical activity (A AR ) of the extracts produced with La-Gly (5:1), under optimized conditions. By contrast, OLL polyphenol extraction with a blend of methyl β-cyclodextrin and a glycerol/glycine-based DES was shown to have 51 • C as the optimal T [32]. Considering all of the above, it could be argued that OLL extraction might well be performed at 80 • C to further enrich the resulting extract in flavonoids and improve its antioxidant properties.…”

Section: Temperature Effectsmentioning

confidence: 98%

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Green Valorization of Olive Leaves to Produce Polyphenol-Enriched Extracts Using an Environmentally Benign Deep Eutectic Solvent

et al. 2020

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Olive leaves (OLL) are considered to be a highly appreciated bioresource of bioactive polyphenolic phytochemicals, embracing several different structures. However, extraction processes based on deep eutectic solvents (DES) are very limited despite the wide range of techniques developed for the efficient recovery of polyphenols. This study had as objective the development of a simple, green, high-performance extraction methodology for OLL polyphenols, using a recently reported effective DES, composed of L-lactic acid and glycine. Initially, a screening was performed to select the most appropriate L-lactic/glycine molar ratio and process optimization was then carried out with response surface methodology. The optimized process variable values were DES/water (78% w/v), liquid-to-solid ratio of 36 mL g−1, and stirring speed of 500 rounds per minute, and the total polyphenol yield amounted to 97.53 ± 3.54 mg gallic acid equivalents per g dry matter. Extraction with DES at 80 °C did not significantly increase the total polyphenol yield, but it did enhance the total flavonoid yield and antioxidant activity. High-performance liquid chromatography analyses revealed that extraction with the DES resulted in extended oleuropein hydrolysis, to the favor of hydroxytyrosol formation. This finding might have a prospect in using properly tuned DES for polyphenol modification with improved bioactivities.

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Section: Temperature Effectssupporting

confidence: 86%

Section: Polyphenolic Compositionmentioning

confidence: 97%

Section: Temperature Effectsmentioning

confidence: 98%

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Green Valorization of Olive Leaves to Produce Polyphenol-Enriched Extracts Using an Environmentally Benign Deep Eutectic Solvent

et al. 2020

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“…Polyphenol-containing extracts were prepared from OLL by implementing the optimized methodology previously developed in [5]. Briefly, 2.5 g of dried OLL was mixed with 100 mL of 80% (w/v) aqueous DES containing 9% (w/v) methyl β-cyclodextrin (m-β-CD) and extractions were carried out at 70 • C, under continuous stirring at 600 rpm for 280 min.…”

Section: Batch Extraction Procedures and Sample Handlingmentioning

confidence: 99%

“…On the basis of this theoretical background, this examination was carried out to assess the antiradical behaviour of OLL extracts obtained using a novel methodology that involved extraction with a combination of a deep eutectic solvent (DES) with methyl β-cyclodextrin (m-β-CD) as an extraction booster [5]. OLL extracts were also generated without m-β-CD, in order to evaluate the effect of m-β-CD on the antiradical potency of the extracts.…”

Section: Introductionmentioning

confidence: 99%

Effect of Methyl β-cyclodextrin on Radical Scavenging Kinetics of Olive Leaf Extracts and Interactions with Ascorbic Acid

2017

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Abstract:Olive leaf (OLL) extracts contain a high load of antioxidant polyphenols with significant pharmacological potency. In this study, the use of a novel natural deep eutectic solvent enabled the effective extraction of OLL polyphenols and their testing as radical scavengers, in the presence or absence of methyl β-cyclodextrin (m-β-CD), using descriptive kinetics. Testing was extended to include interactions with ascorbic acid-a natural powerful antioxidant-by implementing a response surface methodology. The kinetic study showed that m-β-CD may hinder the radical scavenging effect of OLL extracts, yielding lower stoichiometry upon reaction with the radical probe 2,2-diphenyl-1-picrylhydrazy (DPPH). The extension of the reaction time to determine the total stoichiometry confirmed this effect. As a further concurrence, the interactions of OLL extracts with ascorbic acid showed lower radical scavenging performance in the presence of m-β-CD. These results were discussed on the grounds of the role that m-β-CD may play in similar systems.

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Determination of Binding Strengths of Host‐Guest Complexes in Deep Eutectic Solvents Using Spin Probe Methodology

Cantelli¹,

Franchi²,

Mezzina³

et al. 2021

ChemPhysChem

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Electron paramagnetic resonance (EPR) and spin probe methodologies have been employed to study the complexation properties of cyclodextrins (CDs) and cucurbit[n]urils (CB[n]s) in the deep eutectic solvent (DES) choline chloride‐urea. In the presence of γ‐CD an affinity constant very similar to that measured in water was measured in DES with benzyl‐tert‐butyl nitroxide (BTBN). With β‐CD, complexation of BTBN is significantly depressed, although still maintained. Complexation of TEMPO radical probe by CB[7] or CB[8] was instead almost entirely cancelled in DES. In addition, this methodology enabled for the first time to measure the single rate constants for the association and dissociation processes with CDs in DES.

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Methyl β-cyclodextrin as a booster for the extraction for Olea europaea leaf polyphenols with a bio-based deep eutectic solvent

Cited by 42 publications

References 38 publications

Green Valorization of Olive Leaves to Produce Polyphenol-Enriched Extracts Using an Environmentally Benign Deep Eutectic Solvent

Green Valorization of Olive Leaves to Produce Polyphenol-Enriched Extracts Using an Environmentally Benign Deep Eutectic Solvent

Effect of Methyl β-cyclodextrin on Radical Scavenging Kinetics of Olive Leaf Extracts and Interactions with Ascorbic Acid

Determination of Binding Strengths of Host‐Guest Complexes in Deep Eutectic Solvents Using Spin Probe Methodology

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