Methyl esterification of 15‐hydroperoxyabietic acid does not affect the patch‐test result in colophonium allergic patients

Karlberg, Ann‐Therése; Bråred-Christensson, Johanna; Börje, Anna; Harambasic, Elma; Matura, Mihály

doi:10.1111/j.1600-0536.2006.01037.x

Cited by 9 publications

(2 citation statements)

References 8 publications

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“…A variety of other oxidation products from abietic acid and dehydroabietic acid (the other major resin acid in colophony) were isolated and identified, some of which were shown to be sensitizers in guinea pig studies . Clinical investigations have shown that patch testing with 29 detects about 50% of the patients with contact allergy to colophony , .…”

Section: Activation Of Nonsensitizing Compounds By Air Oxidationmentioning

confidence: 99%

Allergic Contact Dermatitis––Formation, Structural Requirements, and Reactivity of Skin Sensitizers

Karlberg

Bergström

Börje

et al. 2007

Chem. Res. Toxicol.

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248

223

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Contact allergy is caused by a wide range of chemicals after skin contact. Its clinical manifestation, allergic contact dermatitis (ACD), is developed upon repeated contact with the allergen. This perspective focuses on two areas that have yielded new useful information during the last 20 years: (i) structure-activity relationship (SAR) studies of contact allergy based on the concept of hapten-protein binding and (ii) mechanistic investigations regarding activation of nonsensitizing compounds to contact allergens by air oxidation or skin metabolism. The second area is more thoroughly reviewed since the full picture has previously not been published. Prediction of the sensitizing capacity of a chemical is important to avoid outbreaks of ACD in the population. Much research has been devoted to the development of in vitro and in silico predictive testing methods. Today, no method exists that is sensitive enough to detect weak allergens and that is robust enough to be used for routine screening. To cause sensitization, a chemical must bind to macromolecules (proteins) in the skin. Expert systems containing information about the relationship between the chemical structure and the ability of chemicals to haptenate proteins are available. However, few designed SAR studies based on mechanistic investigations of prohaptens have been published. Many compounds are not allergenic themselves but are activated in the skin (e.g., metabolically) or before skin contact (e.g., via air oxidation) to form skin sensitizers. Thus, more basic research is needed on the chemical reactions involved in the antigen formation and the immunological mechanisms. The clinical importance of air oxidation to activate nonallergenic compounds has been demonstrated. Oxidized fragrance terpenes, in contrast to the pure terpenes, gave positive patch test reactions in consecutive dermatitis patients as frequently as the most common standard allergens. This shows the importance of using compounds to which people are exposed when screening for ACD in dermatology clinics.

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Section: Activation Of Nonsensitizing Compounds By Air Oxidationmentioning

confidence: 99%

Allergic Contact Dermatitis––Formation, Structural Requirements, and Reactivity of Skin Sensitizers

Karlberg

Bergström

Börje

et al. 2007

Chem. Res. Toxicol.

Self Cite

248

223

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“…Colophonium (rosin) is a natural resin derived from pine. It contains numerous chemical compounds, mostly abietic acid and its derivatives …”

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confidence: 99%

Allergic contact dermatitis to abietic acid derivatives in an over‐the‐counter hydrocolloid dressing

et al. 2020

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Allergic Contact Dermatitis

Wilkinson,

Orton

2016

Rook's Textbook of Dermatology, Ninth Edition

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Allergic contact dermatitis is the classic delayed hypersensitivity reaction, developing in two phases – sensitization and elicitation. It can have profound effects on affected individuals and may result in sickness, absence from work and increased health expense. Its diagnosis requires consideration of many factors including the patient's history and a physical examination; knowledge of the skin's reaction to various chemicals is also desirable. Above all, it requires a high degree of suspicion on the part of the clinician and tenacity, skill and experience in the investigator. The diagnosis can only be confirmed by interpreting patch test results and the technique in itself has many pitfalls for the unwary. Any sensitization identified needs to be put into the context of a past or present dermatitis, and explanations for allergen avoidance or substitution need to be provided for the patient.

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Methyl esterification of 15‐hydroperoxyabietic acid does not affect the patch‐test result in colophonium allergic patients

Cited by 9 publications

References 8 publications

Allergic Contact Dermatitis––Formation, Structural Requirements, and Reactivity of Skin Sensitizers

Allergic Contact Dermatitis––Formation, Structural Requirements, and Reactivity of Skin Sensitizers

Allergic contact dermatitis to abietic acid derivatives in an over‐the‐counter hydrocolloid dressing

Allergic Contact Dermatitis

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