Methyl Vanillate Ether Derivatives as Future Potential Drug

Abstract

Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a dihydroxybenzoic acid derivative used as a flavouring agent. It is used in the synthesis of various active pharmaceutical ingredients such as Etamivan, Modecainide, Brovanexine, Vanitiolide, Vanyldisulfamide etc. In this paper, novel ether derivatives of vanillic acid were synthesized and tested for potential antibacterial activity. This combinatorial synthesis of novel vanillic acid ether derivatives can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates.

Potential Large-Scale CO2 Utilisation for Salicylic Acid Production via a Suspension-Based Kolbe–Schmitt Reaction in Toluene

“…In contrast, HACAs have significant potential due to their versatile applications including in pharmaceuticals [11][12][13], dyes [14,15], fragrances [16], cosmetics [17,18], food supplements [18,19], and biodegradable plastics [20][21][22]. Increasing the production and the use of durable materials from HACAs offers long-term carbon storage, essential for the CCUS strategy.…”

A critical review of the production of hydroxyaromatic carboxylic acids as a sustainable method for chemical utilisation and fixation of CO2

“…One group of CO 2 -based chemicals with potential high future demands are HACAs, due to the versatility of their possible uses and applications. Notable HACAs include salicylic acids, hydroxynapthoic acids and various halogenated derivatives that may be employed as intermediates or starting material in the pharmaceutical [14][15][16], dye [17,18], fragrance [19], cosmetic [20,21], food [21,22] and bioplastic industry [23][24][25]. Currently, commercial quantities of HACAs are produced via the Kolbe-Schmitt reaction between phenolic compounds and CO 2 .…”