Methods for Intracellular Delivery of Quantum Dots

Souza, Sueden O.; Lira, Rafael B.; Cunha, Cássia R.A.; Santos, Beate S.; Fontes, Adriana; Pereira, Goreti

doi:10.1007/s41061-020-00313-7

Cited by 57 publications

(12 citation statements)

References 120 publications

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“…Further, in vivo animal experiments also proved that monocytes preferentially capture the liposomal delivery system of QDs rather than free QDs [87]. However, liposomes encapsulating QDs may also increase the difficulty of cell internalization because of larger size, thus blocking the release of QDs or drugs from liposomes near the target site [86].…”

Section: Liposomes Loading Semiconductor Quantum Dotsmentioning

confidence: 98%

“…also observed increased cellular internalization and lower cytotoxicity of the CdSe-ZnS QD-liposome system [85]. Moreover, researchers investigated the photostability of QDs when changing pH values and observed the protective effect of liposomes on QDs fluorescence [86]. Aizik et al found that liposomes were able to protect CdSe/CdZnS QDs fluorescence under various conditions, such as low pH, serum-containing medium, and high concentrations of calcium ions [87].…”

Section: Liposomes Loading Semiconductor Quantum Dotsmentioning

confidence: 99%

“…The surface composition and charge of liposomes are parameters that regulate their interactions with cells and absorption mechanisms. Generally, both neutral and anionic liposomes exhibit weaker binding to cell membranes [86]. However, cationic liposomes composed of positively charged lipids can be nonspecifically linked to cell membranes with a negative charge by electrostatic interactions, thus facilitating the delivery of therapeutic agents into cells [159].…”

Section: Design Consideration and Surface Modification Of Nirn-lipsmentioning

confidence: 99%

“…Conventional liposomes are readily absorbed by the reticuloendothelial system during intravenous administration, resulting in a short circulation time [86]. To increase circulation time, the liposomes modified with PEG have been developed.…”

Section: Design Consideration and Surface Modification Of Nirn-lipsmentioning

confidence: 99%

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Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

et al. 2021

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Liposomes are attractive carriers for targeted and controlled drug delivery receiving increasing attention in cancer photothermal therapy. However, the field of creating near-infrared nanomaterial-liposome hybrid nanocarriers (NIRN-Lips) is relatively little understood. The hybrid nanocarriers combine the dual superiority of nanomaterials and liposomes, with more stable particles, enhanced photoluminescence, higher tumor permeability, better tumor-targeted drug delivery, stimulus-responsive drug release, and thus exhibiting better anti-tumor efficacy. Herein, this review covers the liposomes supported various types of near-infrared nanomaterials, including gold-based nanomaterials, carbon-based nanomaterials, and semiconductor quantum dots. Specifically, the NIRN-Lips are described in terms of their feature, synthesis, and drug-release mechanism. The design considerations of NIRN-Lips are highlighted. Further, we briefly introduced the photothermal conversion mechanism of NIRNs and the cell death mechanism induced by photothermal therapy. Subsequently, we provided a brief conclusion of NIRNs-Lips applied in cancer photothermal therapy. Finally, we discussed a synopsis of associated challenges and future perspectives for the applications of NIRN-Lips in cancer photothermal therapy.

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Section: Liposomes Loading Semiconductor Quantum Dotsmentioning

confidence: 98%

Section: Liposomes Loading Semiconductor Quantum Dotsmentioning

confidence: 99%

Section: Design Consideration and Surface Modification Of Nirn-lipsmentioning

confidence: 99%

Section: Design Consideration and Surface Modification Of Nirn-lipsmentioning

confidence: 99%

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Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

et al. 2021

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“…Inorganic nanoparticles possess unique physical and chemical properties suitable for a broad range of biomedical applications, ranging from ultrasensitive molecular assays, multimodal bioimaging, and targeted delivery to activation of drugs . Examples include iron oxide-, platinum-, and bismuth-based nanoparticles being developed as contrast agents in MRI and X-ray imaging, gadolinium − and gold nanoparticles employed in radiosensitizer and drug delivery systems, and semiconductor quantum dots (QDs) used as fluorescent labels. , Lanthanide-doped nanoparticles (LnNPs) have advantageous optical characteristics, including large Stokes/anti-Stokes shifts, long emission lifetimes, excellent photostability, and sharp-band emissions. , These unique properties provides their opportunities for a range of biomedical applications, including ultrasensitive bioassays, deep-tissue super-resolution imaging, , multimodal biomedical imaging, photodynamic therapy, and NIR-triggered release of genes and drugs . LnNPs with spectral downshifting properties have further led to recent progress in the development of NIR deep-tissue imaging applications. , In addition, the high elemental lanthanide content of LnNPs renders them suitable as labels for mass flow cytometry and mass spectroscopy imaging applications, potentially increasing the sensitivity of these assays. − …”

Section: Introductionmentioning

confidence: 99%

Stable and Highly Efficient Antibody–Nanoparticles Conjugation

et al. 2021

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Functional ligands and polymers have frequently been used to yield target-specific bio-nanoconjugates. Herein, we provide a systematic insight into the effect of the chain length of poly(oligo (ethylene glycol) methyl ether acrylate) (POEGMEA) containing polyethylene glycol on the colloidal stability and antibody-conjugation efficiency of nanoparticles. We employed Reversible Addition−Fragmentation Chain Transfer (RAFT) to design diblock copolymers composed of 7 monoacryloxyethyl phosphate (MAEP) units and 6, 13, 35, or 55 OEGMEA units. We find that when the POEGMEA chain is short, the polymer cannot effectively stabilize the nanoparticles, and when the POEGMEA chain is long, the nanoparticles cannot be efficiently conjugated to antibody. In other words, the majority of the carboxylic groups in larger POEGMEA chains are inaccessible to further chemical modification. We demonstrate that the polymer containing 13 OEGMEA units can effectively bind up to 64% of the antibody molecules, while the binding efficiency drops to 50% and 0% for the polymer containing 35 and 55 OEGMEA units. Moreover, flow cytometry assay statistically shows that about 9% of the coupled antibody retained its activity to recognize B220 biomarkers on the B cells. This work suggests a library of stabile, specific, and bioactive lanthanide-doped nanoconjugates for flow cytometry and mass cytometry application.

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Substrate‐Controlled Regioselectivity Switch in a Three‐Component 1,3‐Dipolar Cycloaddition Reaction to Access 3,3′‐Pyrrolidinyl‐Spirooxindoles Derivatives

Wang

Chen

et al. 2022

Adv Synth Catal

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The additive-free 1,3-dipolar cycloaddition reaction of isatin-derived azomethine ylides with αcyano-α,β-unsaturated compounds was developed, which enabled diversity-oriented synthesis of a series of novel and structurally complex 3,3'-pyrrolidinyl-spirooxindoles derivatives containing four contiguous and two quaternary stereogenic centers in high yields (up to 92%) and excellent diastereoselectivities (up to > 25:1 dr). The reaction displays switchable regioselectivity depending on the steric effect of the substrates.

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Methods for Intracellular Delivery of Quantum Dots

Cited by 57 publications

References 120 publications

Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

Stable and Highly Efficient Antibody–Nanoparticles Conjugation

Substrate‐Controlled Regioselectivity Switch in a Three‐Component 1,3‐Dipolar Cycloaddition Reaction to Access 3,3′‐Pyrrolidinyl‐Spirooxindoles Derivatives

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