Methotrexate anchored carbon dots as theranostic probes: digitonin conjugation enhances cellular uptake and cytotoxicity

Krishna, Amresh; Radhakumary, C.; Priya, Shivam; Rekha, M.R.; Sreenivasan, K.

doi:10.1039/c6ra11660d

Cited by 10 publications

(7 citation statements)

References 27 publications

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“…Amine capped CDs were modified digitonin and then conjugated with MX. In vitro results indicates that enhanced cytotoxicity is observed in the CDMX [175]. Niclosamide (Nic) is an FDA-approved anthelminthic drug that has been acknowledged to demonstrate anti-neoplastic properties via the active inhibition of multiple pathways modulated in cancer stem cells [176].…”

Section: Fluorescent Cds Conjugated With Chemical Therapeutic Agentsmentioning

confidence: 99%

Recent advance of carbon dots in bio-related applications

Wang

Bao

et al. 2020

J. Phys. Mater.

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Carbon dots (CDs) is a kind of carbon nanoparticles with a plentiful of surface functional groups and tunable emission with different excitation wavelength. Broadly speaking, CDs include carbon nanodots, carbon quantum dots, graphene quantum dots, carbonized polymer dots. Due to the unique nature, they are explored for various applications in the bio-related fields such as bioimaging, sensor for ion and (bio)molecules, catalyst, LED and other fields. They are viewed as great alternative tracers to the current fluorescent biomarkers in personalized nanomedicine and surgery operation monitoring. In this review, we summarized the recent progress in the development of CDs, including improvement in fluorescence properties, two-photon fluorescence, and integration with other modalities as theragnostic agents. Specifically, we discussed the preparation of dual-modal imaging agents to improve the accuracy of diagnosis, the combination of imaging and targeting functionality for the effective accumulation of biomarkers, and the integration of imaging and therapeutic agents to effectively monitor the localization and concentration of therapeutic agents. Finally, the theragnostic agents composed of three functionalities (e.g. targeting, imaging, and therapy) were summarized to provide readers with future perspectives in this field.

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Section: Fluorescent Cds Conjugated With Chemical Therapeutic Agentsmentioning

confidence: 99%

Recent advance of carbon dots in bio-related applications

Wang

Bao

et al. 2020

J. Phys. Mater.

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“…25,26 Along with the development of sensitive ion studies, CDs can also be served as effective probes for dopamine, H 2 O 2 and theranostic. [27][28][29][30] Recently, Shi's group reported CDs as probe for Co 2+ through a Fenton-like reaction. 31 While it include complex processed including electronic spinning resonance and chemiluminescence measurements which limit its application.…”

Section: Introductionmentioning

confidence: 99%

Cobalt(ii) ions detection using carbon dots as an sensitive and selective fluorescent probe

et al. 2016

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A simple method was designed for detecting cobalt ions (Co 2+ ) based on the analyte induced fluorescence quenching of carbon dots (CDs). CDs with a quantum yield of 38.7% were synthesized by hydrothermal treatment of carbopol 934 and diethylenetriamine. Through the metal-ligand interaction, the prepared CDs can highly sensitive and selective detection of Co 2+ . The color changes (from transparent to brown) of the solution can be clearly seen with naked eye. This effective sensing platform shows high sensitivity and selectivity towards Co 2+ . Moreover, the CDs are also successfully utilized for monitoring natural water quality about Co 2+ contents.

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“…In the next step MTX was conjugated onto CDsDG through an esterification reaction (DCC/DMAP mediated) between −COOH groups on MTX and −OH groups in DG as shown in Figure . By using an MTT test, researchers found that the CDs-DG-MTX complex was more cytotoxic to C6 glioma cells than the free medication due to the high rate of hydrolysis of ester groups at a lower pH …”

Section: Cds As a Targeted Nanocarrier For Cancer Treatmentmentioning

confidence: 99%

Review of Carbon Dot-Based Drug Conjugates for Cancer Therapy

Dubey

Dhiman

Koner

2023

ACS Appl. Nano Mater.

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Carbon Dots (CDs) are a class of carbon-based nanostructure known as zero-dimensional nanomaterial and have great potential in the field of targeted chemotherapy. CDs have been extensively explored for bioimaging, sensing, and therapy due to their high quantum yield, low cytotoxicity, high water solubility, good photostability, and tunable excitation wavelength-dependent emission properties. CDs conjugated with various anticancer drugs such as Doxorubicin (DOX), Epirubicin and Temozolomide, Protoporphyrin IX (PpIX), 5-Fluorouracil, Curcumin, Gemcitabine, Methotrexate (MTX), Oxaliplatin, and Cisplatin are explored for chemotherapy applications. These drugs are conjugated with CDs via covalent bond formation such as amide, ester, and hydrazine or with the help of noncovalent electrostatic attraction from opposite charges and hydrogen-bonding interactions. The release of these drug molecules can be controlled with the help of the acidic pH or via highly reactive and abundant small molecular species present in a cancerous environment compared to normal physiological conditions. The CDs-drug conjugate can be specifically released in a targeted manner with the help of a specific substrate attached at the surface and their interaction with overexpressed cell surface receptors. In this review, we demonstrate the application of CDs-drug conjugate toward drug delivery systems for oncology applications.

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Methotrexate anchored carbon dots as theranostic probes: digitonin conjugation enhances cellular uptake and cytotoxicity

Abstract: Digitonin conjugation significantly improves the theranostic potential of methotrexate amended carbon dots.

Cited by 10 publications

References 27 publications

Recent advance of carbon dots in bio-related applications

Recent advance of carbon dots in bio-related applications

Cobalt(ii) ions detection using carbon dots as an sensitive and selective fluorescent probe

Review of Carbon Dot-Based Drug Conjugates for Cancer Therapy

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