The paper considers principles of creating promising memristive structures based on composite oxides with agglomerates of nanoparticles. The proposed functional nanomaterial is promising for the formation of a composite structure of a memristor, consisting of two electrodes based on one or more nanoscale layers of metal oxides, which are separated by an active medium so that an insulating layer is applied between the electrodes at the periphery of the active medium region. A conductive layer is formed on top of the insulating layer, which is connected to the negative rail, which prevents leakage of negative oxygen ions through the insulating layer. The authors considered in detail technological process of integral production, which forms the necessary vertical profile of the memristive structure ensuring its greatest stability and repeatability of parameters. The implementation of a hardware-software complex for monitoring and diagnosing a memristive structure is proposed. As a result of the research, an original technical solution was created, which ensures formation of memristive structures with a high efficiency of impact on negative oxygen ions, which are charge carriers in this structure, which ensures their high productivity and stability of parameters.