Methuosis: Drinking to Death

Aqil, Madeeha

doi:10.1002/9781119432463.ch26

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…AS1411 is internalized after binding to the cell surface via the nucleolin receptor and may inhibit nucleolin binding to mRNA-encoding anti-apoptotic B-cell lymphoma 2 (BCL2), thereby leading to mRNA destabilization and nucleolytic degradation, which, in turn, may result in a reduction in BCL2 expression at protein level, and the induction of apoptosis. However, this effect is presumed and, more research is needed to confirm it, while one study found that cell death caused by a given aptamer occurs via methuosis, a non-apoptotic pathway of cell death, which is also a poorly understood issue [ 142 , 143 , 144 ]. However, the effectiveness of aptamer as a targeting ligand is undeniable, which has been proven in research [ 144 ].…”

Section: Recent Advancements In Cancer Gene Therapy Studies Using mentioning

confidence: 99%

Recent Advances in Preclinical Research Using PAMAM Dendrimers for Cancer Gene Therapy

Tarach

Janaszewska

2021

IJMS

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Carriers of genetic material are divided into vectors of viral and non-viral origin. Viral carriers are already successfully used in experimental gene therapies, but despite advantages such as their high transfection efficiency and the wide knowledge of their practical potential, the remaining disadvantages, namely, their low capacity and complex manufacturing process, based on biological systems, are major limitations prior to their broad implementation in the clinical setting. The application of non-viral carriers in gene therapy is one of the available approaches. Poly(amidoamine) (PAMAM) dendrimers are repetitively branched, three-dimensional molecules, made of amide and amine subunits, possessing unique physiochemical properties. Surface and internal modifications improve their physicochemical properties, enabling the increase in cellular specificity and transfection efficiency and a reduction in cytotoxicity toward healthy cells. During the last 10 years of research on PAMAM dendrimers, three modification strategies have commonly been used: (1) surface modification with functional groups; (2) hybrid vector formation; (3) creation of supramolecular self-assemblies. This review describes and summarizes recent studies exploring the development of PAMAM dendrimers in anticancer gene therapies, evaluating the advantages and disadvantages of the modification approaches and the nanomedicine regulatory issues preventing their translation into the clinical setting, and highlighting important areas for further development and possible steps that seem promising in terms of development of PAMAM as a carrier of genetic material.

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Section: Recent Advancements In Cancer Gene Therapy Studies Using mentioning

confidence: 99%

Recent Advances in Preclinical Research Using PAMAM Dendrimers for Cancer Gene Therapy

Tarach

Janaszewska

2021

IJMS

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“…The Medicinal plants consider ahigh economical and medicinal value and they occupy ahigh status in this time in aplant production because of their important in averious life fields [1] and they are amain source for aplant medicinal drugs and araw matter to produce important chemical materials [2]besides that they have no side effects, for their use compared with thos drugs produced chemically as well as their capacity to inhibit amicrobs [3]. A cress plant (Lepidium sativum L.) belong to Asteraceae family, it has an important and medicinal benefits and high food important materials it contains many Vitamins (A,B 1 , B 2 , B 3 , B 5 , C, E, K, H) and it contains 32 k.callary, 55gm charbohydrats, 4.4 suger, 2.6 broteins, and elements Cu, Fe, Mg, Mn, P, K, Zn and I. for this importance there are different ways to develop its production like aplant growth regulators use as GA 3 and micro Nutrients as Fe and Mn GA 3 organic compound has a direct influence on growth [4] it makes to increase a cell devission and cell enlargement and other vegetative growth qualities.…”

Section: Introductionmentioning

confidence: 99%

Effect of spraying of GA3 and Some Micronutrients on the growth and Mineral content of Cress plant (Lepidium sativum L.)

AL-Tememe¹,

Hachim²

2020

Tikrit J. Pure Sci.

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This study is conducted in aspicial farm in Adujail city\Salahaddin Governorate at the season 2015 on the cress plant. Afactorial experiment has conducted with two factors, the first is spraying with GA3 (G0 without spraying, G1 spraying with 50 mg.L-1, G2 spraying with 100 mg.L-1of GA3).the second factor is spraying with Micro Nutrients (T0 without spraying, T1spraying with 50 mg.L-1 of Fe,T2 spraying with 50 mg.L-1 of Mn, T3 spraying with amixture of 50+50 mg.L-1from Fe and Mn). The experiment is designed with (RCBD), the treatments were replicated 4 times and Duncuns Multiple Range Test at the probability 5% is used and the results are as fellowed: GA3 spraying causes asignificant increase in all Vegetative growth characters compared with the others which are not sprayed and also the Macro Nutrients concentration. Micro Nutrients sprayes on the Cress plants also causes asignificant increase in most Vegetative characters and Macro and Micro Nutrients content, specially the treatment of Fe and Mn mixture. Interaction between GA3 and Micronutrient is significant in all the treatment specially the treatment (100 mg.L-1 of GA3 + amixture of 50+50 mg.L-1 of Fe + Mn ) which give ahighest values of Vegetative growth and Macro and Micro Nutrients content .

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Spiropachysine A suppresses hepatocellular carcinoma proliferation by inducing methuosis in vitro and in vivo

et al. 2022

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Methuosis: Drinking to Death

Cited by 3 publications

References 32 publications

Recent Advances in Preclinical Research Using PAMAM Dendrimers for Cancer Gene Therapy

Recent Advances in Preclinical Research Using PAMAM Dendrimers for Cancer Gene Therapy

Effect of spraying of GA3 and Some Micronutrients on the growth and Mineral content of Cress plant (Lepidium sativum L.)

Spiropachysine A suppresses hepatocellular carcinoma proliferation by inducing methuosis in vitro and in vivo

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