Methods, models, mechanisms and metadata: Introducing the Nanotoxicology collection at F1000Research

Abstract

Nanotoxicology is a relatively new field of research concerning the study and application of nanomaterials to evaluate the potential for harmful effects in parallel with the development of applications. Nanotoxicology as a field spans materials synthesis and characterisation, assessment of fate and behaviour, exposure science, toxicology / ecotoxicology, molecular biology and toxicogenomics, epidemiology, safe and sustainable by design approaches, and chemoinformatics and nanoinformatics, thus requiring scientists to work collaboratively, often outside their core expertise area. This interdisciplinarity can lead to challenges in terms of interpretation and reporting, and calls for a platform for sharing of best-practice in nanotoxicology research. The F1000Research Nanotoxicology collection, introduced via this editorial, will provide a place to share accumulated best practice, via original research reports including no-effects studies, protocols and methods papers, software reports and living systematic reviews, which can be updated as new knowledge emerges or as the domain of applicability of the method, model or software is expanded. This editorial introduces the Nanotoxicology Collection in F1000Research. The aim of the collection is to provide an open access platform for nanotoxicology researchers, to support an improved culture of data sharing and documentation of evolving protocols, biological and computational models, software tools and datasets, that can be applied and built upon to develop predictive models and move towards in silico nanotoxicology and nanoinformatics. Submissions will be assessed for fit to the collection and subjected to the F1000Research open peer review process.

Nanotoxicology: Scopus and Pubmed Data Mining and Bibliographic Map Comparative Analysis Using VOSviewer Software

“…Understanding the mechanism of action of nanoparticles in different organisms and in the environment remains a challenge to be overcome by researchers worldwide. Recent trends in nanotoxicology include incorporation of high-throughput screening approaches to establish structureactivity relationships using libraries of NPs with different properties and in vitro screening assays combined with computational analysis; omics-approaches, including metabolomics, proteomics, and transcriptomics, to discover molecular-level effects of NPs at low and sub-lethal concentrations; and method development to include sensitive toxicity assays for early detection of toxic effects [18][19][20][21].…”

Toxicology of carbon nanomaterials in the Caenorhabditis elegans model: current status, characterization, and perspectives for testing harmonization

“…In addition to the harmonization, one of the challenges to understanding CNM toxicity is interpreting and comparing the large volume of published data collected under a wide range of exposure conditions. The generation of data and no compilation of that with the physicochemical characterization of carbon nanomaterials do not contribute to generating mathematical models that can predict the toxicological effects (Lynch et al, 2021). Scientific publications in this field need to improve this aspect.…”