Methods for Photoultrasonic Treatment of Festering Wounds in Oncological Patients

Zharov, Vladimir P.; Menyaev, Yulian A.; Gorchak, Yu. Yu.; Utkina, Karina; Menyaev, Ya. A.

doi:10.1615/critrevbiomedeng.v29.i1.50

Cited by 4 publications

(4 citation statements)

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“…The efficacy of PDT, however, is dependent on tissue oxidation and bacterial infections in hypoxic environments, as seen in the late stages of osteomyelitis, may not be treatable with PDT [15] . Sonodynamic therapy [16] – [22] using ultrasound-triggered cavitation alone (see review in [21] ), or in combination with PDT could be promising approach, especially by providing synergy of sono and PDT treatment [20] – [22] . As a possible alternative, nanotechnology using nanoparticles (NPs) of different composition, shapes or sizes (e.g., gold nanoshells, nanorods, magnetic NPs [MNPs], carbon nanotubes, or golden carbon nanotubes [GNTs]) have been extensively explored either as imaging contrast agents, as a transformer of various energy (e.g., laser, ultrasound, and radio-waves) to thermal and accompanied therapeutic effects (e.g., nanobubbles) or as the vehicles for drug delivery [23] – [35] using continuous wave (CW) [24] and pulse [23] lasers.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Magnetic Enrichment, Photoacoustic Diagnosis, and Photothermal Purging of Infected Blood Using Multifunctional Gold and Magnetic Nanoparticles

et al. 2012

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Bacterial infections are a primary cause of morbidity and mortality worldwide. Bacteremia is a particular concern owing to the possibility of septic shock and the development of metastatic infections. Treatment of bacteremia is increasingly compromised by the emergence of antibiotic resistant strains, creating an urgent need for alternative therapy. Here, we introduce a method for in vivo photoacoustic (PA) detection and photothermal (PT) eradication of Staphylococcus aureus in tissue and blood. We show that this method could be applicable for label-free diagnosis and treatment of in the bloodstream using intrinsic near-infrared absorption of endogenous carotenoids with nonlinear PA and PT contrast enhancement. To improve sensitivity and specificity for detection of circulating bacteria cells (CBCs), two-color gold and multilayer magnetic nanoparticles with giant amplifications of PA and PT contrasts were functionalized with an antibody cocktail for molecular targeting of S. aureus surface-associated markers such as protein A and lipoprotein. With a murine model, the utility of this approach was demonstrated for ultrasensitive detection of CBCs with threshold sensitivity as low as 0.5 CBCs/mL, in vivo magnetic enrichment of CBCs, PT eradication of CBCs, and real-time monitoring of therapeutic efficacy by CBC counting. Our PA-PT nano-theranostic platform, which integrates in vivo multiplex targeting, magnetic enrichment, signal amplification, multicolor recognition, and feedback control, could be used as a biological tool to gain insights on dissemination pathways of CBCs, infection progression by bacteria re-seeding, and sepsis development and treatment, and could potentially be feasible in humans, especially using bypass schematic.

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Section: Introductionmentioning

confidence: 99%

In Vivo Magnetic Enrichment, Photoacoustic Diagnosis, and Photothermal Purging of Infected Blood Using Multifunctional Gold and Magnetic Nanoparticles

et al. 2012

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“…7 and Semashko Central Clinical Hospital No. 4 [9]. In all cases oncological lesions of gastrointestinal tract or urinary system were indications for surgery.…”

Section: Tpms In Combination With Medication Therapymentioning

confidence: 99%

Experience in the use of therapeutic photomatrix equipment

Menyaev

Zharov

2006

Biomed Eng

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“…The photomatrix therapeutic system (PMTS), in its generalized form, is a net of light-emitting diode (LED) irradiation sources on a dimensional plane, and the LEDs themselves are located in the nodes of this grid, which in turn is fixed by the given spatial dimensions [1][2][3][4][5][6]. The issues of designing PMTS medical devices have already been described, making it possible to combine three principal aspects: illumination and optical characteristics of LEDs, their spatial and geometric arrangement on the surface of matrix substrate, and also the parameters of photobiological influence on the body in the context of the given biomedical requirements [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…In general, over thirty different types of PMTS are presently available on the market or known as laboratory prototypes. The following operating modes of PMTS have been demonstrated [1][2][3][4][5][6][7][8][9][10][11][12][13]: constant, when all LEDs are on, but no modulation of irradiation is performed; blinking, where the LED sources are switched on at a specified frequency; blinking with pulse rate biosynchronization (based on pulse oximetry using a fingertip), in this case, the emission intensity of all LEDs is directly proportional to the volume of arterial blood supplying the vessels; looped modes of sequential single activation of each source or all LEDs lying on the same coordinate line; a variety of schematic modes such as 'treadmill' or specially designed modifiable 'patterns'; modes of sequential or predetermined changes in the wavelengths of the LED irradiation (in the case of tunable sources); various stochastic modes for turning on the LEDs that are controlled using a connected random number generator; and others.…”

Section: Introductionmentioning

confidence: 99%

Designing the Uniform Stochastic Photomatrix Therapeutic Systems

2020

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Photomatrix therapeutic systems (PMTS) are widely used for the tasks of preventive, stimulating and rehabilitation medicine. They consist of low-intensity light-emitting diodes (LEDs) having the quasi-monochromatic irradiation properties. Depending on the LED matrix structures, PMTS are intended to be used for local and large areas of bio-objects. However, in the case of non-uniform irradiation of biological tissues, there is a risk of an inadequate physiological response to this type of exposure. The proposed approach considers a novel technique for designing this type of biomedical technical systems, which use the capabilities of stochastic algorithms for LED switching. As a result, the use of stochastic photomatrix systems based on the technology of uniform twisting generation of random variables significantly expands the possibilities of their medical application.Algorithms 2020, 13, 41 2 of 21 occurs at the molecular, cellular, tissue, organ, and systemic levels in the bio-object. The main effects of phototherapy should be considered a systemic improvement in metabolism, as well as the normalization of blood flow components, for example, blood viscosity, microcirculation and rheology parameters, immunologic responses, and secondary regenerative processes, among others [21][22][23][24][25][26][27]. As a result, expressed therapeutic effects are achieved, such as biostimulatory, anti-inflammatory, analgesic, and decongestant effects, and many others.Several typical medical PMTS are presented in Figure 1. In particular, Figure 1A shows a cylindrical apparatus for photomatrix action on extremities of hands and feet, and Figure 1B presents a semicylindrical apparatus for the integral irradiation of extended skin surfaces, such as the abdomen or back. In addition to devices for the LED exposure alone, there are also combinations with other various sources of low-intensity physiotherapy. In particular, Figure 1C shows an apparatus that combines both LED irradiation and negative low-intensity pressure for the treatment of copulative dysfunction; Figure 1D displays a photo-ultrasound tool for treating the infected and purulent-necrotic wounds, which consists of a spherical segment of PMTS and a low-frequency ultrasonic waveguide; Figure 1E demonstrates a device combining LEDs of various wavelengths and a low-intensity magnetic field to affect various systems of the human body, for example, nervous, circulatory, musculoskeletal, etc., in order to enhance metabolic processes. In addition to the rigid frames in which the LEDs are fixed, there are also many PMTS based on flexible substrates, which provide a more accurate correspondence to the reliefs of biological tissues. Therefore, Figure 1F presents a semi-flexible construction of PMTS designed for various medical tasks based on LED phototherapy. In general, over thirty different types of PMTS are presently available on the market or known as laboratory prototypes.Algorithms 2020, 13, x FOR PEER REVIEW 2 of 21

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Methods for Photoultrasonic Treatment of Festering Wounds in Oncological Patients

Cited by 4 publications

References 0 publications

In Vivo Magnetic Enrichment, Photoacoustic Diagnosis, and Photothermal Purging of Infected Blood Using Multifunctional Gold and Magnetic Nanoparticles

In Vivo Magnetic Enrichment, Photoacoustic Diagnosis, and Photothermal Purging of Infected Blood Using Multifunctional Gold and Magnetic Nanoparticles

Experience in the use of therapeutic photomatrix equipment

Designing the Uniform Stochastic Photomatrix Therapeutic Systems

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