Methods for assessing cardiac myofilament calcium sensitivity
Jarrah M. Dowrick,
Andrew J. Taberner,
June-Chiew Han
et al.
Abstract:Myofilament calcium (Ca2+) sensitivity is one of several mechanisms by which force production of cardiac muscle is modulated to meet the ever-changing demands placed on the heart. Compromised Ca2+ sensitivity is associated with pathologies, which makes it a parameter of interest for researchers. Ca2+ Sensitivity is the ratio of the association and dissociation rates between troponin C (TnC) and Ca2+. As it is not currently possible to measure these rates in tissue preparations directly, methods have been devel… Show more
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