Methotrexate Intolerance in Juvenile Idiopathic Arthritis: Definition, Risks, and Management
Camilla Wibrand,
Nini Kyvsgaard,
Troels Herlin
et al.
Abstract:Juvenile idiopathic arthritis is the most common rheumatic disorder in childhood and adolescence posing a significant threat of short-term and long-term disability if left untreated. Methotrexate is a folic acid analog with various immunomodulatory properties. It has demonstrated significant efficacy for the treatment of juvenile idiopathic arthritis, often considered the preferred first-line disease-modifying anti-rheumatic drug given as monotherapy or in combination with biological drugs. Despite this, there… Show more
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