Methods and instruments of high-resolution transient THz spectroscopy for diagnostics of socially important diseases

Вакс, В. Л.; Домрачева, Е. Г.; Приползин, С. И.; Sobakinskaya, E. A.; Chernyaeva, M. B.; Anfertev, Vladimir; Семенова, А. В.; Shatrova, Yu. S.

doi:10.3103/s1541308x14030030

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…BWO provides a rather high radiation power, up to several tens of milliwatts. A combination of several BWOs allows high-resolution spectroscopy [190,191] and imaging [109,192] to be performed in the wide frequency range of 30GHz to 1.5THz. Such devices need a magnetic field to focus the electron beam and power-supply unit.…”

Section: Instruments Of Terahertz Spectroscopy and Imaging For Tissue...mentioning

confidence: 99%

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

Zaytsev

Dolganova

Chernomyrdin

et al. 2019

J. Opt.

163

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Over the past few decades, significant attention has been paid to the biomedical applications of terahertz (THz) technology. Nowadays, THz spectroscopy and imaging have allowed numerous demanding problems in the biological, medical, food, plant and pharmaceutical sciences to be solved. Among the biomedical applications, the label-free diagnosis of malignant and benign neoplasms represents one of the most attractive branches of THz technology. Despite this attractiveness, THz diagnosis methods are still far from being ready for use in medical practice. In this review, we consider modern research results in the THz diagnosis of malignant and benign neoplasms, along with the topical research and engineering problems which restrain the translation of THz technology to clinics. We start by analyzing the common models of THz-wave-tissue interactions and the effects of tissue exposure to THz waves. Then, we discuss the existing modalities of THz spectroscopic and imaging systems, which have either already been applied in medical imaging, or hold strong potential. We summarize the earlier-reported and original results of the THz measurements of neoplasms with different nosology and localization. We pay attention to the origin of contrast between healthy and pathological tissues in the THz spectra and images, and discuss the prospects of THz technology in

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Section: Instruments Of Terahertz Spectroscopy and Imaging For Tissue...mentioning

confidence: 99%

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

Zaytsev

Dolganova

Chernomyrdin

et al. 2019

J. Opt.

163

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“…The non-stationary signals arising due to these processes are recorded and accumulated in the receiving unit of the spectrometer. Their magnitude and shape can be used to determine, with a high degree of accuracy, the concentration of the gas mixture components under study [17].…”

Section: Two-frequency Thz Spectroscopymentioning

confidence: 99%

Two-Frequency THz Spectroscopy for Analytical and Dynamical Research

Yablokov

Anfertev

Revin

et al. 2015

IEEE Trans. THz Sci. Technol.

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Development of high-sensitivity and high resolution analytical spectroscopy is an area of active research interest currently. In the paper a method of two-frequency THz spectroscopy is presented. A laboratory model of spectrometer using two independent radiation sources of 118-178 GHz and 330-390 GHz ranges and a single detector with 500-2500 V/W sensitivity is presented. Test measurements allowed detecting two gases simultaneously with the minimal registration period of 4 s and the hardware resolution of 1 kHz. These experiments proved this new trend in analytical spectroscopy to have wide application prospects for a variety of fundamental and applied scientific problems. In the first place, it is laboratory modeling of the processes of atmospheric and space chemistry, studying of their dynamics as well as transformations and changes of mixture composition. Besides, the proposed method can be applied to investigations of fast processes, detection of intermediate and short-lived products of chemical reactions.Index Terms-High resolution transient spectroscopy, phase switching, terahertz (THz) frequency range, two-frequency spectrometer.

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