Methods of augmentation of antidepressant therapy (on the model of complex therapy with the inclusion of actovegin) in gerontopsychiatric hospital

Abstract

Депрессии, как и деменция, представляют собой наиболее распространенные формы психической патологии позднего возраста. Депрессивные расстройства в широком смысле, от первичных «больших» до вторичных симптоматических, адаптационных и «подпороговых» малых, встречаются у 10-25% пожилых людей [1-3]. Депрессии в старости приводят к резкому ухудшению качества жизни пожилых лю

The Effect of Chronic Mild Stress and Venlafaxine on the Expression and Methylation Levels of Genes Involved in the Tryptophan Catabolites Pathway in the Blood and Brain Structures of Rats

“…In addition to SSRIs, serotonin-norepinephrine reuptake inhibitors (SNRIs), including venlafaxine, are the first line of depression therapy. Venlafaxine is approved by the US Food and Drug Administration (FDA) to treat and manage symptoms of depression, general anxiety disorder, social phobia and panic disorder (Safarova et al 2018 ). Venlafaxine is a bicyclic phenylethylamine compound and works by blocking the transporter “reuptake” proteins for key neurotransmitters, including serotonin and norepinephrine, thereby leaving more active neurotransmitters in the synapse.…”

Placebo in the guise of evidence-based medications

“…A favorable effect of HPCH in stroke patients 144 may be caused by a nutritional supplementation, which is known to reduce morbidity and mortality after stroke 158 . Efficiency of HPCH as well as of other meat-derived substances such as carnosine and taurine 141 in patients with dementia, depression, other mental and neurological disorders [145][146][147][148]159 should be further studied as possible markers of malnutrition and protein deficiency e.g. among inhabitants of homes for the aged and psychiatric hospitals.…”