Methods for direct C(sp²)–H bonds azidation

Abstract

Direct functionalization of C–H bonds has attracted great attention in recent years from the perspectives of atom and step economy.

C–H functionalization of aromatic amines for azidation catalyzed by Betti base coordinated copper(ii) complexes under ultrasonication

“…5 However, owing to their inert aromatic C–H bonds the synthesis of aromatic azides is limited in the literature, unlike aliphatic azides. 6–9…”

“…5 However, owing to their inert aromatic C-H bonds the synthesis of aromatic azides is limited in the literature, unlike aliphatic azides. [6][7][8][9] Interestingly, it was found that copper can facilitate the synthesis of aromatic azides via C-H functionalization. Aniline, a simple aromatic amine, was converted into its corresponding mono-and di-azides using CuBr (10 mol%) with a yield of 46% and 27%, respectively.…”

Direct halosulfonylation of alkynes: an overview

“…11 However, synthesis of b-halovinyl sulfones through the direct halosulfonylation of simple and easily accessible alkynes was almost omitted, while this procedure has recently attracted a lot of attention because of its operational simplicity and high atom and step economy. In connection with our recent reviews on the synthesis of organosulfur compounds 12 and new methodologies in modern organic synthesis, [13][14][15][16][17][18][19][20] herein, we provide an overview of the direct halosulfonylation of C-C triple bonds (Fig. 1), with special emphasize on the mechanistic aspect of the reactions.…”

Progress and recent trends in the direct selenocyanation of (hetero)aromatic C–H bonds

“…Since a number of remarkable developments in this attractive research eld have taken place during the past few years, seems it is an appropriate time to summarize those advances. In continuation of our interest on the direct functionalization of C-H bonds [18][19][20][21] and modern organic synthesis, 22 herein, we will try to provide a comprehensive overview of the synthesis of selenocyanated arenes and heteroarenes through the direct selenocyanation of (hetero)aryl Csp 2 -H bonds (Fig. 1) with an aim to inspire scientists to conduct more research in the eld and develop new and creative synthetic access routes to biologically active organoselenocyanates and other important organoselenium compounds.…”