Methods for Determination of Dioxins and Dioxin-like Compounds – A Brief Review of Recent Advances

Petronijević, Radivoj; Radicevic, Tatjana; Janković, Vesna

doi:10.1016/j.profoo.2015.09.036

Cited by 5 publications

(11 citation statements)

References 18 publications

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“…In the cell, TCDD binds to AhR to form AhR-complex which translocates into the nucleus [20]. Here in, transcription of genes occurs after AhR heterodimerizes with AhR nuclear translocator (ARNT) [8] leading to the production of the well-known protein; cytochrome P-450 (CYP) 1A [88]. There are several other enzymes whose expression is affected by exposure to dioxin and dioxin-like compounds some of which include; an aldehyde dehydrogenase and NADPH-quinone-oxidoreductase enzyme [88].…”

Section: Common Molecular Action Of Dioxinsmentioning

confidence: 99%

“…Here in, transcription of genes occurs after AhR heterodimerizes with AhR nuclear translocator (ARNT) [8] leading to the production of the well-known protein; cytochrome P-450 (CYP) 1A [88]. There are several other enzymes whose expression is affected by exposure to dioxin and dioxin-like compounds some of which include; an aldehyde dehydrogenase and NADPH-quinone-oxidoreductase enzyme [88]. The AhR complex also affects the expression of other genes that influence basic cellular processes such as growth, differentiation and programmed cell death [14,88].…”

Section: Common Molecular Action Of Dioxinsmentioning

confidence: 99%

“…There are several other enzymes whose expression is affected by exposure to dioxin and dioxin-like compounds some of which include; an aldehyde dehydrogenase and NADPH-quinone-oxidoreductase enzyme [88]. The AhR complex also affects the expression of other genes that influence basic cellular processes such as growth, differentiation and programmed cell death [14,88]. Additionally, in the nucleus, AhR releases the bound ligand before it heterodimerizes with another protein such as AhR nuclear translocator (ARNT) [111].…”

Section: Common Molecular Action Of Dioxinsmentioning

confidence: 99%

“…These observed effects of dioxins are attributed to their participation in the metabolic steps of the retinoid activation and metabolism as well as in molecular interactions of the retinoid receptors and AhR in the transactivation system [77]. As a response to the activation by dioxins, the AhR signalling pathways regulates the expression levels of various genes by induction of the gene for a Phase I cytochrome P-450 drug-metabolizing enzyme, CYP1A1 [20,65,81,82], an enzyme involved in oxidation, reduction, and hydroxylation reaction processes [14,88]. The initiation of changes in the expression of these genes begins with the ligand (2020) 2:1729 | https://doi.org/10.1007/s42452-020-03551-y Review Paper binding to the AhR [88].…”

Section: Common Molecular Action Of Dioxinsmentioning

confidence: 99%

“…As a response to the activation by dioxins, the AhR signalling pathways regulates the expression levels of various genes by induction of the gene for a Phase I cytochrome P-450 drug-metabolizing enzyme, CYP1A1 [20,65,81,82], an enzyme involved in oxidation, reduction, and hydroxylation reaction processes [14,88]. The initiation of changes in the expression of these genes begins with the ligand (2020) 2:1729 | https://doi.org/10.1007/s42452-020-03551-y Review Paper binding to the AhR [88]. Generally, induced toxicity via the activation of AhR, prevents AhR from performing its functions, which importantly, includes the maintenance of homeostasis [47,129].…”

Section: Common Molecular Action Of Dioxinsmentioning

confidence: 99%

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A review of persistent organic pollutants: dioxins, furans, and their associated nitrogenated analogues

et al. 2020

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Dioxins and furans are no doubt the most notorious class of organochlorine toxicants in the environmental system whose adverse effects are detrimental to public health with extreme negative economic impacts. Polychlorinated dibenzop-dioxin and dibenzofurans and dioxin-like compounds such as the polychlorinated biphenyls, carbazoles are in the class of persistent organic pollutants-prioritized under the Stockholm convention as the "dirty dozens", besides being listed as group 1 human carcinogens by the International Agency for Research on Cancer. Because of their recalcitrant nature in the environment, bioaccumulation in lipids of cells of animals and their general toxicities, this family of compounds has received increased scientific interest in pollution and toxicology research. Accumulation of these toxicants in lipids of animals, and human exposure has been traced to animal products such as meat, eggs, milk and fish. Combustion events, industrial and municipal waste incineration practices, open fires and some industrial activities especially those dealing with metallurgy are well-established sources of these environmental contaminants. The critical aspects of dioxins, furans and their analogues; notably their sources their mechanistic formation by precursor initiation, de novo pathways, how they manifest their toxicity by activation of aryl hydrocarbon receptor, detoxification of these chemicals from the environment and the analytical methods used to quantify and detect from environmental sample matrices has been explored in this work. This review also provides an in-depth examination of the toxic characteristic behaviour of dioxins and furans, polycyclic aromatic hydrocarbons as well as the emerging nitrogenated analogues of dioxins such as polychlorinated carbazole, and carbazole itself.

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Section: Common Molecular Action Of Dioxinsmentioning

confidence: 99%

Section: Common Molecular Action Of Dioxinsmentioning

confidence: 99%

Section: Common Molecular Action Of Dioxinsmentioning

confidence: 99%

Section: Common Molecular Action Of Dioxinsmentioning

confidence: 99%

Section: Common Molecular Action Of Dioxinsmentioning

confidence: 99%

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A review of persistent organic pollutants: dioxins, furans, and their associated nitrogenated analogues

et al. 2020

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Diet analysis and evaluation

2022

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Adsorption behavior of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on pristine and doped black phosphorene: A DFT study

et al. 2017

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Polychlorinated dibenzo-p-dioxins (PCDDs) are highly toxic to humans. The search for novel and effective methods and materials for detecting or removing these gas pollutants is becoming more important and urgent. With its high specific surface area, abundance, and variety of potential applications, phosphorene has attracted much research interest. In this study, density functional theory was used to study the interactions between a doped phosphorene sheet and a tetrachlorodibenzo-p-dioxin (TCDD) molecule. The initial configurations of the TCDD and metallic (Ca or Ti) or nonmetallic (S and Se) dopants were investigated during the TCDD-phosphorene interaction study. Adsorption energy, isosurface of electron density difference, and density of states analysis were utilized to explore the interactions between TCDD and phosphorene. The results indicated that Ca dopant effectively improved the interaction between TCDD and phosphorene. Se dopant reduced the interaction between TCDD and phosphorene. Combining interactions between TCDD and the pristine, Ca-doped, and Se-doped phosphorenes, phosphorene could be a promising candidate for TCDD sensing and removal.

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Methods for Determination of Dioxins and Dioxin-like Compounds – A Brief Review of Recent Advances

Cited by 5 publications

References 18 publications

A review of persistent organic pollutants: dioxins, furans, and their associated nitrogenated analogues

A review of persistent organic pollutants: dioxins, furans, and their associated nitrogenated analogues

Diet analysis and evaluation

Adsorption behavior of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on pristine and doped black phosphorene: A DFT study

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