Methods of Particle Production

Charbit,; Gérard,; Boutin, Olivier; Badens, Elisabeth

doi:10.1201/9780203021378.pt2

Cited by 17 publications

(16 citation statements)

References 65 publications

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“…Additionally, recent works on precipitation of rosemary antioxidants can reviewed in Visentín et al [178,179]. Comprehensive reviews on different methods to produce solid particles and liposomes can be found elsewhere [180,181]. Additionally, high-pressure micronization and product formulation using supercritical fluids for food and pharmaceutical applications can be found in the excellent reviews of Weidner [182] and Knez et al [183].…”

mentioning

confidence: 97%

Fractionation technologies for liquid mixtures using dense carbon dioxide

Bejarano

Simões

Valle

2016

The Journal of Supercritical Fluids

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confidence: 97%

Fractionation technologies for liquid mixtures using dense carbon dioxide

Bejarano

Simões

Valle

2016

The Journal of Supercritical Fluids

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“…As noted by Bleich, et al that the nozzle helps to form smaller droplets, hence smaller particles, however this difference is not so clear at high liquid flow rates with capillaries (61). For methylene chloride the jet breakup disappears for a capillary of 150 µm and flow rate of 180 mL/h, which is when atomization is realised (61). Furthermore, the nozzle vs. capillary effect may not always matter, as the material being investigated is not always affected by the SCF conditions/parameters, e.g.…”

Section: Aerosol Solvent Extraction System (Ases)mentioning

confidence: 92%

“…The experimental set up is similar to that for SAS and GAS except that there is a basic nozzle instead of a capillary (injector inlet) ( Figure 3B). As noted by Bleich, et al that the nozzle helps to form smaller droplets, hence smaller particles, however this difference is not so clear at high liquid flow rates with capillaries (61). For methylene chloride the jet breakup disappears for a capillary of 150 µm and flow rate of 180 mL/h, which is when atomization is realised (61).…”

Section: Aerosol Solvent Extraction System (Ases)mentioning

confidence: 94%

“…It is worth mentioning that there are somewhat interchangeable terms regarding the way the SCF phases are formed. By convention the gas antisolvent (GAS) method (presented in more detail in the subsequent section) is one where a compressed gas is progressively added to a solution containing a bioactive and primary solvent until a SCF/dense gas state is reached, whereas the SAS method has the solution of bioactive and solvent sprayed continuously into a SCF or as the case may be, a dense gas (near supercritical fluid conditions) (61). For the purpose of this review, where it is obvious for the SAS method described, it is assumed that a SCF state has been achieved, unless otherwise stated and the API solution is sprayed continuously into the SCF phase.…”

Section: Supercritical Anti-solvent (Sas) Processmentioning

confidence: 99%

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Supercritical Fluid Technologies to Fabricate Proliposomes

et al. 2015

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Proliposomes are stable drug carrier systems designed to form liposomes upon addition of an aqueous phase. In this review, current trends in the use of supercritical fluid (SCF) technologies to prepare proliposomes are discussed. SCF methods are used in pharmaceutical research and industry to address limitations associated with conventional methods of pro/liposome fabrication. The SCF solvent methods of proliposome preparation are eco-friendly (known as green technology) and, along with the SCF anti-solvent methods, could be advantageous over conventional methods; enabling better design of particle morphology (size and shape). The major hurdles of SCF methods include poor scalability to industrial manufacturing which may result in variable particle characteristics. In the case of SCF anti-solvent methods, another hurdle is the reliance on organic solvents. However, the amount of solvent required is typically less than that used by the conventional methods. Another hurdle is that most of the SCF methods used have complicated manufacturing processes, although once the setup has been completed, SCF technologies offer a single-step process in the preparation of proliposomes compared to the multiple steps required by many other methods. Furthermore, there is limited research into how proliposomes will be converted into liposomes for the end-user, and how such a product can be prepared reproducibly in terms of vesicle size and drug loading. These hurdles must be overcome and with more research, SCF methods, especially where the SCF acts as a solvent, have the potential to offer a strong alternative to the conventional methods to prepare proliposomes. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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“…Although, the medical benefits associated with these formulations are evident, they are not widely used because of the manufacturing difficulties encountered with conventional techniques like spray-drying and hot melt extrusion. In the late 80's, supercritical fluids (SCFs) appeared in the pharmaceutical industry as an alternative to conventional processes (Rogers et al, 2001;Charbit et al, 2004;Majerik et al, 2004). The most common SCF is carbon dioxide (scCO 2 ) which is nontoxic, non-flammable and available in large quantities.…”

Section: Introductionmentioning

confidence: 98%

Supercritical Antisolvent Versus Coevaporation— Preparation and Characterization of Solid Dispersions

Majerik

Horváth

Szokonya

et al. 2007

Drug Development and Industrial Pharmacy

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The objective of this work was to improve the dissolution rate and aqueous solubility of oxeglitazar. Solid dispersions of oxeglitazar in PVP K17 (polyvinilpyrrolidone) and poloxamer 407 (polyoxyethylene-polyoxypropylene block copolymer) were prepared by supercritical antisolvent (SAS) and coevaporation (CoE) methods. Drug-carrier formulations were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, gas chromatography, UV/VIS spectroscopy and in vitro dissolution tests. The highest dissolution rate (nearly 3-fold higher than raw drug) was achieved by preparation of drug/PVP K17 coevaporate. Oxeglitazar/PVP K17 solid dispersions were stabilized by hydrogen bonding but contained higher amount of residual dichloromethane (DCM) than poloxamer 407 formulations regardless of the method of preparation. SAS prepared oxeglitazar/poloxamer 407 dissolved more than two times faster than raw drug. However, unlike PVP K17, poloxamer 407 did not form a single phase amorphous solid solution with oxeglitazar which has been manifested in higher degrees of crystallinity, too. Among the two techniques, evaluated in this work, conventional coevaporation resulted in higher amorphous content but SAS reduced residual solvent content more efficiently.

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Methods of Particle Production

Cited by 17 publications

References 65 publications

Fractionation technologies for liquid mixtures using dense carbon dioxide

Fractionation technologies for liquid mixtures using dense carbon dioxide

Supercritical Fluid Technologies to Fabricate Proliposomes

Supercritical Antisolvent Versus Coevaporation— Preparation and Characterization of Solid Dispersions

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