Methods of preparation of metal-doped and hybrid tungsten oxide nanoparticles for anticancer, antibacterial, and biosensing applications

Sharma, Anirudh; Saini, Adesh K.; Kumar, Nitin; Tejwan, Neeraj; Singh, Th. Abhishek; Thakur, Vijay Kumar; Das, Joydeep

doi:10.1016/j.surfin.2021.101641

Cited by 26 publications

(21 citation statements)

References 93 publications

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“…Te most extensively used process for preparing metal peroxides is hydrolyzation-precipitation [100,195]. Metal chloride, metal acetate, or metal carbonate are commonly utilized as precursors in this process, which involves adding hydrogen peroxide to an alkaline aqueous medium of metal salt to precipitate the water-insoluble metal peroxide particles [196]. Te procedure is relatively simple and is carried out under mild conditions making the process to be cheap, and the size of NPs may be controlled to several nanometres.…”

Section: Synthetic Procedures For Metal Peroxidesmentioning

confidence: 99%

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Mbugua

2022

Bioinorganic Chemistry and Applications

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Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.

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Section: Synthetic Procedures For Metal Peroxidesmentioning

confidence: 99%

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Mbugua

2022

Bioinorganic Chemistry and Applications

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“…For example, Pooyodying, et al, focused on the coating of WO 3 on PET/ITO substrates [ 22 ]. In addition, there are different phases of WO 3, such as orthorhombic, monoclinic (m-WO 3 ), triclinic, tetragonal (t-WO 3 ), hexagonal (h-WO 3 ), etc., [ 23 , 24 , 25 , 26 , 27 ]. The structure of WO 3 prepared by these synthesis methods is mostly orthorhombic and monoclinic phase [ 23 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, there are different phases of WO 3, such as orthorhombic, monoclinic (m-WO 3 ), triclinic, tetragonal (t-WO 3 ), hexagonal (h-WO 3 ), etc., [ 23 , 24 , 25 , 26 , 27 ]. The structure of WO 3 prepared by these synthesis methods is mostly orthorhombic and monoclinic phase [ 23 , 28 , 29 ]. In this paper, a novel method was the preparation of the WO 3 layer on tungsten foil via direct oxidization at high temperatures.…”

Section: Introductionmentioning

confidence: 99%

Study of a Novel Electrochromic Device with Crystalline WO3 and Gel Electrolyte

Chen

Zhang

et al. 2022

Polymers

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Most ECDs are coated with an electrochromic material on the transparent conductive oxide (TCO) substrate. A novel electrochromic device (ECD), having a variable optical performance, was prepared by using tungsten foil as a substrate in this study. It was found that the WO3 discoloration layer, having a monoclinic phase crystalline structure made of 600 °C calcined, had optimum charge transmission performance with PADA gel polymer electrolyte. Ionic conductivity of PADA gel polymer electrolyte was 2.3 × 10−3 S cm−1 at −20 °C, and it was possible to help Li+ to implement embedding and extraction from WO3 even in low-temperature conditions. The colored time (tc) and the bleached time (tb) of the electrochromic device were 15 s and 26 s, and it showed yellowish-brown in the colored state and navy blue in the bleached state. The ECD (WO3-600) exhibited good cycle stability reach at least 150 times.

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“…Nanomedicine is the presentation of technology in the medical field, and lately, it has contributed to the diagnosis and treatment of a variety of diseases (i.e., cancers) [22][23][24][25][26][27][28][29][30][31][32][33]. It is quite possible to deliver the drug to a specific target, which is also known as vectorization.…”

Section: Introductionmentioning

confidence: 99%

“…Nanomedicine is used to deliver submicron-sized particles to the target systems for various theranostic purposes [28,[34][35][36][37][38][39][40][41][42]. Several nanoparticles (NPs) and nanotechnology-based approaches have been lately introduced for fighting cancer [22,23,27,28,43]. Thanks to unique optical properties, wide excitation spectra, and a very narrow symmetrical intense distribution, it has become possible to apply semiconductor quantum dots (QDs) as a versatile material system with high potential for biomedical applications [44][45][46].…”

Section: Introductionmentioning

confidence: 99%

Quantum Dots: Synthesis, Antibody Conjugation, and HER2-Receptor Targeting for Breast Cancer Therapy

Fatima

Rahdar

Sargazi

et al. 2021

JFB

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Breast cancer is becoming one of the main lethal carcinomas in the recent era, and its occurrence rate is increasing day by day. There are different breast cancer biomarkers, and their overexpression takes place in the metastasis of cancer cells. The most prevalent breast cancer biomarker is the human epidermal growth factor receptor2 (HER2). As this biomarker is overexpressed in malignant breast tissues, it has become the main focus in targeted therapies to fight breast cancer. There is a cascade of mechanisms involved in metastasis and cell proliferation in cancer cells. Nanotechnology has become extremely advanced in targeting and imaging cancerous cells. Quantum dots (QDs) are semiconductor NPs, and they are used for bioimaging, biolabeling, and biosensing. They are synthesized by different approaches such as top-down, bottom-up, and synthetic methods. Fully human monoclonal antibodies synthesized using transgenic mice having human immunoglobulin are used to target malignant cells. For the HER2 receptor, herceptin® (trastuzumab) is the most specific antibody (Ab), and it is conjugated with QDs by using different types of coupling mechanisms. This quantum dot monoclonal antibody (QD-mAb) conjugate is localized by injecting it into the blood vessel. After the injection, it goes through a series of steps to reach the intracellular space, and bioimaging of specifically the HER2 receptor occurs, where apoptosis of the cancer cells takes place either by the liberation of Ab or the free radicals.

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Methods of preparation of metal-doped and hybrid tungsten oxide nanoparticles for anticancer, antibacterial, and biosensing applications

Cited by 26 publications

References 93 publications

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Study of a Novel Electrochromic Device with Crystalline WO3 and Gel Electrolyte

Quantum Dots: Synthesis, Antibody Conjugation, and HER2-Receptor Targeting for Breast Cancer Therapy

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