2011
DOI: 10.1016/j.taap.2011.01.003
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Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death

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Cited by 23 publications
(16 citation statements)
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“…In the cells, vit B 12 is transferred to the cytoplasm by the lysosomal membrane vit B 12 transporter (LMBRD1) and serves as cofactor for methyl malonylCoA mutase (Mut) and methionine synthase (MS) [21]. Futhermore, vit B 12 deficiency leads to methionine deficiency, which is required for the synthesis of both phospholipids and myelin.…”
Section: Introductionmentioning
confidence: 99%
“…In the cells, vit B 12 is transferred to the cytoplasm by the lysosomal membrane vit B 12 transporter (LMBRD1) and serves as cofactor for methyl malonylCoA mutase (Mut) and methionine synthase (MS) [21]. Futhermore, vit B 12 deficiency leads to methionine deficiency, which is required for the synthesis of both phospholipids and myelin.…”
Section: Introductionmentioning
confidence: 99%
“…High-dose methylcobalamin was also reported to protect cortical neurons against glutamate toxicity [24]. Elevated homocysteine levels have been suggested to be toxic for motor neurons [25], and methylcobalamin protected motor neurons from homocysteine-induced toxicity [26]. These profiles are relevant to ALS patients because plasma homocysteine levels were significantly increased in patients who have shorter time to diagnosis of ALS [27].…”
Section: Discussionmentioning
confidence: 99%
“…However, in one study, B12 alone did not show any effect on homocysteine levels, onset of disease or survival. However, a more recent in vitro study had opposite results, showing better survival against homocysteine toxicity in vitro, in cells pretreated with B12 but not in those treated with folate (75). Furthermore, in one small pre-clinical study, ALS mice were supplemented with Galactooligosaccharides (GOS), a prebiotic that is thought to improve the absorption and synthesis of B Vitamins.…”
Section: Types Of Cam That Pals Commonly Ask Aboutmentioning
confidence: 93%