Methoxido‐Bridged Lacunary Heterocubane Oxidovanadium(IV) Cluster with Azo Ligands: Synthesis, X‐ray Structure, Magnetic Properties, and Antiproliferative Activity

Abstract

The new μ 3 -methoxido bridged trinuclear vanadium(IV) complexes [V IV 3 O 3 (μ 3 -OMe)(μ 2 -OMe) 3 (L 1,2 ) 2 ] (1 and 2) have been synthesized using the azo ligands 1-(2-(thiazol-2yl)diazenyl)naphthalene-2-ol (HL 1 ) and 2-(2-(thiazol-2yl)diazenyl)-4-methylphenol (HL 2 ). X-ray crystallography revealed a trinuclear structure with a lacunary heterocubane {(VO) 3 (μ 3 -OMe)(μ 2 -OMe) 3 } 2 + core unit for complex 1, which contains a central μ 3 -methoxido bridge. All three vanadium centers are in a slightly distorted octahedral coordination environment. Magnetic and theoretical studies reveal an antiferromagnetic coupling between the three vanadium(IV) centers within the triangular arrangement in 1. The complexes were also screened for in vitro cytotoxicity study against HeLa and HT-29 cancer cell lines. The results indicated that both the complexes are cytotoxic but possess varying specificity towards different cell types.

Mitochondria-Targeted Luminescent Organotin(IV) Complexes: Synthesis, Photophysical Characterization, and Live Cell Imaging

“…On the trend of our ongoing research into the development of new transition-metal complexes with anticancer potential, − here we have diverted our focus on main-group metal complexes to discuss their biological action, in particular as cellular markers (depending upon the cytotoxicity potential), and report a set of highly fluorescent organotin­(IV) compounds ( 1–5 ) coordinated with Schiff base ligands. While designing the complexes, various electron donor and withdrawing groups were introduced into the ligands to analyze their effect on bioimaging applications.…”

LVVO-Ethyl Maltol-Based Metallodrugs (L2– = Tridentate ONO Ligands): Hydrophobicity, Hydrolytic Stability, and Cytotoxicity via ROS-Mediated Apoptosis

“…With knowledge gained from the above discussions and as part of our ongoing synthetic and pharmacological research on vanadium­(IV/V) complexes, − ,− in this report, the synthesis of a series of mixed-ligand oxidovanadium­(V) [V V OL 1–4 (ema)] ( 1 – 4 ) complexes with two aroylhydrazones (H 2 L 1,2 ) and two Schiff bases (H 2 L 3,4 ) as the main ligands involving ethyl maltol (Hema) as a coligand is described. Our mixed-ligand complexes were designed so that we could see their overall role in interacting with biomolecules after the removal of the coligand, if that was the case.…”

Fluorescent Diorganotin(IV) Complexes as Anticancer Agents: Study of Cytotoxicity, Cellular Localization, and Mechanism of Cell Death

“…Continuing our ongoing research on developing new transition-metal-based anticancer drugs; − here, our attention has been turned toward main-group metal complexes, especially organotin systems, to investigate their anticancer potential. In a recent article, we emphasized the bioimaging properties of organotin­(IV) complexes, which showed low cytotoxicity .…”