Methyl aminolevulinate photodynamic therapy for actinic keratosis does not affect peripheral regulatory T‐cell level or function

Reginato, Eleonora; Gruber‐Wackernagel, Alexandra; Wolf, Peter

doi:10.1111/phpp.12178

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…24 Moreover, some researchers believe that patients with CD4 count lower than 200 cells/μl have a higher CA recurrence rate after surgical treatment, and cART treatment can help reduce postoperative recurrence. 25 These results suggest that it is possible to significantly reduce the CA recurrence rate after ALA-PDT if 32 This may indicate that ALA-PDT treatment does not affect peripheral blood CD4 cells. However, the effect of ALA-PDT treatment on peripheral blood T cells of CA has not been reported, and should be analyzed in future research.…”

Section: Correlation Between Cd4 Cell Count and Recurrence Rate After...mentioning

confidence: 84%

“…In conclusion, ALA‐PDT can counter CA through activating local immunity, and CD4 cells play a major role in this process. Moreover, some studies have shown that photodynamic therapy does not affect peripheral blood T‐cell level or function in the treatment of multiple actinic keratosis 32 . This may indicate that ALA‐PDT treatment does not affect peripheral blood CD4 cells.…”

Section: Discussionmentioning

confidence: 99%

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Peripheral blood CD4⁺ T cell count predicts recurrence of condyloma acuminatum after photodynamic therapy in HIV‐positive patients

Zhou

Shi

et al. 2022

Photoderm Photoimm Photomed

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Background Few studies have reported postoperative relapse of condyloma acuminatum (CA) after 5‐aminolevulinic acid photodynamic therapy (ALA‐PDT) in human immunodeficiency virus (HIV) positive patients. Methods The clinical data of HIV‐positive CA patients treated with ALA‐PDT from October 2018 to December 2019 were analyzed retrospectively. Univariate and multivariate Cox regression was used to analyze the variables related to postoperative recurrence. Pearson correlation test was employed to analyze the correlation between CD4+ T cell count and postoperative recurrence rate. Kaplan–Meier method was used to compare the CA recurrence after ALA‐PDT in low CD4 group and high CD4 group. Results A total of 38 HIV‐positive patients with CA were included in the study. Among them, 26 patients experienced CA recurrence within 6 months, and the recurrence rate was 68.4%. CD4+ T cell count was 187.0 (79.0–596.0) cells/μl in relapsed patients and 406.0 (89.0–612.0) cells/μl in non‐relapsed patients, showing a statistically significant difference (p = .005). Pearson correlation coefficient analysis revealed a negative correlation between CD4+ T cell count and postoperative recurrence rate (p = .005, r = −.443). Univariate regression analysis showed that CD4+ T cell count was correlated with postoperative recurrence, hazard ratio (HR) was 0.99 [95% Confidence interval (CI) = 0.99–1.0, p = .012]. Multivariate Cox regression analysis showed that with the low CD4+ T cell count as the reference, the high CD4+ T cell count was negatively correlated with postoperative recurrence (HR = 0.09, 95% CI 0.01–0.87, p = .038). Conclusions Peripheral blood CD4+ T cell count can predict the CA recurrence rate after ALA‐PDT in HIV‐positive patients.

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Section: Correlation Between Cd4 Cell Count and Recurrence Rate After...mentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Peripheral blood CD4⁺ T cell count predicts recurrence of condyloma acuminatum after photodynamic therapy in HIV‐positive patients

Zhou

Shi

et al. 2022

Photoderm Photoimm Photomed

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“…The authors found that MAL-PDT did not influence significantly the number and even the function of Tregs in patients with multiple AK. 70 Other human studies analyzing the composition of T cells in AKs or the influence of PDT on T cells in human AK samples are not yet available. It would be important to evaluate these changes to gain real information about the mechanism of action of PDT on AKs, and to possibly explain the occasionally observed therapeutic failure.…”

Section: Photosensitizers and Dampsmentioning

confidence: 99%

Immunological effects of photodynamic therapy in the treatment of actinic keratosis and squamous cell carcinoma

Gellén

Fidrus

Péter

et al. 2018

Photodiagnosis and Photodynamic Therapy

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The use of photodynamic therapy is extensive, due to its antitumoral, antibacterial and photorejuvenation effects. It destroys tumor via direct cell destruction and indirectly via vascular shutdown, induction of acute local inflammatory response and activation of the immune system. Both innate and adaptive immune cells are involved in the immunological effects of photodynamic therapy. In addition to UV-induced DNA damage, inflammation and immunosuppression are also essential elements in the pathogenesis of actinic keratosis. Both immunosuppression induced by UV and defective immune response to dysplastic keratinocytes may be the target of photodynamic therapy to eliminate actinic keratosis. These elements are discussed in the present review, highlighting the possible mechanism of photodynamic therapy to effectively treat actinic keratosis.

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Application of photodynamic therapy in immune-related diseases

Yang

Lei

Pan

et al. 2021

Photodiagnosis and Photodynamic Therapy

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Methyl aminolevulinate photodynamic therapy for actinic keratosis does not affect peripheral regulatory T‐cell level or function

Cited by 3 publications

References 10 publications

Peripheral blood CD4⁺ T cell count predicts recurrence of condyloma acuminatum after photodynamic therapy in HIV‐positive patients

Peripheral blood CD4⁺ T cell count predicts recurrence of condyloma acuminatum after photodynamic therapy in HIV‐positive patients

Immunological effects of photodynamic therapy in the treatment of actinic keratosis and squamous cell carcinoma

Application of photodynamic therapy in immune-related diseases

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Methyl aminolevulinate photodynamic therapy for actinic keratosis does not affect peripheral regulatory T‐cell level or function

Cited by 3 publications

References 10 publications

Peripheral blood CD4+ T cell count predicts recurrence of condyloma acuminatum after photodynamic therapy in HIV‐positive patients

Peripheral blood CD4+ T cell count predicts recurrence of condyloma acuminatum after photodynamic therapy in HIV‐positive patients

Immunological effects of photodynamic therapy in the treatment of actinic keratosis and squamous cell carcinoma

Application of photodynamic therapy in immune-related diseases

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Product

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Peripheral blood CD4⁺ T cell count predicts recurrence of condyloma acuminatum after photodynamic therapy in HIV‐positive patients

Peripheral blood CD4⁺ T cell count predicts recurrence of condyloma acuminatum after photodynamic therapy in HIV‐positive patients