Methods of Evaluation of the Antimicrobial Activity of Medicinal Preparations

Abstract

Methods of evaluation of the antimicrobial activity of nonsterile medicinal preparations are considered. A modified method according to the State Pharmacopoeia (XIth Ed.) is compared to an alternative replication technique applicable to water-insoluble products and also to fatty and colored preparations. The replication method has the advantage of being economical (use of only two culture media), fast (24 -72 h), and universal (admitting the use of a broad set of test microbes). The final choice of the method depends primarily on the nature of each particular preparation. 278 0091-150X/05/3905-0278

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

“…20 Daily cultures of the test strains were diluted ten-fold by the serial dissolution method using a 0.9% isotonic solution of sodium chloride up to a concentration of 10 5 colony forming units/mL and 10 4 colony forming units/mL for bacteria and fungi, respectively.…”