Methods to Determine Complex Degrees of Mutual Anisotropy for the Differentiation of Hemorrhages in the Human Brain Substance Resulting From Traumatic and Non-Traumatic Genesis

Abstract

An issue that is often debated in forensic traumatology is the differential diagnosis of hemorrhages into the human brain substance (HBS) of traumatic and non-traumatic genesis.
 Objectives. This study aims to identify new criteria for objective forensic differentiation of hemorrhages of traumatic origin, cerebral infarction of ischemic and hemorrhagic genesis by using the method of complex degree of mutual anisotropy. For this study native sections of HBS from 125 corpses were used in the case of: death from coronary heart disease - 35 (28%) of native sections (Group 1 - control); hemorrhages of traumatic genesis - 30 (24%) sections (Group 2); ischemic cerebral infarction - 30 (24%) native sections(Group 3); and hemorrhages of non-traumatic genesis - 30 (24%) native sections (Group 4).
 Results. The statistical moments of the third and fourth orders, which characterize the asymmetry and excess of the complex degree of mutual anisotropy module size distributions, the strength of the method of polarization-correlation microscopy in the differentiation of the samples of the histological sections of the brain of control and experimental groups reached a good level — 87%-90%.
 Conclusion. The method of complex degree of mutual anisotropy allows differentiating with great precision the genesis of hemorrhage into the substance of the brain.

To Develop Forensic Criteria for the Differential Diagnosis of Intracerebral Hemorrhage of Traumatic and Non-Traumatic Origin Using Mueller-Matrix Microscopy of Linear Dichroism

“…At the next step of the research, we analyzed the strength of the azimuthal-invariant MM polarimetry method to distinguish the cause of death between research groups. An increase in the value of sensitivity (Se,%), specificity (Sp,%), and balanced accuracy (Ac,%) in 14% -19% compared to the data of previous MM-mapping researches of TMS (Garazdiuk et al, 2020).…”

“…(Sivokorovskaya et al, 2020) demonstrated the role of polarization-phase diagnostics of the volume of blood loss. Our previous studies demonstrated the efficacy of thin-layer polarization tomography to differentiate the origin of hemorrhage into the brain (Garazdiuk et al, 2020). For a forensic expert-practitioner, the main thing is objectivity, accuracy, and speed of obtaining the result, which could fully satisfy the 1 Bukovinian State Medical University, Department of Forensic Medicine and Medical Law, Chernivtsi, Ukraine, m.garazdiuk@gmail.com, ORCID 0000-0003-1536-4440 2 Bukovinian State Medical University, Department of Forensic Medicine and Medical Law, Chernivtsi, Ukraine, sudmed@bsmu.edu.ua, ORCID 0000-0002-6955-7507 3 Bukovinian State Medical University, Department of anesthesiology and reanimatology, Chernivtsi, Ukraine, olena.nechytailo@bsmu.edu.ua, ORCID 0000-0003-3932-4902 4 Bukovinian State Medical University, Internal Medicine and Infectious Diseases Department, Chernivtsi, Ukraine, olexandr.harazdiuk@gmail.com, ORCID 0000-0002-0430-7558 methods of laser polarimetry in the case of differential diagnosis of hemorrhages of traumatic and nontraumatic origin in the human brain (Hao & Wang, 2017).…”