Methotrexate

A novel approach to non-invasive glucose measurement by mid-infrared spectroscopy: The combination of quantum cascade lasers (QCL) and photoacoustic detection

“…There is abundant information about the glucose concentration in the extracellular fluid of the stratum spinosum which follows very closely the behaviour of the blood glucose concentration [10,11]. On one hand, the extracellular fluid covers only 20% of the volume of the tissue layer reached by the MIR energy [12]. It is unknown how the intracellular glucose in the keratinocytes relates to the extracellular concentration.…”

Transdermal delivery of levonorgestrel

“…It has been estimated that the intercellular space occupies 15-18% of the total epidermal volume. 38 The dermis is essentially an aqueous phase containing an extracellular matrix consisting of collagen fibers and elastin embedded in mucopolysaccharides. A variety of cells (fibroblasts, fibrocytes, and histiocytes) are embedded in the extracellular matrix.…”

Reticulosis as a Long-Term Side-Effect of Methotrexate Therapy in a Patient with Generalized Psoriasis and Psoriatic Arthritis

“…In psoriasis the turnover rate of epithelial cells is normalized. Other tissues with a high degree of mitotic activity are affected likewise which leads to the well-known side-effects on bone marrow, oral and gastro-intestinal mucosa and hair matrix [8,12,17,18]. The liver function may also be im paired [3-5, 7, 15, 20], In psoriasis as a benign disease the total dosage is usually kept relatively low and the periods of administration are limited to several weeks or months.…”