Methods and potential biomarkers for the evaluation of endothelial dysfunction in chronic kidney disease: A critical approach

Hogaş, Simona; Voroneanu, Luminița; Şerban, Dragomir Nicolae; Segall, Liviu; Hogaș, Mihai; Șerban, Ionela Lăcrămioara; Covic, Adrian

doi:10.1016/j.jash.2010.03.008

Cited by 38 publications

(38 citation statements)

References 114 publications

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“…These findings are in agreement with other published results (11,18,36). Interestingly, normotensive patients with ADPKD and preserved renal function had a heightened vascular inflammatory state as evidenced by higher levels of ICAM, P-selectin, E-selectin, and sFas compared with healthy controls (16).…”

supporting

confidence: 93%

Endothelial dysfunction and oxidative stress in polycystic kidney disease

Klawitter

Reed-Gitomer

McFann

et al. 2014

American Journal of Physiology-Renal Physiology

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cular disease (CVD) is the leading cause of premature mortality in ADPKD patients. The aim was to identify potential serum biomarkers associated with the severity of ADPKD. Serum samples from a homogenous group of 61 HALT study A ADPKD patients [early disease group with estimated glomerular filtration rate (eGFR) Ͼ60 ml·min Ϫ1 ·1.73 m Ϫ2 ] were compared with samples from 49 patients from the HALT study B group with moderately advanced disease (eGFR 25-60 ml·min Ϫ1 ·1.73 m Ϫ2 ). Targeted tandem-mass spectrometry analysis of markers of endothelial dysfunction and oxidative stress was performed and correlated with eGFR and total kidney volume normalized to the body surface area (TKV/BSA). ADPKD patients with eGFR Ͼ60 ml·min Ϫ1 ·1.73 m Ϫ2 showed higher levels of CVD risk markers asymmetric and symmetric dimethylarginine (ADMA and SDMA), homocysteine, and S-adenosylhomocysteine (SAH) compared with the healthy controls. Upon adjustments for age, sex, systolic blood pressure, and creatinine, SDMA, homocysteine, and SAH remained negatively correlated with eGFR. Resulting cellular methylation power [S-adenosylmethionine (SAM)/SAH ratio] correlated with the reduction of renal function and increase in TKV. Concentrations of prostaglandins (PGs), including oxidative stress marker 8-isoprostane, as well as PGF2␣, PGD2, and PGE2, were markedly elevated in patients with ADPKD compared with healthy controls. Upon adjustments for age, sex, systolic blood pressure, and creatinine, increased PGD2 and PGF2␣ were associated with reduced eGFR, whereas 8-isoprostane and again PGF 2␣ were associated with an increase in TKV/BSA. Endothelial dysfunction and oxidative stress are evident early in ADPKD patients, even in those with preserved kidney function. The identified pathways may provide potential therapeutic targets for slowing down the disease progression.

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supporting

confidence: 93%

Endothelial dysfunction and oxidative stress in polycystic kidney disease

Klawitter

Reed-Gitomer

McFann

et al. 2014

American Journal of Physiology-Renal Physiology

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“…The causes of inflammation are multiple, including decreased renal function, chronic volume overload, comorbidities, factors associated with the dialysis procedure, and genetic factors. C-reactive protein (CRP) was initially suggested to be merely a biomarker of inflammation, but recent data show that circulating CRP is also a mediator of atherogenesis and inflammation [12][13][14] . An inverse relationship between CRP and endothelium-dependent vasoreactivity has been described, which suggests that CRP can be a link between inflammation and ED [15] .…”

Section: Evidence Of Endothelial Dysfunction In Chronic Kidney Diseasementioning

confidence: 99%

“…Light undergoes changes in wavelength (Doppler shift) when it is reflected by the moving red blood cells in the microvasculature and a photodiode measures the emerged beam. The magnitude and frequency distribution of these changes in wavelength are related to the number and velocity of moving red blood cells [14,26,27] . Several different signals can be recorded but the red blood cell flux is used the most.…”

Section: Study Of Endothelial Dysfunctionmentioning

confidence: 99%

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Evaluation of microvascular reactivity with laser Doppler flowmetry in chronic kidney disease

Babos

Járai²,

Nemcsik³

2013

WJN

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Cardiovascular diseases are the major causes of mortality in patients with chronic kidney disease (CKD). The complex process of accelerated athero-and arteriosclerosis in CKD is associated with this phenomenon, where endothelial dysfunction (ED) is one of the initial steps. Hence, the early diagnosis of ED can potentially lead to early interventions which could result in a better outcome for these patients. Several methodologies have been developed for the diagnosis of ED. Laser Doppler flowmetry (LDF) enables us to study the microcirculation continuously in a non-invasive manner. In our review we would like to focus on different tests developed for LDF, like postocclusive reactive hyperaemia, local heating, iontophoresis, microdialysis or analysis of flowmotion. We would also like to summarize the available data in CKD with these methodologies to enlighten their perspectives in the clinical use on this patient population.

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“…1 Furthermore, minimally invasive skinspecific methodologies using laser systems make the cutaneous circulation a useful translational model for investigating mechanisms of skin physiology and skin pathophysiology induced either by skin disease itself or by other diseases such as vascular, rheumatologic, and pneumologic. To date, the skin has been used as a circulation model to investigate vascular mechanisms in a variety of diseased states, including hypercholesterolemia, 8 Alzheimer disease, 9 carpal tunnel syndrome, 10 schizophrenia, 11 hypertension, 6 renal disease, 12 type 2 diabetes, 13 peripheral vascular disease, 14 atherosclerotic coronary artery disease, 2 heart failure, 15 systemic sclerosis, 16 obesity, 17 primary aging, 18,19 and sleep apnea. 20 Assessment of skin microvascular function can be done by both invasive and noninvasive techniques.…”

mentioning

confidence: 99%