Methods matter: clinical prediction models will benefit sports medicine practice, but only if they are properly developed and validated

Bullock, Garrett S.; Hughes, Tom; Sergeant, Jamie C.; Callaghan, Michael J.; Riley, Richard D; Collins, Gary S.

doi:10.1136/bjsports-2021-104329

Cited by 23 publications

(21 citation statements)

References 10 publications

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“…There is also no assurance on how AI models will be monitored and audited in the event of adverse outcomes. Recent publications from the fields of sports medicine and oncology reflect these complexities ( 21 , 22 ).…”

Section: The Chaos Of Humans and Healthcarementioning

confidence: 99%

Artificial Intelligence and Statistics: Just the Old Wine in New Wineskins?

Faes

Sim

Smeden

et al. 2022

Front. Digit. Health

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Section: The Chaos Of Humans and Healthcarementioning

confidence: 99%

Artificial Intelligence and Statistics: Just the Old Wine in New Wineskins?

Faes

Sim

Smeden

et al. 2022

Front. Digit. Health

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“…Klotho: a potent target for sports sciences and medicine. The prevention and rehabilitation of various sports injuries has been widely studied [77][78][79][80] . Baseline characteristics such as muscle strength, body composition, and levels of athleticism may influence injury prediction 78 .…”

Section: Exercise Training Protocols In S-klotho Responsementioning

confidence: 99%

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine

Corrêa

Raab²,

Araújo³

et al. 2022

Sci Rep

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Klotho is an anti-aging protein with several therapeutic roles in the pathophysiology of different organs, such as the skeletal muscle and kidneys. Available evidence suggests that exercise increases Klotho levels, regardless of the condition or intervention, shedding some light on this anti-aging protein as an emergent and promising exerkine. Development of a systematic review and meta-analysis in order to verify the role of different exercise training protocols on the levels of circulating soluble Klotho (S-Klotho) protein. A systematic search of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE through PubMed, EMBASE, CINAHL, CT.gov, and PEDro. Randomized and quasi-randomized controlled trials that investigated effects of exercise training on S-Klotho levels. We included 12 reports in the analysis, comprising 621 participants with age ranging from 30 to 65 years old. Klotho concentration increased significantly after chronic exercise training (minimum of 12 weeks) (Hedge’ g [95%CI] 1.3 [0.69–1.90]; P < 0.0001). Moreover, exercise training increases S-Klotho values regardless of the health condition of the individual or the exercise intervention, with the exception of combined aerobic + resistance training. Furthermore, protocol duration and volume seem to influence S-Klotho concentration, since the effect of the meta-analysis changes when subgrouping these variables. Altogether, circulating S-Klotho protein is altered after chronic exercise training and it might be considered an exerkine. However, this effect may be influenced by different training configurations, including protocol duration, volume, and intensity.

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“…The prevention and rehabilitation of various sports injuries has been widely studied [75][76][77][78] . Baseline characteristics such as muscle strength, body composition, and levels of athleticism may in uence injury prediction 76 .…”

Section: Klotho: a Potent Target For Sports Sciences And Medicinementioning

confidence: 99%

Klotho, much more than an anti-aging protein, an emerging exerkine: A systematic review and meta-analysis

Corrêa

Raab

Araújo

et al. 2022

Preprint

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Background: Klotho is an anti-aging protein with several therapeutic roles in the pathophysiology of different organs, such as the skeletal muscle and kidneys. Available evidence suggests that exercise increases Klotho levels, regardless of the condition or intervention, shedding some light on this anti-aging protein as an emergent and promising exerkine. Objective: Development of a systematic review and meta-analysis in order to verify the role of different exercise training protocols on the levels of circulating soluble Klotho (S-Klotho) protein. Data sources: A systematic search of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE through PubMed, EMBASE, CINAHL, CT.gov, and PEDro. Eligibility criteria: Randomized and quasi-randomized controlled trials that investigated effects of exercise training on S-Klotho levels. Results: We included 12 reports in the analysis, comprising 621 participants with age ranging from 30 to 65 years old. Klotho concentration increased significantly after chronic exercise training (minimum of 12 weeks) (Hedge’ g [95%CI] 1.3 [0.69 – 1.90]; P < 0.0001). Moreover, exercise training increases S-Klotho values regardless of the health condition of the individual or the exercise intervention, with the exception of combined aerobic + resistance training. Furthermore, protocol duration and volume seem to influence S-Klotho concentration, since the effect of the meta-analysis changes when subgrouping these variables. Conclusion: Altogether, circulating S-Klotho protein is altered after chronic exercise training and it might be considered an exerkine. However, this effect may be influenced by different training configurations, including protocol duration, volume, and intensity.

show abstract

Methods matter: clinical prediction models will benefit sports medicine practice, but only if they are properly developed and validated

Cited by 23 publications

References 10 publications

Artificial Intelligence and Statistics: Just the Old Wine in New Wineskins?

Artificial Intelligence and Statistics: Just the Old Wine in New Wineskins?

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine

Klotho, much more than an anti-aging protein, an emerging exerkine: A systematic review and meta-analysis

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