Methotrexate-related lymphoproliferative disorders in the liver: Case presentation and mini-review

Methotrexate-associated Lymphoproliferative Disorder in the Liver Resembling Hepatocellular Carcinoma Treated with Transarterial Chemoembolization

“…Thus far, 16 cases with MTX-LPD in the liver have been reported ( 10 , 11 , 23 ), and the duration of MTX has ranged from 24 to 120 months. Therefore, the MTX duration of 17 years in the present case is the longest yet recorded.…”

“…Therefore, the MTX duration of 17 years in the present case is the longest yet recorded. Regarding imaging findings, it was reported that liver tumors of MTX-LPD appeared as low-density areas on plain CT images and that most tumors were hypovascular on contrast-enhanced CT, although some showed mild ring enhancement ( 10 ). Because no typical imaging features of hepatic lymphoma have been reported, it is difficult to distinguish hepatic lymphoma from HCC or metastatic tumors based on imaging findings alone ( 11 ).…”

“…MTX-associated LPD (MTX-LPD) is found not only in lymph nodes but also several other organs such as the intestinal tract, skin, and lung ( 8 ), but its involvement in the liver is very rare, and the etiology and clinical outcome are largely unknown ( 9 ). In addition, the typical imaging features of MTX-LPD in the liver have not been defined, and its diagnosis by imaging tests is considered difficult ( 10 , 11 ).…”