Methyl parathion causes genetic damage in sperm and disrupts the permeability of the blood-testis barrier by an oxidant mechanism in mice

Urióstegui-Acosta, Mayrut; Tello-Mora, Pamela; Solís-Heredia, María de Jesús; Ortega-Olvera, José Mario; Piña-Guzmán, Belem; Martín-Tapia, Dolores; González‐Mariscal, Lorenza; Quintanilla‐Vega, Betzabet

doi:10.1016/j.tox.2020.152463

Cited by 33 publications

(15 citation statements)

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“…The authors coadministred methyl parathion with α-tocopherol, an antioxidant, and observed no biotin infiltration in the adluminal compartment of the seminiferous tubules, whereas in the absence of this antioxidant, permeability of the BTB was observed. The BTB permeability is regulated, among other factors, by tight, adherent and gap junctions present in Sertoli cells, thus indicating a possible toxic mechanism of methyl parathion through impairments in these cells and/or their junctions [48]. In accordance with the previous study, Pisani et al (2016) demonstrated stiffeness of the BTB junctions after exposure to carbendazim, a carbamate fungicide, consequently affecting germ cell migration [49].…”

Section: Sertoli Cellssupporting

confidence: 83%

Pesticides and Male Fertility: A Dangerous Crosstalk

et al. 2021

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In recent decades, an increasing incidence of male infertility has been reported. Interestingly, and considering that pesticides have been used for a long time, the high incidence of this pathological state is concomitant with the increasing use of these chemicals, suggesting they are contributors for the development of human infertility. Data from literature highlight the ability of certain pesticides and/or their metabolites to persist in the environment for long periods of time, as well as to bioaccumulate in the food chain, thus contributing for their chronic exposure. Furthermore, pesticides can act as endocrine disrupting chemicals (EDCs), interfering with the normal function of natural hormones (which are responsible for the regulation of the reproductive system), or even as obesogens, promoting obesity and associated comorbidities, like infertility. Several in vitro and in vivo studies have focused on the effects and possible mechanisms of action of these pesticides on the male reproductive system that cause sundry negative effects, even though through diverse mechanisms, but all may lead to infertility. In this review, we present an up-to-date overview and discussion of the effects, and the metabolic and molecular features of pesticides on somatic cells and germinal tissues that affect germ cell differentiation.

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Section: Sertoli Cellssupporting

confidence: 83%

Pesticides and Male Fertility: A Dangerous Crosstalk

et al. 2021

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“…In our analysis, a substantial reduction of several semen parameters emerged, with a significant reduction of ejaculate volume, sperm count and concentration, confirming their negative effects on human spermatogenesis. Generating reactive oxygen species, OPs alter the physiological function of the blood–testis barrier (Urióstegui‐Acosta et al., 2020), producing covalent bonds with the occludens zone 2 (ZO2) (Ortega‐Olvera et al., 2018). The higher mean value of seminal pH in exposed men showed in our analysis is an indirect sign of this process.…”

Section: Discussionmentioning

confidence: 99%

Do environmental and occupational exposure to pyrethroids and organophosphates affect human semen parameters? Results of a systematic review and meta‐analysis

et al. 2021

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Infertility is characterised by the inability to conceive a pregnancy after at least one year of unprotected intercourse (Louis et al., 2013). This clinical condition affects up to 15% of couples (Louis et al., 2013) and, in about 40% of them, the origin is attributable to males (Bhasin et al., 1994). In approximately 31% of cases, infertility is found to be secondary and, therefore, a preventable condition (WHO, 1992).Although it is difficult to demonstrate a definitive correlation between such risk factors and male infertility, Jensen reported that several occupational and environmental exposure to toxins have known or suspected harmful effects on male reproductive functions (Jensen et al., 2006). Undeniably, one of the most studied hazards is pesticide use. Pesticides prevent, destroy or control harmful organisms (pests), protect plants or plant products during production, storage and transport (Sengupta & Banerjee, 2014). Pesticide

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“…They are excellent insecticides, although adverse effects can also occur in humans after exposure. OPs have also shown a worsening impact on fertility, altering the regular function of the blood-testis barrier in mice through oxidative stress, 82 forming covalent bonds with the zonula occludens-2 protein (ZO2). 83 The effect of OPs on semen quality emerged through a recent meta-analysis, where we demonstrated a decline in almost all parameters considered.…”

Section: Discussionmentioning

confidence: 99%

The environmental and occupational influence of pesticides on male fertility: A systematic review of human studies

et al. 2022

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Background:The environment plays a key role in male infertility, changing the incidence in various populations, and pesticides are one of the most studied hazards.The use of the latter has never decreased, jeopardizing the safety of workers and the general population.Objective: Our purpose was to summarize the results of studies discussing the association between pesticides and male fertility. Methods: A comprehensive literature search was performed through MEDLINE via PubMed, Scopus, and Web of Science. Only human studies were considered. Semen parameters and DNA integrity were considered to evaluate the effect of pesticides on men.Results: A total of 64 studies that investigated their impact in terms of semen parameters (51 studies) and chromatin and DNA integrity (25 studies) were included. The most frequently affected parameters were total sperm count, sperm motility, and sperm morphology, although a reduction in ejaculate volume and concentration occur in several cases. A tangible worsening of semen quality was associated with organochlorines and organophosphates. Furthermore, pesticide exposure, especially pyrethroids, was related to a higher DNA fragmentation index and chromosome aneuploidy in most articles. Conclusion:The epidemiological evidence supports the association between pesticides and male fertility for workers and the exposed population in terms of semen quality, DNA fragmentation, and chromosome aneuploidy.

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Methyl parathion causes genetic damage in sperm and disrupts the permeability of the blood-testis barrier by an oxidant mechanism in mice

Cited by 33 publications

References 50 publications

Pesticides and Male Fertility: A Dangerous Crosstalk

Pesticides and Male Fertility: A Dangerous Crosstalk

Do environmental and occupational exposure to pyrethroids and organophosphates affect human semen parameters? Results of a systematic review and meta‐analysis

The environmental and occupational influence of pesticides on male fertility: A systematic review of human studies

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