Methotrexate-Induced Nephrotoxicity in Rats: Protective Effect of Mistletoe (&lt;b&gt;&lt;i&gt;Viscum album&lt;/i&gt;&lt;/b&gt; L.) Extract

Çetin, Esin Sakallı; Tetiker, Hasan; Çelik, Özgür; Yılmaz, Nigar; Çiğerci, İbrahim Hakkı

doi:10.1159/000468984

Cited by 8 publications

(5 citation statements)

References 42 publications

(69 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore plasma MTX concentration monitoring, adequate hydration, urine alkalization and using glucarpidase are recommended during treatment to facilitate renal elimination. 8 Mechanistically, the link between OS and other signaling pathways is well understood. It has been reported that OS can play a role in the development of a variety of diseases by activating the inflammatory response, inducing apoptosis and cell death; furthermore, OS decreases the expression of NRF-2, with the consequent down-regulation of antioxidant genes.…”

Section: Discussionmentioning

confidence: 99%

“…most notably renal and liver toxicity as well as duodenal damage, 7 and bone marrow toxicity. 8 Methotrexate-induced renal toxicity has been related to several different damage pathways, comprising oxidative stress and inflammatory reactions, mitochondrial dysfunction, and lastly, apoptosis. 9 Vitamin B6, a member of the water-soluble vitamin family, is made up of three related compounds: pyridoxine, pyridoxal, and pyridoxamine; 10 as shown in Figure 2 (structure 1).…”

Section: Research Articlementioning

confidence: 99%

See 1 more Smart Citation

Effects of Co-administration of Pyridoxine in Two Different Doses with Methotrexate-induced Nephrotoxicity in Rats

Zakri¹,

Al-Shawi²

2022

IJDDT

View full text Add to dashboard Cite

Nephrotoxicity is defined as rapid deterioration in kidney functions that arises from direct exposure to a drug or its metabolite. Methotrexate is an anti-metabolite used in low doses for autoimmune and inflammatory disorders and high doses for different malignancies. Pyridoxine is the usual form of vitamin B6 included in pharmaceutical products. This study is designed to examine the effect of pyridoxine in two different doses, each co-administered with methotrexate at 20 mg/kg made renal toxicity in rats through the involvement of Nrf2/HO-1 molecular mechanism in this respect. The animals used in this research were allocated to four distinct groups (each group with 10 rats) of both sexes; as control, MTX, pyridoxine 33 mg/kg and MTX, Pyridoxine 100 mg/kg, and MTX. Serum creatinine, neutrophil gelatinase-associated lipocalin (NGAL), and NrF2/HO-1 signaling pathway were determined. Administration of Pyridoxine (33 mg/kg intraperitoneally) in combination with MTX showed no significant differences (p >0.05) as compared to the MTX group. At the same time, administration of pyridoxine (100 mg/kg intraperitoneally) in combination with methotrexate showed a significant reduction in serum activities of both neutrophil gelatinase associated lipocalin (NGAL) and creatinine (p is less than 0.05) and significant upregulation in Nrf2/HO-1 signaling pathway each compared to corresponding levels in MTX-only group. In conclusion, this study demonstrated that when pyridoxine (100 mg/kg IP) was administered in combination with methotrexate, the renal toxicity was reduced as a result.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Research Articlementioning

confidence: 99%

Effects of Co-administration of Pyridoxine in Two Different Doses with Methotrexate-induced Nephrotoxicity in Rats

Zakri¹,

Al-Shawi²

2022

IJDDT

View full text Add to dashboard Cite

show abstract

“…Helixor M, extract from Viscum album L. growing on apple tree, showed activity against methotrexate (MTX)-induced acute oxidative stress and nephrotoxicity in rats. The mechanism included antioxidant and anti-inflammatory properties, as evident from significant increase in the activities of the antioxidative enzymes, superoxide dismutase (SOD) and glutathione peroxidise (GSH-Px) (Sakalli Çetin et al 2017). Oleanolic acid isolated from Viscum articulatum Burm.…”

Section: Nephroprotective and Antidiuretic Activitymentioning

confidence: 99%

Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action

2020

View full text Add to dashboard Cite

Boiss. Mistletoe is a semi-parasitic evergreen shrub, which means it depends on having water and some nutrients supplied from another plant (host tree) while it produces carbohydrates in a process of photosynthesis. Viscum species inhabit many types of wooded habitats and parasitize both deciduous and coniferous trees (Bussing 2000). For clinical applications, the most popular species are mistletoe parasitizing fir, maple, almond, birch, hawthorn, ash, apple, pine, poplar, oak, willow, lime and elm (Kienle et al. 2011). Viscum species have been used in the traditional medicine of Europe for centuries. Hippocrates used mistletoe to treat diseases of the spleen and complaints associated with menstruation, while Pliny the Elder used it to treat epilepsy, infertility and ulcers. In the Middle Ages, Paracelsus recommended mistletoe as a treatment for epilepsy. Hildegard von Bingen described mistletoe as a treatment for diseases of the spleen and liver. Mistletoe was also applied for deworming children, to treat labour pains, gout, affections of the lungs and liver, leprosy, mumps, fractures and hepatitis. During the eighteenth century, mistletoe was applied for "weakness of the heart" and oedema (Bussing 2000). By the end of the nineteenth century, mistletoe was rejected by scientists as a folklore remedy. The scientific interest on mistletoe was awakened in the twentieth century, as Gaultier investigated the effect of oral or subcutaneous Abstract Mistletoe has been used as treatment of many diseases in traditional and folk medicine. To date, anticancer, immunomodulatory, cardiac, antidiabetic, hepatoprotective, neuropharmacological, antibacterial and antifungal properties of mistletoe extracts have been studied the most. In this review, we summarized in vitro and in vivo studies on the pharmacological activity of Viscum species. Furthermore, we proposed the possible mechanisms of action of this herb, which might include many signalling pathways. Mistletoe could regulate either similar or different targets in various pathways that act on membrane receptors, enzymes, ion channels, transporter proteins and transcriptional targets. Still, pharmacological activities of mistletoe have been investigated mainly for crude extracts. It is a new field for scientists to determined which chemical compounds are responsible for the individual biological activities of mistletoe and how these activities are achieved. As a result, mistletoe might become a source of new complementary therapies supporting the treatment of many diseases.

show abstract

“…Aber warum ist das so? Die dritte Publikation in dieser Ausgabe der CMR zum Einsatz der Mistel beim Tier ist -anhand eines Laborversuchs mit Ratten -ein Beitrag zur Aufklärung der Wirkmechanismen der Nebenwirkungsreduktion einer durch den chemotherapeutischen Wirkstoff Methotrexat induzierten Nierenschädigung [14].…”

Section: Labortiereunclassified

Tiermedizinische Publikationen in Complementary Medicine Research

Walkenhorst¹

2017

Complement Med Res

View full text Add to dashboard Cite

Methotrexate-Induced Nephrotoxicity in Rats: Protective Effect of Mistletoe (<b><i>Viscum album</i></b> L.) Extract

Cited by 8 publications

References 42 publications

Effects of Co-administration of Pyridoxine in Two Different Doses with Methotrexate-induced Nephrotoxicity in Rats

Effects of Co-administration of Pyridoxine in Two Different Doses with Methotrexate-induced Nephrotoxicity in Rats

Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action

Tiermedizinische Publikationen in Complementary Medicine Research

Contact Info

Product

Resources

About