Methotrexate-Induced Hyperpigmentation Over Sun-Exposed Area

Panda, Prateek Kumar; Sharawat, Indar Kumar; Yadav, Ram Naresh

doi:10.1097/rhu.0000000000001428

Cited by 4 publications

(1 citation statement)

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“…adverse effects encompass gastrointestinal manifestations such as nausea, emesis, and diarrhoea (Wang et al, 2018); painful mouth sores making eating and drinking difficult (Chamorro-Petronacci et al, 2019); hair loss or thinning; can make patients more sensitive to sunlight, increasing the risk of sunburn and other skin irritation (Panda et al, 2021). Furthermore, MTX can harm the liver, especially at higher doses or with long-term use therefore, patients taking the drug need to have their blood levels and liver function monitored regularly (Conway and Carey, 2017c).…”

Section: Additionalmentioning

confidence: 99%

Potential Effects of Methotrexate on Health: A Review

Payal,

Girima

2023

Intern. J. Zool. Invest.

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Methotrexate (MTX) is a metabolite that functions as an antifolate, impeding DNA synthesis, repair, and cell replication. Its clinical uses include rheumatoid arthritis treatment and cancer treatments due to its anti-folate mechanism of action. This medication serves as the primary disease-modifying antirheumatic drug (DMARD) for individuals afflicted with dermatological, inflammatory, and autoimmune conditions. Methotrexate has a unique mode of action, both in terms of its usage as a chemotherapeutic drug and as an immunosuppressant, in the management of autoimmune disorders. It can be combined with anti-TNF (Tumour Necrosis Factor) drugs and used as an off-label treatment for graft-versus-host disease. However, there are limitations to its usage, such as increased toxicity problems and brief plasma life. Methotrexate can be used as a nano-drug to decrease administration frequency while maximizing pharmacological effects and minimizing systemic side effects. The utilization of nanodrugs has been found to be more efficacious in comparison to intra-articular or oral delivery methods. Additionally, it has been determined that the co-loading of MTX-SPIONs (Superparamagnetic iron oxide nanoparticles) in NLC (Nanostructured lipid carriers) has been found to be a viable carrier for the delivery of MTX. The present review focuses on potential effects of methotrexate on health.

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