Methotrexate-Associated Lymphoproliferative Disorder Presenting As Oral Ulcers in a Patient With Rheumatoid Arthritis

A Clinical, Pathological, and Genetic Characterization of Methotrexate-associated Lymphoproliferative Disorders

“…Of the 12 cases of MTX-LPD with mucocutaneous ulcer reported in the literature 7,10,11,12,13,14,15,16,17 all except 1 17 were EBV-positive and all 9 cases with available data showed complete remission without chemotherapy. Most of our patients with positive outcomes had been diagnosed with EBVMCU.…”

Reversible methotrexate-associated lymphoproliferative disorder (MTX-LPD) associated with Epstein–Barr virus in a patient with rheumatoid arthritis

“…MTX-LPD has been reported by several papers in the head and neck region but those in the tongue are rare [1,2,[7][8][9][10]. In this case, MTX-LPD arose as an ulcer of the tongue.…”

Linfoma B de localización facial

“…La afectación ganglionar constituye la manifestación más habitual de esta patología. La localización extranodal, especialmente a nivel de cabeza y cuello 4,5 , es también frecuente (sobre todo a nivel del anillo de Waldeyer) y se ha asociado en algunos casos a la terapia con metotrexato [6][7][8] . El diagnóstico del linfoma B extraganglionar se basa en el estudio histológico, observando en la biopsia infiltración difusa de células grandes de fenotipo B y que expresan en su membrana el antígeno CD20.…”