Methotrexate loaded chitosan nanoparticles: Preparation, radiolabeling and in vitro evaluation for breast cancer diagnosis

Radiolabeling and cell incorporation studies of gemcitabine HCl microspheres on bladder cancer and papilloma cell line

“…Ekinci et al only used the incorporation percentages of the labeled nanoparticles for quality control studies. The authors conclude the incorporated activity on particular systems is giving more reliable and accurate information about labeling yield and stability of the labeled compound [28]. In our study, the obtained results support this interpretation.…”

“…Ekinci et al investigated the newly developed radioactive nanoparticulate drug delivery system breast cancer cell line affinity by using cell culture studies. According to performed study the authors were conclude the newly developed drug can be used for breast cancer since their high Target/Non Target ratio on cell lines [28].…”

Estimating Binding Capability of Radiopharmaceuticals by Cell Culture Studies

“…Their results demonstrated that the incorporation of 99m Tc-MTX loaded NPs in breast cancer cells was found about 2-times higher than normal cells. The authors conclude that, due to the high incorporation for breast cancer cell line, newly developed formulation may be used for breast cancer diagnosis in nuclear medicine center [26].…”

“…Many researchers were performed studies to investigate new radiopharmaceuticals for folate receptor positive tumor imaging or therapy [20][21][22][23][24][25][26]. While some of those performed in vivo imaging studies with tumor model created mice, others investigate receptor positive tumor cell affinity by cell culture studies.…”

“…Also Ekinci et al developed radiolabeled MTX loaded nanoparticulate systems for breast cancer imaging [26]. The researchers evaluated the binding affinity of the newly developed formulation to cancer cells by cell culture incorporation studies.…”