Methyl jasmonate attenuated lipopolysaccharide-induced depressive-like behaviour in mice

Adebesin, Adaeze; Adeoluwa, Olusegun; Eduviere, Anthony T.; Umukoro, Solomon

doi:10.1016/j.jpsychires.2017.06.007

Cited by 23 publications

(25 citation statements)

References 39 publications

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“…According to the observations of animal signs and symptoms, T11 pre-treatment could effectively alleviate the special symptoms in LPS-induced mice, including depression (Adebesin et al, 2017; Li M. et al, 2017), curled up, eye secretions increase ( Supplementary Figure S3 ) and severe diarrhea ( Figure 6B ). The body weight, food intake and water intake were also recorded every day.…”

Section: Resultsmentioning

confidence: 97%

Triptriolide Alleviates Lipopolysaccharide-Induced Liver Injury by Nrf2 and NF-κB Signaling Pathways

et al. 2018

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Nrf2 (Nuclear Factor Erythroid 2 Related Factor 2) transcription factor not only regulates oxidative stress response, but also represses inflammation by regulating cytokines production and cross-talking with NF-κB signaling pathways. Nrf2 plays an essential role in liver injury induced by oxidative stress and inflammation. Triptriolide (T11) is a minor component of Tripterygium wilfordii Hook F. (TwHF), which can be obtained by hydrolysis reaction of triptolide (T9). The major purpose of this study is to clarify the regulating effects of T11 on oxidative stress and inflammation in vivo and in vitro. LPS-stimulated RAW 264.7 cells were used to verify the regulating effects of T11 on oxidative stress (ROS and Nrf2 signaling pathway) and inflammatory cytokines production (TNF-α, IL-6 and IL-1β). The antioxidant responsive element (ARE) luciferase assay was employed to evaluate Nrf2 activation effect of T11 in HEK-293T cells. Lipopolysaccharides (LPS) induced acute liver injury (ALI) in BALB/c mice were used to study the protective effects (ALT, AST, MDA, SOD, histopathology and neutrophils/macrophages filtration) and the underlying protection mechanisms of ALI amelioration (Nrf2 and NF-κB signaling pathway) of T11. Firstly, the results showed that T11 can not only effectively decrease the productions of inflammatory cytokines (TNF-α, IL-6 and IL-1β), ROS and NO in LPS-stimulated RAW 264.7 cells, but also further significantly increase the activity of Nrf2 in HEK-293T cells. Secondly, the results suggested that T11 could dramatically decrease the oxidative stress responses (SOD and MDA) and inflammation (histopathology, neutrophils/macrophages filtration, TNF-α, IL-6 and IL-1β production) in LPS-induced ALI in BALB/c mice. Finally, the results implied that T11 could dramatically increase Nrf2 protein expression and decrease p-TAK1, p-IκBα and NF-κB protein expression both in vivo and in vitro. In conclusion, our findings indicated that T11 could alleviate LPS induced oxidative stress and inflammation by regulating Nrf2 and NF-κB signaling pathways in vitro and in vivo, which offers a novel insights for the application of TwHF in clinical.

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Section: Resultsmentioning

confidence: 97%

Triptriolide Alleviates Lipopolysaccharide-Induced Liver Injury by Nrf2 and NF-κB Signaling Pathways

et al. 2018

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“…Moreover, MJ demonstrated adaptogenic, antiamnesic, and antipsychotic activities in rodents [Eduviere et al, ; Umukoro et al, ; Annafi et al, ] and exhibited antidepressant‐like activity in mice subjected to acute stress models of forced swimming (FST) and tail suspension (TST) tests. It also attenuated depressive‐like symptoms induced by lipopolysaccharide in mice [Umukoro et al, ; Adebesin et al, ]. However, no studies have been carried out to assess the effect of MJ on UCMS‐induced depression‐like behavior, which reflects the clinical depressive illnesses seen in humans [Willner et al, ; Farooq, ; Chakravarty et al, ; Zhu et al, ].…”

Section: Introductionmentioning

confidence: 99%

Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress‐Induced Behavioral and Biochemical Alterations in Mouse Brain

Adebesin

Ajayi

Olonode

et al. 2017

Drug Development Research

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Preclinical Research The effects of methyl jasmonate (MJ; 5, 10, 20 mg/kg, i.p), a natural product widely used for the relief of stress, depression, and exhaustion on unpredictable chronic mild stress (UCMS)-induced depression-like behaviors in mice was assessed and compared to those of imipramine (IMP; 10 mg/kg, i.p). MJ and IMP were given 30 min before exposure to UCMS with the procedure repeated daily for 2 weeks; 24 h after the stress session, the tail suspension test (TST) and sucrose preference test were assessed. MJ decreased immobility time in the TST and reversed impaired intake of sucrose relative to the stressed control suggesting antidepressant-like activity. MJ also reduced UCMS-induced increases in corticosterone and MDA (malondialdehyde) levels and attenuated UCMS-induced decreases in GSH and TNF-α levels and SOD activity. These findings suggest that MJ attenuated UCMS-induced depressive-like behaviors through decreased levels of corticosterone and decreasing oxidative stress and neuroinflammation in mouse brain.Drug Dev Res 78 : 381-389, 2017. © 2017 Wiley Periodicals, Inc.

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“…Tail suspension test was carried out on mice according to a procedure outlined by Adebesin, Adeoluwa, Eduviere, and Umukoro (). Animals ( n = 8) were treated with vehicle and with AA at doses of 10, 25, and 50 mg/kg.…”

Section: Methodsmentioning

confidence: 99%

“…Animals ( n = 8) were treated with vehicle and with AA at doses of 10, 25, and 50 mg/kg. After 30 min of AA administration, animals were subjected to this test where the total duration of immobility induced by tail suspension was measured (Adebesin et al, ). Mice were suspended 50 cm above the floor by an adhesive tape placed about 1 cm from the tip of the tail.…”

Section: Methodsmentioning

confidence: 99%

Antidepressant‐like effect of anacardic acid in mice via the L‐arginine–nitric oxide–serotonergic system

Júnior

Tchekalarova

Machado

et al. 2019

Phytotherapy Research

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Depression, a multifactorial neuronal disorder with high morbidity/mortality, is associated with psychological, psychosocial, hereditary, and environmental etiologies, where reactive species exert pathophysiological functions. Anacardic acid (AA), a natural compound obtained from cashew nut liquid, has several pharmacological activities, including antioxidant and anticonvulsant. The aim of the present study was to evaluate the antidepressant-like effect of AA and the involvement of serotonergic, noradrenergic, and L-arginine-nitric oxide (NO) in tail suspension and forced swim tests and, more so, to investigate its antioxidant effect in Saccharomyces cerevisiae and in male Swiss mice (n = 8). In order to identify the antidepressant mechanisms, AA (10, 25, or 50 mg/kg, p.o.) was given 30 min before clonidine (2-adrenergic receptor agonist), L-arginine (NO precursor), propranolol (β-adrenergic receptor antagonist), and several other agonists or antagonists used. On the other hand, clonidine, noradrenoreceptor, noradrenaline, and L-arginine were used to identify the antidepressant mechanisms. Results suggest that AA exerts antidepressant-like activity, especially at higher doses, possibly by inhibiting serotonin and 5HT-1A reuptake receptors and by inhibiting NO synthetase and guanylyl cyclase enzymes.

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Methyl jasmonate attenuated lipopolysaccharide-induced depressive-like behaviour in mice

Cited by 23 publications

References 39 publications

Triptriolide Alleviates Lipopolysaccharide-Induced Liver Injury by Nrf2 and NF-κB Signaling Pathways

Triptriolide Alleviates Lipopolysaccharide-Induced Liver Injury by Nrf2 and NF-κB Signaling Pathways

Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress‐Induced Behavioral and Biochemical Alterations in Mouse Brain

Antidepressant‐like effect of anacardic acid in mice via the L‐arginine–nitric oxide–serotonergic system

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