Methods for Cellulose Modification in the Development of Polymeric Composite Materials (Review)

Anpilova, A. Yu.; Mastalygina, E. E.; Khrameeva, N. P.; Попов, А. А.

doi:10.1134/s1990793120010029

Cited by 21 publications

(8 citation statements)

References 33 publications

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“…Polysaccharides show high chemical activities because of their abundant functional groups, such as amino and hydroxyl groups ( Yang Y. et al, 2020 ). Several reviews have summarized the synthetic protocols for common polysaccharide derivatives ( Tiwari and Bahadur, 2019 ; Anpilova et al, 2020 ; Yang Y. et al, 2020 ). In the nanomaterial synthesis process, polysaccharides can be reacted under drastic conditions, such as high temperatures, salt contents, and shear forces, with relatively stable structures and biological activities compared with nucleic acids and proteins ( Yuan et al, 2018 ; Garcia-Vaquero et al, 2019 ; Wang et al, 2019a ; Chao et al, 2020 ; Chen B. et al, 2020 ).…”

Section: Typical Ocular Polysaccharide-based Nanocarriers and Novel Dmentioning

confidence: 99%

Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Lin

et al. 2020

Front. Bioeng. Biotechnol.

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Ocular drug delivery is one of the most challenging issues in ophthalmology because of the complex physiological structure of the eye. Polysaccharide-based nanomaterials have been extensively investigated in recent years as ideal carriers for enhancing the bioavailability of drugs in the ocular system because of their biocompatibility and drug solubilization. From this perspective, we discuss the structural instability of polysaccharides and its impact on the synthesis process; examine the potential for developing bioactive polysaccharide-based ocular drug nanocarriers; propose four strategies for designing novel drug delivery nanomaterials; and suggest reviewing the behavior of nanomaterials in ocular tissues.

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Section: Typical Ocular Polysaccharide-based Nanocarriers and Novel Dmentioning

confidence: 99%

Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Lin

et al. 2020

Front. Bioeng. Biotechnol.

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“…The excipients must be non-toxic and non-allergenic, must guarantee an effective therapeutic activity at the lowest therapeutic concentration of the active substance, and must be stable and free of interactions with the active substance [ 32 ]. Cellulose derivatives are widely used as fillers in capsule production [ 33 ]. Fillers constitute the bulk of the encapsulated content; and thus, their inherent properties should not alter the regulated disintegration time of the capsules or the dissolution kinetics of the active compounds.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Biopharmaceutical Evaluation of Capsules Containing Freeze-Dried Cranberry Fruit Powder

Šedbarė

Janulis

Ramanauskienė

2023

Plants

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Cranberry fruits are an important source of anthocyanins and anthocyanidins. The aim of the present study was to investigate the effect of excipients on the solubility of cranberry anthocyanins and their dissolution kinetics as well as on the disintegration time of the capsules. Selected excipients (sodium carboxymethyl cellulose, beta-cyclodextrin and chitosan) were found to affect the solubility and release kinetics of anthocyanins in freeze-dried cranberry powder. Capsule formulations N1–N9 had a disintegration time of less than 10 min, and capsule formulation N10 containing 0.200 g of freeze-dried cranberry powder, 0.100 g of Prosolv (combination of microcrystalline cellulose and colloidal silicon dioxide), and 0.100 g of chitosan had a capsule disintegration time of over 30 min. The total amount of anthocyanins released into the acceptor medium ranged from 1.26 ± 0.06 mg to 1.56 ± 0.03 mg. Capsule dissolution test data showed that the time to release into the acceptor medium was statistically significantly longer for the chitosan-containing capsule formulations compared to the control capsules (p < 0.05). Freeze-dried cranberry fruit powder is a potential source of anthocyanin-rich dietary supplements, and the choice of excipient chitosan could be a suitable solution in capsule formulations providing greater anthocyanin stability and modified release in the gastrointestinal tract.

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“…The main properties of composites are closely related to the dispersion of the filler particles in the polymer and the wettability of the filler and polymer. [ 27 ] The surface of cellulose is rich in polar hydroxyl groups and thus has poor interface compatibility with non‐polar polymer. Consequently, cellulose is difficult to disperse in the non‐polar polymer because it can easily aggregate.…”

Section: Introductionmentioning

confidence: 99%

Development and molecular dynamics simulation of green natural rubber composites with modified sisal microcrystalline cellulose

Chen

Huang

Wang

et al. 2022

Vinyl Additive Technology

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In this study, green composites were prepared using natural rubber (NR) as the matrix and the sisal microcrystalline cellulose (MCC) as the filler. Three modifying agents oleic acid (OA), γ-aminopropyltriethoxylsilane (KH550), and bis-γ-(triethoxysilylpropyl)-tetrasulfide (Si69) were individually tested to modify the MCC to improve the interfacial compatibility of the NR and MCC. Combined with modern instrumental analysis technology and molecular dynamics simulation, the reinforcing effect and microscopic mechanism of modified MCC on NR were analyzed. The structure-activity relationship of NR and MCC composites was further revealed, and the interaction between the two components was clarified. At the same time, the reinforcing and compatibilizing effect of three kinds of modified MCC in NR matrix were also revealed. The results showed that the properties of NR/Mod-MCC composites were better than those of NR/MCC composites, where NR/OA-MCC presented the highest tensile strength, followed by NR/Si69-MCC. In addition, NR/Si69-MCC exhibited higher elongation at break and NR/KH550-MCC exhibited higher vulcanization characteristics. Molecular model systems were constructed through molecular dynamics simulation to investigate the interactions between the three modified cellulose molecules and the NR molecules.OA-cellulose has a better interaction with NR than KH550-cellulose and Si69-cellulose, The simulation results were consistent with the experimental results.

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Methods for Cellulose Modification in the Development of Polymeric Composite Materials (Review)

Cited by 21 publications

References 33 publications

Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Formulation and Biopharmaceutical Evaluation of Capsules Containing Freeze-Dried Cranberry Fruit Powder

Development and molecular dynamics simulation of green natural rubber composites with modified sisal microcrystalline cellulose

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